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Dopamine's Role in Impulse Control and Reward Learning in Humans

多巴胺在人类冲动控制和奖励学习中的作用

基本信息

批准号：
10365933
负责人：
Brittany Liebenow
金额：
$ 5.18万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10365933
关键词：
Affect Alcohol dependence Area Behavior Behavioral Behavioral Sciences Brain region Characteristics Choice Behavior Clinical Clinical assessments Computers Conscious Corpus striatum structure DSM-V Data Data Analyses Data Collection Decision Making Deep Brain Stimulation Detection Diabetes Mellitus Disease Doctor of Philosophy Dopamine Dopamine Agonists Electrochemistry Electrodes Event Exhibits Feedback Future Gambling Human Impulse Control Disorders Impulsivity Individual Learning Major Depressive Disorder Manuscripts Measurement Measures Medical Mental disorders Mentorship Methods National Institute of Mental Health Neurosciences Operative Surgical Procedures Outcome Parkinson Disease Participant Patient Recruitments Patients Pharmaceutical Preparations Play Population Preparation Process Psychological reinforcement Punishment Questionnaires Recording of previous events Research Research Domain Criteria Rewards Risk Risk Behaviors Risk-Taking Role Scientist Signal Transduction Specificity Stimulus Substance Use Disorder Symptoms Syndrome System Technology Testing Time Training World Health Organization addiction base behavior influence behavior measurement design dopamine system dopaminergic neuron experience experimental study forest high risk implantation medical schools multidisciplinary neurochemistry neuroimaging neurosurgery new therapeutic target novel novel strategies programs prospective response reward processing trait

项目摘要

Project Summary The DSM-V categorized gambling disorder as the first behavioral addiction. The World Health Organization (WHO) identified problem gambling as a necessary area for further research, with a burden of harm surpassing substance use disorder and diabetes. Impulsivity is an important trait found on clinical assessment of gambling disorder, and gambling disorder can be induced by dopamine replacement medications in a clinical syndrome termed impulse control disorder (ICD). Dopamine agonist therapy is more responsible than other dopamine replacement options, with patients on dopamine agonists experiencing roughly three times greater odds of developing ICD. Neuroimaging studies have pinpointed the striatum as a culprit brain region for dopamine abnormalities, with recent technologic advances in human electrochemistry providing the temporal specificity necessary to correlate sub-second dopamine fluctuations to differences in reward learning. The NIMH RDoC construct ‘Reward Learning’ and its subconstructs, ‘Reward Prediction Error’ and ‘Probabilistic and Reinforcement Learning’ provide a framework to investigate temporal differences in dopamine fluctuations corresponding to differences in decision-making in ICD. Based on preliminary data showing dopaminergic signaling is altered in ICD corresponding to impulsivity, this proposal will investigate the following specific aims: (1) Quantify patients’ threshold for risk-taking and the behavioral influence of RPEs in patients with a history of ICD both on and off dopaminergic medications. (2) Measure sub-second dopamine fluctuations in the striatum during decision-making under risk. Methods will employ human reward learning tasks and simultaneous human electrochemistry. Training will take place at the Wake Forest School of Medicine in the Neuroscience and the Medical programs as a part of the MD/PhD program. The applicant will receive training in the human electrochemistry and behavioral science methods necessary to accomplish the proposed aims. The applicant also places an emphasis on analytical training in R programming. Mentorship includes a multidisciplinary team with individuals in the neurosurgery and neuroscience departments. This team will provide the applicant with feedback regarding project implementation, data collection and analysis, and manuscript preparation. The proposed aims have the potential to provide new therapeutic targets for the treatment of mental health disorders that involve reward learning.

项目总结