Every Day Counts: A lifestyle program for women metastatic breast cancer
每一天都很重要:针对女性转移性乳腺癌的生活方式计划
基本信息
- 批准号:10366559
- 负责人:
- 金额:$ 68.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAdipose tissueAdoptedAdverse eventAfrican AmericanAmerican Cancer SocietyBehaviorBehavioralBiologicalBiological MarkersBody CompositionCancer SurvivorCaringChronic DiseaseClinicalCommunitiesConsensusControl GroupsDiseaseDisease ManagementDistressEatingEvidence based interventionExerciseExhibitsFatigueFeedbackGoalsGuidelinesHabitsIncidenceInflammationInflammatoryInsulin ResistanceInterventionIntervention TrialLeadLife StyleMediatingMenopausal StatusMetastatic breast cancerMethodologyMicroRNAsMitochondriaMolecularObesityOutcomeParticipantPathway interactionsPatient Outcomes AssessmentsPhysical FunctionPhysical activityPilot ProjectsPrognosisProgram SustainabilityQuality of lifeRandomizedRecommendationResearchSafetySerumSurvivorsSymptomsTestingThinnessToxicity due to chemotherapyTreatment-related toxicityUnderserved PopulationUpdateWaiting ListsWomanWorkadipokinesattentional controlbaseclinically significantcontrol trialdifferential expressionefficacy evaluationexercise interventionexperiencehealthy lifestyleimprovedinnovationinsulin sensitivityinterestintervention effectlifestyle interventionmultidisciplinarynovelnutritionphysiologic modelpilot trialpost interventionprognosis biomarkerprognosticprognostic of survivalprogramsrecruitreduce symptomssurvivorshipsymptom managementtargeted treatmenttherapy designtreatment responsetrendtumor progressionyoung woman
项目摘要
The community of women with metastatic breast cancer (MBC) is growing due to greater disease incidence
and treatment advances, with over 30% of women now surviving over 5 years (vs. just 4% in 2000). Managing
symptoms to maintain the highest quality of life (QOL) is the major goal of care in the metastatic setting. Thus,
research that addresses QOL, prognosis and survivorship in this burgeoning and underserved survivor group
is critically needed. BC treatment is associated with adverse body composition changes, specifically gains in
adipose tissue and reductions in strength and lean mass (LM). Excess adiposity contributes to inflammation
and insulin-resistance, which are theorized to promote tumor progression and loss of LM. Low levels of LM are
associated with chemotherapy toxicity, increased symptom burden and compromised survival in women with
MBC. Lifestyle interventions with early stage BC survivors result in reduced symptoms, improved biomarkers of
BC prognosis and enhanced quality of life (QOL). To date, women with MBC have been largely excluded from
these trials. Our pilot work in women with MBC demonstrates they are interested, capable, adherent and
benefit from participation in a lifestyle intervention. Our results show clinically meaningful improvements in
QOL, increased physical activity and strength. We also find improved trends in biomarkers of prognosis, as
well as mitochondrial function for women in the immediate intervention vs. control group. Further, our work
shows that inflammation-associated microRNAs are differentially expressed following participation in our pilot
trial, providing highly novel potential targets to explain mechanisms by which lifestyle interventions improve
QOL for these women. We propose a randomized atttention control trial in women with MBC (n=176) to test
the immediate and sustained effects of “Every Day Counts,” a 16-week lifestyle intervention based on current
lifestyle recommendations for cancer survivors. This trial is adequately powered to examine changes in: 1)
QOL - the primary determinant of care in the metastatic setting and (2) body composition, serum biomarkers of
prognosis/survival, and pertinent patient reported outcomes. We will also explore mitochondrial function and
novel microRNA signatures associated with inflammatory biomarkers and mitochondrial function. Every Day
Counts incorporates critical feedback and experiences from our pilot study with women with MBC. Our robust,
multidisciplinary study team applies an innovative, highly integrated physiologic model to examine the
mechanistic effects of the intervention on decidedly relevant outcomes of interest. The present study
challenges current clinical assumptions regarding the presumed ineffectiveness of lifestyle behaviors in the
metastatic setting, providing evidence that may inform a paradigm shift expanding the application and
relevance of the nutrition and physical activity guidelines to women with MBC. Importantly, this study will
provide clinicians with updated evidence and strategies to help make every day count for women with MBC
representing high impact for a currently underserved group of survivors.
转移性乳腺癌(MBC)的妇女群体由于疾病发病率的增加而不断增长
项目成果
期刊论文数量(0)
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Patricia Maureen Sheean其他文献
Patricia Maureen Sheean的其他文献
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{{ truncateString('Patricia Maureen Sheean', 18)}}的其他基金
Every Day Counts: A lifestyle program for women metastatic breast cancer
每一天都很重要:针对女性转移性乳腺癌的生活方式计划
- 批准号:
10554411 - 财政年份:2022
- 资助金额:
$ 68.21万 - 项目类别:
Every Day Counts: A Lifestyle Program for Women with Metastatic Breast Cancer
每一天都很重要:针对转移性乳腺癌女性的生活方式计划
- 批准号:
9371470 - 财政年份:2017
- 资助金额:
$ 68.21万 - 项目类别:
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