Cadherin Clusters and actin filaments
钙粘蛋白簇和肌动蛋白丝
基本信息
- 批准号:10366391
- 负责人:
- 金额:$ 46.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-01 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:ActinsAdaptor Signaling ProteinAdherens JunctionAdhesionsAdhesivesAmazeBindingBinding ProteinsCadherinsCell PolarityCell-Cell AdhesionCellsComplexCoupledCytoskeletonDataDevelopmentEventF-ActinFoundationsGenerationsIndividualLateralLightLinkLiquid substanceMediatingMedicineMicrofilamentsMolecularMorphogenesisPharmacologyPlayProcessProteinsRadialReactionRegulationRoleSignal PathwaySignal TransductionSignaling ProteinStratificationStructureTestingTimeTissuesVertebratesWorkalpha cateninbasecell motilitydesignexperimental studyextracellularflexibilityin vitro Modelin vivointercalationmutantnanoclusternovelpractical applicationrecruitscaffoldsolid state
项目摘要
Cadherin clustering is a unique molecular process that mediates and controls cell-cell adhesion. In
addition, it also regulates the actin cytoskeleton, polarity, proliferation, and apparently other structures
and signaling pathways. Cadherin clusters reinforce weak individual adhesive bonds and generate
functional cell-cell adhesion links. By connecting to F-actin, they determine the overall organization
and dynamics of the actin cytoskeleton. Finally, they provide specific structural scaffolds for various
signaling pathways. Despite such incredibly important functions, which obviously play out in nearly
every aspect of tissue morphogenesis, the molecular mechanisms and regulation of cadherin
clustering remains to be studied. This proposal will shed light on how cadherin clusters form and how
they participate in such diverse array of cellular mechanisms.
The work done under this proposal in previous years showed that adherens junctions (AJs), the major
cell-cell adhesion structures in vertebrates, consist of numerous transient but highly adhesive
cadherin nanoclusters. The short lifetime of each cluster makes AJs adhesive and flexible at the same
time. The continuous generation of these clusters is apparently based on a remarkable reaction –
cooperative binding of the cadherin-associated protein α-catenin to actin filaments. The assembly-
disassembly cycles of both cadherin clusters and associated F-actin are tightly coupled thereby
synchronizing cadherin and actin dynamics in adjacent cells. Finally, we found that cadherin clusters
could be structurally diversified by cadherin/catenin-bound proteins. Diversification of cadherin
clustering is based on the fact that each of these proteins provides specific modes of lateral cadherin-
cadherin interactions. A variety of these interactions results in formation of an array of distinct clusters
each of which might have particular functions. The advances in understanding cadherin clustering
allow us to come up with this proposal, which includes: (i) the role of cadherin in clustering and
function of two proteins, signaling protein Erbin, and adaptor protein PLEKHA5; (ii) molecular
mechanisms interconnecting extracellular cadherin binding events with α-catenin-binding to F-actin;
and (iii) the role of cadherin clustering in some examples of tissue morphogenesis.
钙粘蛋白聚集是一个独特的分子过程,介导和控制细胞-细胞粘附。在
项目成果
期刊论文数量(0)
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专利数量(0)
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Sergey M Troyanovsky其他文献
Sergey M Troyanovsky的其他文献
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{{ truncateString('Sergey M Troyanovsky', 18)}}的其他基金
Functional and Structural Links between Cadherin, Gamma-Secretase, and Notch
钙粘蛋白、γ-分泌酶和 Notch 之间的功能和结构联系
- 批准号:
8654254 - 财政年份:2010
- 资助金额:
$ 46.23万 - 项目类别:
Functional and Structural Links between Cadherin, Gamma-Secretase, and Notch
钙粘蛋白、γ-分泌酶和 Notch 之间的功能和结构联系
- 批准号:
8271257 - 财政年份:2010
- 资助金额:
$ 46.23万 - 项目类别:
Functional and Structural Links between Cadherin, Gamma-Secretase, and Notch
钙粘蛋白、γ-分泌酶和 Notch 之间的功能和结构联系
- 批准号:
8469391 - 财政年份:2010
- 资助金额:
$ 46.23万 - 项目类别:
Functional and Structural Links between Cadherin, Gamma-Secretase, and Notch
钙粘蛋白、γ-分泌酶和 Notch 之间的功能和结构联系
- 批准号:
8111101 - 财政年份:2010
- 资助金额:
$ 46.23万 - 项目类别:
Functional and Structural Links between Cadherin, Gamma-Secretase, and Notch
钙粘蛋白、γ-分泌酶和 Notch 之间的功能和结构联系
- 批准号:
7987304 - 财政年份:2010
- 资助金额:
$ 46.23万 - 项目类别:














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