Infection and Rapid Transmission of SARS-C0V-2 in Ferrets

雪貂中 SARS-C0V-2 的感染和快速传播

• 批准号: 10369137
• 负责人: Jae U Jung
• 金额: $ 53.3万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10369137
• 关键词: 2 year old; 4 year old; Age; Animal Model; Animals; Anti-Inflammatory Agents; Antiviral Agents; Autophagosome; Characteristics; China; Clinical; Code; Complex; Country; Dangerousness; Disease; Family; Fatality rate; Ferrets; Fever; Genes; Genome; Genus Phlebovirus; Host Defense; Human; Immune; Immune Evasion; Immunosuppression; In Vitro; Inclusion Bodies; Infection; Interferon Type I; Interferons; Interleukin-10; Leukocytes; Lipids; MAP3K8 gene; Mediating; Modeling; Molecular; Morbidity - disease rate; Mus; Nonstructural Protein; Nucleoproteins; Pathogenesis; Pathway interactions; Patients; Phosphotransferases; Play; Production; Protein Kinase; RNA; Recombinants; Risk Factors; Role; Severe Fever with Thrombocytopenia Syndrome Virus; Signal Pathway; Signal Transduction; Source; Symptoms; TBK1 gene; TRIM25 gene; Therapeutic; Thrombocytopenia; Ticks; Time; Treatment Efficacy; Vaccines; Viral; Viral Pathogenesis; Virus; Virus Diseases; World Health Organization; age related; aged; base; clinical Diagnosis; cytokine; in vivo; kinase inhibitor; mortality; mouse model; mutant; neutralizing antibody; novel; pathogen; protein kinase inhibitor; response; reverse genetics; transmission process; young adult

Project Summary/Abstract The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), understanding the in vivo characteristics of viral infection and transmission is of high priority. Specifically, an animal model that recapitulates the COVID-19 clinical symptoms in human infection is urgently needed in order to decipher the transmission routes and pathobiology of this virus and ultimately allow testing of pharmaceutical interventions. With our expertise in the development of animal model, we have recently established a ferret model for SARS-CoV-2 infection and transmission that highly recapitulates aspects of the human infection. The main goal of this study is to comprehensively characterize ferret animal model for SARS-CoV-2 infection, transmission and pathogenesis for vaccine interventions.

项目总结/摘要 2019年新出现的冠状病毒病（COVID-19）大规模爆发， 在世界范围内迅速蔓延，导致大流行感染和严重的全球卫生紧急情况。在 为防止严重急性呼吸系统综合症冠状病毒2型（SARS- CoV-2），了解病毒感染和传播的体内特征是高度优先的。 具体而言，一种重现人类感染COVID-19临床症状的动物模型 为了破译这种病毒的传播途径和病理学， 最终允许测试药物干预。凭借我们的专业知识， 动物模型，我们最近建立了一个雪貂模型的SARS-CoV-2感染， 传播，高度概括了人类感染的各个方面。本研究的主要目的是 全面表征SARS-CoV-2感染、传播和 疫苗干预的发病机制。