The Intersection between Loss of Control Eating and Obesity: The Role of Restriction and Food Reinforcement

饮食失控与肥胖之间的交集：限制和食物强化的作用

• 批准号: 10372264
• 负责人: Katherine Naime Balantekin
• 金额: $ 5.4万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-23
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10372264
• 关键词: Adolescent; Applications Grants; Area; Award; Basic Behavioral Science; Child; Childhood; Data; Development; Doctor of Philosophy; Eating; Eating Behavior; Eating Disorders; Exposure to; Feeding behaviors; Feeling; Food; Goals; Intervention; Knowledge; Laboratory Finding; Learning; Maintenance; Medical; Mentored Research Scientist Development Award; Mentorship; Metabolic dysfunction; Motivation; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Overweight; Prevention trial; Psychological reinforcement; Public Health; Research; Research Personnel; Risk; Risk Factors; Role; Scientist; Time; Training; Translating; Translational Research; Weight; Work; base; behavioral phenotyping; career; comorbidity; design; experience; longitudinal analysis; loss of control over eating; novel; obesity prevention; obesity risk; overweight child; psychologic

PROJECT SUMMARY/ABSTRACT This proposal is for a Mentored Research Scientist Development Award (K01) for Katherine Balantekin, PhD, RD. Training: My long-term career goal is to be an independent investigator studying ingestive behavior and obesity risk factors in children and adolescents with co-morbid overweight/obesity and disordered eating. The proposed K01 will help achieve this by providing training, experience, and mentorship in the areas of: 1) identification of novel treatment targets for those with comorbid overweight/obesity and disordered eating; 2) applying basic behavioral science principles towards understanding ingestive behavior; 3) translating findings from lab-based studies into interventions; 4) evaluating how behavioral phenotypes influence obesity risk over time. This K01 will provide me with the protected time to receive the necessary training to enhance my expertise in these four areas and will propel me to becoming an independent research scientist focused on the intersection of obesity and disordered eating. Research: Overweight/obesity among children is a major public health problem, and children with overweight/obesity are at increased risk for both medical and psychological co-morbidities. Disordered eating begins in childhood, and often manifests as loss of control (LOC) eating, especially in children with overweight/obesity. Children with LOC eating, or the feeling that one cannot control what or how much one is eating, are at increased risk for obesity. However, less is known about mechanisms that increase this risk. Both parental restriction and the relative reinforcing value (RRV) of food, or the motivation to obtain food, are independently associated with child overweight/obesity, and preliminary work suggests that both may also be related to the development and/or maintenance of LOC. The proposed K01 is designed to explore the relationships among LOC eating, exposure to parental restriction, and RRV of food with respect to obesity risk. Summary: Findings from this study will help identify potential targets for a NIDDK R03 grant application to pilot the efficacy of an obesity prevention trial for children with disordered eating at risk for obesity. This K01 will provide me with the training and expertise in identifying behavioral phenotypes for treatment targets, applying basic behavioral science principles towards understanding ingestive behavior, translational science, and acquiring knowledge about novel statistical approaches to analyzing longitudinal data and ingestive behavior data. At the end of this award, I will be an independent research scientist studying ingestive behavior at the intersection of obesity and disordered eating.

项目摘要/摘要 这项建议是为凯瑟琳·巴兰特金博士颁发的导师研究科学家发展奖(K01)， 研发。培训：我的长期职业目标是成为一名研究进食行为和 超重/肥胖和饮食紊乱并存的儿童和青少年的肥胖危险因素。这个 建议的K01将通过在以下方面提供培训、经验和指导来帮助实现这一目标：1) 确定超重/肥胖和饮食紊乱共病患者的新治疗目标；2) 应用行为科学的基本原理来理解进食行为；3)翻译研究结果 从基于实验室的研究到干预措施；4)评估行为表型如何影响肥胖风险 时间到了。这款K01将为我提供受保护的时间，以接受必要的培训，以提高我的 在这四个领域的专业知识，并将推动我成为一名独立研究科学家，专注于 肥胖和饮食失调的交集。研究：儿童超重/肥胖是一个主要的公众 健康问题，超重/肥胖儿童在医疗和心理方面的风险都会增加 并存疾病。进食障碍始于童年，通常表现为失控(LOC)进食， 特别是在超重/肥胖的儿童中。儿童进食过多，或有无法控制的感觉 一个人吃什么或吃多少，患肥胖症的风险就会增加。然而，人们对这种机制知之甚少。 这就增加了这种风险。父母限制和食物的相对强化值(RRV)，或 获取食物的动机，与儿童超重/肥胖和前期工作独立相关 提示两者也可能与LOC的发展和/或维持有关。建议的K01是 旨在探索进食低碳水化合物、接触父母限制和食物RRV之间的关系 关于肥胖风险。总结：这项研究的发现将有助于确定NIDDK的潜在目标 R03拨款申请试行肥胖预防试验对饮食有问题的儿童的疗效 治疗肥胖症。这款K01将为我提供识别以下行为表型的培训和专业知识 治疗目标，应用基本的行为科学原理来理解摄食行为， 翻译科学，并获得关于分析纵向分析的新统计方法的知识 数据和摄食行为数据。在这个奖项结束时，我将成为一名独立研究科学家，研究 在肥胖和饮食紊乱的交叉点上的喜庆行为。