The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)

抗癫痫治疗的癫痫生物信息学研究 (EpiBioS4Rx)

• 批准号: 10368714
• 负责人: JEROME NONE ENGEL
• 金额: $ 3.75万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-08 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10368714
• 关键词: Accounting; Acute; Animal Model; Animals; Antiepileptogenic; Archives; Bioinformatics; Biological; Biological Markers; Blood; Clinical; Clinical Trials; Clinical Trials Network; Cognitive; Data; Development; Diagnosis; Early Post-Traumatic Seizures; Electroencephalography; Electrophysiology (science); Ensure; Epilepsy; Epileptogenesis; Fee-for-Service Plans; Future; Hemoglobin; High Frequency Oscillation; Hippocampus (Brain); Human; Image; Intake; Intervention; Intervention Trial; Magnetic Resonance Imaging; Metabolic; Methods; Modeling; Monitor; Morphology; National Institute of Neurological Disorders and Stroke; Nature; Outcome; Pathologic; Pathology; Pathway interactions; Patient Selection; Patients; Performance; Pharmaceutical Preparations; Plasma; Population; Post-Traumatic Epilepsy; Process; Public Health; Quality Control; Resolution; Resources; Sampling; Scalp structure; Seizures; Serum; Services; Site; Structure; Surface; Therapeutic Intervention; Time; Transportation; Traumatic Brain Injury; base; biobank; biomarker performance; design; efficacy testing; flexibility; high risk; magnetic resonance imaging biomarker; multimodality; novel; patient population; personalized medicine; preclinical trial; prevent; programs; prospective; quality assurance; repository

PROJECT SUMMARY The EpiBioS4Rx program requires long term storage, archival, and distribution of biological samples. These activities have been deemed to be beyond the capacity of our center to perform at a professional level, with necessary quality assurances and fail-safes of sample storage. Thus, we sought a professional resource for this, namely BioSEND. BioSEND is the National Institute of Neurological Disorders and Stroke (NINDS) biomarker repository, which houses biospecimens collected as part of biomarker studies supported by the NINDS. BioSEND will complete all biorepository needs for this study and supply kits, supplemental kits, transportation, plasma receipt and processing, buffy coat intake, extraction and quality control, and hemoglobin quality control. This will be set up as fee for service and we will monitor all services in conjunction with UCLA.

项目摘要 EPIBIOS4RX程序需要长期存储，档案和生物样品分布。这些 活动被认为超出了我们中心在专业层面上执行的能力， 样品存储的必要质量保证和故障保护。因此，我们为此寻求专业资源， 即生物限制。 BioSend是美国国家神经系统疾病与中风研究所（NINDS）生物标志物 存储库，该存储库容纳在Ninds支持的生物标志物研究的一部分中收集的生物测量。 BioSend将满足这项研究和提供工具包，补充工具包，运输， 血浆收据和加工，Buffy Coat摄入量，提取和质量控制以及血红蛋白质量控制。 这将作为服务费用设置，我们将与UCLA一起监视所有服务。

项目成果

A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force.

• DOI: 10.1002/epi4.12260
• 发表时间: 2018-11
• 期刊: Epilepsia open
• 影响因子: 3
• 作者: Ono T;Wagenaar J;Giorgi FS;Fabera P;Hanaya R;Jefferys J;Moyer JT;Harte-Hargrove LC;Galanopoulou AS
• 通讯作者: Galanopoulou AS

Commentary on Li et al. "Disrupted female estrous cyclicity in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy".

对李等人的评论。

• DOI: 10.1002/epi4.12116
• 发表时间: 2018
• 期刊: Epilepsia open
• 影响因子: 3
• 作者: Mazarati,Andrey;Galanopoulou,AristeaS
• 通讯作者: Galanopoulou,AristeaS

Rodent models: Where it all started with these "truths".

啮齿动物模型：一切都始于这些“真相”。

• DOI: 10.1016/j.ejpn.2019.12.011
• 发表时间: 2020
• 期刊: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
• 作者: Molinero,Isaac;Galanopoulou,AristeaS;Moshé,SolomonL
• 通讯作者: Moshé,SolomonL

Readmission after epilepsy monitoring unit discharge in a nationally representative sample.

癫痫监测单位在全国代表性样本中出院后再次入院。

• DOI: 10.1016/j.eplepsyres.2021.106670
• 发表时间: 2021
• 期刊: Epilepsy research
• 影响因子: 2.2
• 作者: Blank,LeahJ;Agarwal,Parul;Jetté,Nathalie
• 通讯作者: Jetté,Nathalie

Why monitor the neonatal brain-that is the important question.

• DOI: 10.1038/s41390-022-02040-9
• 发表时间: 2023-01
• 期刊: PEDIATRIC RESEARCH
• 影响因子: 3.6
• 作者: Vanhatalo, Sampsa;Stevenson, Nathan J.;Pressler, Ronit M.;Abend, Nicholas S.;Auvin, Stephane;Brigo, Francesco;Cilio, M. Roberta;Hahn, Cecil D.;Hartmann, Hans;Hellstrom-Westas, Lena;Inder, Terrie E.;Moshe, Solomon L.;Nunes, Magda L.;Shellhaas, Renee A.;Vinayan, Kollencheri P.;de Vries, Linda S.;Wilmshurst, Jo M.;Yozawitz, Elissa;Boylan, Geraldine B.
• 通讯作者: Boylan, Geraldine B.