Infection and Rapid Transmission of SARS-C0V-2 in Ferrets

项目摘要/摘要 2019年新出现的冠状病毒病大规模爆发(新冠肺炎) 在世界范围内迅速传播，导致大流行感染和严重的全球卫生紧急情况。在……里面 为防止严重急性呼吸系统综合症冠状病毒2进一步扩散 CoV-2)，了解病毒感染和传播的体内特征是当务之急。 具体地说，一种重现人感染新冠肺炎临床症状的动物模型 迫切需要破译这种病毒的传播途径和病理生物学 最终允许对药物干预进行测试。凭借我们在开发 动物模型，我们最近建立了SARS-CoV-2感染的雪貂模型，并 高度概括人类感染各方面的传播。这项研究的主要目的是 SARS-CoV-2感染、传播和传播雪貂动物模型的综合表征 疫苗干预的发病机制。

Project Summary/Abstract The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), understanding the in vivo characteristics of viral infection and transmission is of high priority. Specifically, an animal model that recapitulates the COVID-19 clinical symptoms in human infection is urgently needed in order to decipher the transmission routes and pathobiology of this virus and ultimately allow testing of pharmaceutical interventions. With our expertise in the development of animal model, we have recently established a ferret model for SARS-CoV-2 infection and transmission that highly recapitulates aspects of the human infection. The main goal of this study is to comprehensively characterize ferret animal model for SARS-CoV-2 infection, transmission and pathogenesis for vaccine interventions.