The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)

抗癫痫治疗的癫痫生物信息学研究 (EpiBioS4Rx)

• 批准号: 10368714
• 负责人: JEROME NONE ENGEL
• 金额: $ 3.75万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-08 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10368714
• 关键词: Accounting; Acute; Animal Model; Animals; Antiepileptogenic; Archives; Bioinformatics; Biological; Biological Markers; Blood; Clinical; Clinical Trials; Clinical Trials Network; Cognitive; Data; Development; Diagnosis; Early Post-Traumatic Seizures; Electroencephalography; Electrophysiology (science); Ensure; Epilepsy; Epileptogenesis; Fee-for-Service Plans; Future; Hemoglobin; High Frequency Oscillation; Hippocampus (Brain); Human; Image; Intake; Intervention; Intervention Trial; Magnetic Resonance Imaging; Metabolic; Methods; Modeling; Monitor; Morphology; National Institute of Neurological Disorders and Stroke; Nature; Outcome; Pathologic; Pathology; Pathway interactions; Patient Selection; Patients; Performance; Pharmaceutical Preparations; Plasma; Population; Post-Traumatic Epilepsy; Process; Public Health; Quality Control; Resolution; Resources; Sampling; Scalp structure; Seizures; Serum; Services; Site; Structure; Surface; Therapeutic Intervention; Time; Transportation; Traumatic Brain Injury; base; biobank; biomarker performance; design; efficacy testing; flexibility; high risk; magnetic resonance imaging biomarker; multimodality; novel; patient population; personalized medicine; preclinical trial; prevent; programs; prospective; quality assurance; repository

PROJECT SUMMARY The EpiBioS4Rx program requires long term storage, archival, and distribution of biological samples. These activities have been deemed to be beyond the capacity of our center to perform at a professional level, with necessary quality assurances and fail-safes of sample storage. Thus, we sought a professional resource for this, namely BioSEND. BioSEND is the National Institute of Neurological Disorders and Stroke (NINDS) biomarker repository, which houses biospecimens collected as part of biomarker studies supported by the NINDS. BioSEND will complete all biorepository needs for this study and supply kits, supplemental kits, transportation, plasma receipt and processing, buffy coat intake, extraction and quality control, and hemoglobin quality control. This will be set up as fee for service and we will monitor all services in conjunction with UCLA.

项目摘要 EpiBioS4Rx项目需要长期储存、存档和分发生物样本。这些 活动被认为超出了我们中心在专业水平上的能力， 必要的质量保证和样品储存的故障保险。因此，我们寻求专业资源， 即BioSEND。BioSEND是国家神经疾病和中风研究所（NINDS）的生物标志物 储存库，其中存放了作为NINDS支持的生物标志物研究的一部分收集的生物标本。 BioSEND将完成本研究的所有生物储存需求，并提供试剂盒、补充试剂盒、运输， 血浆接收和处理、血沉棕黄层摄取、提取和质量控制以及血红蛋白质量控制。 这将被设置为服务费，我们将与加州大学洛杉矶分校一起监控所有服务。

项目成果

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI.

• DOI: 10.3390/ijms232315208
• 发表时间: 2022-12-02
• 期刊: International journal of molecular sciences
• 影响因子: 5.6

Localizing epileptogenic regions using high-frequency oscillations and machine learning.

• DOI: 10.2217/bmm-2018-0335
• 发表时间: 2019-04
• 期刊: Biomarkers in medicine
• 影响因子: 2.2
• 作者: S. Weiss;Zachary Waldman;F. Raimondo;D. Slezak;Mustafa Donmez;G. Worrell;A. Bragin;J. Engel;R. Staba;M. Sperling

A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force.

• DOI: 10.1002/epi4.12260
• 发表时间: 2018-11
• 期刊: Epilepsia open
• 影响因子: 3
• 作者: Ono T;Wagenaar J;Giorgi FS;Fabera P;Hanaya R;Jefferys J;Moyer JT;Harte-Hargrove LC;Galanopoulou AS
• 通讯作者: Galanopoulou AS

Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop.

• DOI: 10.1002/epi4.12490
• 发表时间: 2021-06
• 期刊: Epilepsia open
• 影响因子: 3
• 作者: Galanopoulou AS;Löscher W;Lubbers L;O'Brien TJ;Staley K;Vezzani A;D'Ambrosio R;White HS;Sontheimer H;Wolf JA;Twyman R;Whittemore V;Wilcox KS;Klein B
• 通讯作者: Klein B

Readmission after epilepsy monitoring unit discharge in a nationally representative sample.

癫痫监测单位在全国代表性样本中出院后再次入院。

• DOI: 10.1016/j.eplepsyres.2021.106670
• 发表时间: 2021
• 期刊: Epilepsy research
• 影响因子: 2.2
• 作者: Blank,LeahJ;Agarwal,Parul;Jetté,Nathalie
• 通讯作者: Jetté,Nathalie