Dopamine's Role in Impulse Control and Reward Learning in Humans
多巴胺在人类冲动控制和奖励学习中的作用
基本信息
- 批准号:10365933
- 负责人:
- 金额:$ 5.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-01 至 2025-11-30
- 项目状态:未结题
- 来源:
- 关键词:AffectAlcohol dependenceAreaBehaviorBehavioralBehavioral SciencesBrain regionCharacteristicsChoice BehaviorClinicalClinical assessmentsComputersConsciousCorpus striatum structureDSM-VDataData AnalysesData CollectionDecision MakingDeep Brain StimulationDetectionDiabetes MellitusDiseaseDoctor of PhilosophyDopamineDopamine AgonistsElectrochemistryElectrodesEventExhibitsFeedbackFutureGamblingHumanImpulse Control DisordersImpulsivityIndividualLearningMajor Depressive DisorderManuscriptsMeasurementMeasuresMedicalMental disordersMentorshipMethodsNational Institute of Mental HealthNeurosciencesOperative Surgical ProceduresOutcomeParkinson DiseaseParticipantPatient RecruitmentsPatientsPharmaceutical PreparationsPlayPopulationPreparationProcessPsychological reinforcementPunishmentQuestionnairesRecording of previous eventsResearchResearch Domain CriteriaRewardsRiskRisk BehaviorsRisk-TakingRoleScientistSignal TransductionSpecificityStimulusSubstance Use DisorderSymptomsSyndromeSystemTechnologyTestingTimeTrainingWorld Health Organizationaddictionbasebehavior influencebehavior measurementdesigndopamine systemdopaminergic neuronexperienceexperimental studyforesthigh riskimplantationmedical schoolsmultidisciplinaryneurochemistryneuroimagingneurosurgerynew therapeutic targetnovelnovel strategiesprogramsprospectiveresponsereward processingtrait
项目摘要
Project Summary
The DSM-V categorized gambling disorder as the first behavioral addiction. The World Health Organization
(WHO) identified problem gambling as a necessary area for further research, with a burden of harm surpassing
substance use disorder and diabetes. Impulsivity is an important trait found on clinical assessment of gambling
disorder, and gambling disorder can be induced by dopamine replacement medications in a clinical syndrome
termed impulse control disorder (ICD). Dopamine agonist therapy is more responsible than other dopamine
replacement options, with patients on dopamine agonists experiencing roughly three times greater odds of
developing ICD. Neuroimaging studies have pinpointed the striatum as a culprit brain region for dopamine
abnormalities, with recent technologic advances in human electrochemistry providing the temporal specificity
necessary to correlate sub-second dopamine fluctuations to differences in reward learning. The NIMH RDoC
construct ‘Reward Learning’ and its subconstructs, ‘Reward Prediction Error’ and ‘Probabilistic and
Reinforcement Learning’ provide a framework to investigate temporal differences in dopamine fluctuations
corresponding to differences in decision-making in ICD. Based on preliminary data showing dopaminergic
signaling is altered in ICD corresponding to impulsivity, this proposal will investigate the following specific aims:
(1) Quantify patients’ threshold for risk-taking and the behavioral influence of RPEs in patients with a history of
ICD both on and off dopaminergic medications. (2) Measure sub-second dopamine fluctuations in the striatum
during decision-making under risk. Methods will employ human reward learning tasks and simultaneous human
electrochemistry. Training will take place at the Wake Forest School of Medicine in the Neuroscience and the
Medical programs as a part of the MD/PhD program. The applicant will receive training in the human
electrochemistry and behavioral science methods necessary to accomplish the proposed aims. The applicant
also places an emphasis on analytical training in R programming. Mentorship includes a multidisciplinary team
with individuals in the neurosurgery and neuroscience departments. This team will provide the applicant with
feedback regarding project implementation, data collection and analysis, and manuscript preparation. The
proposed aims have the potential to provide new therapeutic targets for the treatment of mental health
disorders that involve reward learning.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brittany Liebenow其他文献
Brittany Liebenow的其他文献
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{{ truncateString('Brittany Liebenow', 18)}}的其他基金
Dopamine's Role in Impulse Control and Reward Learning in Humans
多巴胺在人类冲动控制和奖励学习中的作用
- 批准号:
10554431 - 财政年份:2021
- 资助金额:
$ 5.18万 - 项目类别:
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