Neural mechanisms of error correction during manual interception of moving targets

手动拦截移动目标过程中纠错的神经机制

• 批准号: 10373510
• 负责人: Robert A. Scheidt
• 金额: $ 42.08万
• 依托单位: MARQUETTE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10373510
• 关键词: Address; Ballistics; Basic Science; Behavior; Behavioral; Brain; Child; Cognition; Coupled; Cues; Data; Detection; Electroencephalography; Engineering; Environment; Error Sources; Event; Financial compensation; Foundations; Future; Generations; Goals; Hand; Human; Impairment; Injury; Intercept; Intervention; Kinetics; Knowledge; Life; Limb structure; Location; Manuals; Measurement; Mission; Motion; Motor; Movement; Muscle; National Institute of Neurological Disorders and Stroke; Neurologic; Neurons; Neurosciences; Patients; Performance; Positioning Attribute; Process; Production; Property; Quality of life; Response Latencies; Robot; Robotics; Running; Sensory; Shapes; Source; Speed; Stroke; System; Techniques; Testing; Therapeutic Intervention; Time; Uncertainty; Update; Variant; Visual; Work; arm; base; cognitive function; experimental study; flexibility; grasp; human subject; information processing; innovation; kinematics; multidisciplinary; nerve injury; neural circuit; neural correlate; neural patterning; neuroimaging; neuromechanism; novel; object motion; post stroke; relating to nervous system; response; robot rehabilitation; source localization; spatiotemporal; stroke survivor; success; temporal measurement; therapeutic development; therapeutic evaluation; therapy design

Project Summary Sensorimotor impairment is common after stroke. Sensorimotor impairment can degrade quality of life by limiting simple acts like reaching to catch a child's hand. This project is based on the premise that the individualization of therapeutic intervention needed to optimize motor function after neuromotor injury is predicated on an understanding how healthy brains integrate sensory, motor, and cognitive functioning to control movement. Our project focuses on reaching to moving objects using a cued manual interception task because interception underlies many activities of daily life in an unpredictable environment. People and objects do not always move as expected, making mid-movement error corrections critical for success. Our project will advance a fundamental understanding of how the brain adjusts ongoing actions to correct performance errors that arise mid-movement. We focus on neurologically intact people as a foundational step toward our long-term goal, which is to develop and test intervention strategies to address the impact of each patient's neural injury on spatiotemporal and dynamic aspects of error correction in everyday activities. Cued manual interception affords ideal experimental control over the timing of events giving rise to movement and error. Our innovative project exploits the precision motion and measurement abilities of a rehabilitation robot, the fine temporal resolution of electroencephalography (EEG), and a highly multidisciplinary team to advance understanding of the behavioral and neural basis of mid-movement error correction during manual interception. We will characterize behavioral and neural responses to three different sources of error: inherent errors in the selection and execution of action, unpredictable target motion, and unpredictable environmental dynamics resisting hand motion. Error correction is significant to study because it enables success in everyday tasks, particularly when things do not go as initially planned. We will conduct human subjects experiments that will address two specific aims. Neurologically-intact people will hold the handle of a planar robot while trying to catch a moving visual target. Infrequently, at reach onset target speed will increase or the robot will render an unexpected change to the hand's load. Analysis of behavioral data (Aim 1) will determine the dynamics of behavioral corrections in response to target interception errors. We hypothesize that response latencies reflect differences in information processing required to correct errors arising from the three different error sources. Analysis of EEG data (Aim 2) will identify patterns of neural activity and functional connectivity leading to error corrections in response to target interception errors. We hypothesize that neural correlates of error correction reflect differences in the type and timing of information processing required to compensate for the three sources of error. If successful, this R21 project will lead to new knowledge about the spatiotemporal patterns of neural activity in response to errors that arise when reaching toward moving targets. This project will also identify neural circuits contributing to the initiation of movement, to the on-line detection of performance errors, and to the generation of corrective actions in response to those errors. Advancing understanding of mid-movement error correction will facilitate the development of therapeutic interventions designed to enhance functional movement and quality of life in patients with neuromotor injury.

项目摘要 卒中后感觉运动障碍是常见的。感觉运动障碍可通过限制简单运动而降低生活质量 就像伸手去抓孩子的手一样。这个项目是基于这样一个前提，即治疗的个性化 神经运动损伤后优化运动功能所需的干预是基于对健康程度的了解 大脑整合了感觉、运动和认知功能来控制运动。我们的项目重点是达到 使用提示的手动拦截任务移动对象，因为拦截是日常生活中许多活动的基础 不可预测的环境。人和物体并不总是按预期移动，而是在移动过程中进行误差修正 对成功至关重要。我们的项目将促进对大脑如何调整正在进行的动作以 纠正移动过程中出现的性能错误。我们专注于神经学上完好无损的人作为一个基础步骤 我们的长期目标是开发和测试干预策略，以解决每个患者 日常活动中纠错的时空和动态方面的神经损伤。 提示人工拦截提供了对引起移动和错误的事件的时间进行理想的实验控制。 我们的创新项目利用了康复机器人的精确运动和测量能力，精细的时间 脑电(EEG)的分辨率，以及一个高度多学科的团队，以促进对 人工拦截时中移纠错的行为学和神经学基础。我们将描述 对三种不同错误来源的行为和神经反应：在选择和执行动作时的固有错误， 不可预测的目标运动，以及不可预测的抵制手部运动的环境动态。纠错是 学习很有意义，因为它能让你在日常工作中取得成功，尤其是在事情没有按最初计划进行的时候。 我们将进行人体实验，以解决两个具体目标。神经学完好的人会坚持 试图捕捉移动的视觉目标时平面机器人的手柄。极少数情况下，在达到目标速度时 增加，否则机器人将使手的负载发生意外变化。行为数据分析(目标1)将 确定响应目标拦截错误的行为校正的动态。我们假设这一反应 延迟反映了纠正这三个不同错误所需的信息处理的差异 消息来源。分析脑电数据(目标2)将识别导致错误的神经活动和功能连接的模式 针对目标拦截错误的修正。我们假设纠错的神经关联反映了 补偿三个误差源所需的信息处理的类型和时间上的差异。 如果成功，这个R21项目将带来关于神经活动时空模式的新知识 到达移动目标时出现的错误。该项目还将确定神经回路对 移动的启动、性能错误的在线检测以及在 对这些错误的回应。加深对运动中误差修正的认识，将有助于运动中误差修正的发展 旨在提高神经运动损伤患者功能运动和生活质量的治疗干预措施。