CHASM: Children Hospitalizations After SARS-COV-2 for MIS-C

CHASM：SARS-COV-2 后儿童因 MIS-C 住院

• 批准号: 10373711
• 负责人: Katherine Ann Scott Auger
• 金额: $ 10万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2022-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373711
• 关键词: CHASM; Children; Hospitalizations; After; SARS

PROJECT SUMMARY Overview of Project: Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious condition affecting children after COVID-19 infection. MIS-C commonly results in severe critical illness and even death. We will provide an examination of MIS-C in 49 children’s hospitals throughout the United States. In this proposal, we will advance knowledge on MIS-C severity of illness as well as evaluate initial treatment regimens. We will describe differences in initial treatment decisions and their associated risk of treatment failure. The completion of this work will result in new knowledge regarding the most effective initial treatments for MIS-C. Environment: Cincinnati Children’s Hospital Medical Center (CCHMC) is the second largest pediatric recipient of funding from the NIH. Drs. Auger and Brady are members of the Division of Hospital Medicine at CCHMC. This division is among the most research-oriented pediatric hospital medicine divisions in the country with a focus on hospital quality and safety and with four faculty members currently on AHRQ grants. Both PIs receive extensive support including computers and software, biostatistical advisors, data management support, clinical research coordinators, grants management support, and discretionary funds. Drs. Auger and Brady are also a members of CCHMC’s James M. Anderson Center for Health Systems Excellence, a nationally renowned research division that focuses on assessing and improving pediatric health care delivery. This proposal additionally leverages the vast resources of the Children’s Hospital Association (CHA) and its experienced biostatistical and data analysis team. Dr. Matt Hall as the principal biostatistician at CHA has a decade-plus experience using the Pediatric Health Information System (PHIS) to ask and answer epidemiologic and comparative effectiveness research questions. He has an extensive record of collaboration with the entire research team, having coauthored over 100 publications with members of this team. Summary: This innovative proposal will generate new, significant knowledge on both the epidemiology and management of MIS-C. This critically important information is foundational for future randomized controlled trials for MIS-C treatment and for development of evidence-based treatment algorithms and pathways.

项目总结 项目概述：儿童多系统炎症综合征(MIS-C)是一个严重的 新冠肺炎感染后影响儿童的情况。MIS-C通常会导致严重的危重 疾病甚至死亡。我们将在49家儿童医院提供管理信息系统C的检查 在整个美国。在这项建议中，我们将提高对管理信息系统-C严重性的了解 以及评估最初的治疗方案。我们将描述首字母中的差异 治疗决定及其相关的治疗失败风险。这项工作的完成 将使人们对最有效的早期治疗方法有了新的认识。 环境：辛辛那提儿童医院医疗中心(CCHMC)是第二大 接受美国国立卫生研究院资助的儿科。奥格尔博士和布雷迪博士是 CCHMC的医院医学。这个部门是最注重研究的儿科之一。 全国医院医学部，重点是医院质量和安全，并 目前有四名教职员工领取AHRQ补助金。这两家私人投资机构都得到了广泛的支持，包括 计算机和软件、生物统计顾问、数据管理支持、临床研究 协调人、赠款管理支助和可自由支配资金。奥格尔博士和布雷迪博士 也是CCHMC的詹姆斯·M·安德森健康系统卓越中心的成员 全国知名的研究部门，专注于评估和改善儿科健康 护理服务。这项建议还利用了儿童医院的大量资源 协会(CHA)及其经验丰富的生物统计和数据分析团队。马特·霍尔博士饰演 CHA首席生物统计师有十多年使用儿科健康中心的经验 问答流行病学和比较有效性的信息系统(PHIS) 研究问题。他与整个研究团队有着广泛的合作记录， 与这个团队的成员合著了100多本出版物。 摘要：这项创新的提案将在以下两方面产生新的重要知识 管理信息系统感染的流行病学和管理。这一至关重要的信息是 未来管理信息系统-C治疗和循证发展的随机对照试验 治疗算法和途径。