Cell free HPV DNA detection in the diagnostic and surgical settings
诊断和手术环境中的无细胞 HPV DNA 检测
基本信息
- 批准号:10373210
- 负责人:
- 金额:$ 16.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:Biological AssayBloodBody FluidsCancer DiagnosticsCancer EtiologyCarcinogensCaringCellsClinicalCollaborationsCollectionDataDecision MakingDetectionDiagnosisDiagnosticDiseaseDropsEnvironmentEvaluationExcisionGoldHead and Neck CancerHourHuman PapillomavirusImmunohistochemistryInfrastructureKineticsLeadLife ExpectancyMalignant NeoplasmsMalignant neoplasm of cervix uteriMeasuresMediatingMessenger RNAMethodsMicroscopicModalityMonitorMorbidity - disease rateNatureOperative Surgical ProceduresOropharyngeal Squamous Cell CarcinomaPatientsPlasmaPostoperative PeriodPrevalenceProspective cohortQuality of lifeRecurrenceResearchResidual TumorsRetrospective cohortRiskRisk FactorsSalivaSensitivity and SpecificitySpecificityTestingTimeUnited StatesViralVirusWorkbarrier to carebasebiobankcancer cellcancer typecohortcostcost effectivediagnostic strategydigitalexperiencefunctional outcomesgenome sequencinghigh riskimprovedinnovationinterestliquid biopsypersonalized medicineprognosticprospectivestandard of caretooltumortumor DNAviral DNAwhole genome
项目摘要
PROJECT SUMMARY
HPV mediated Oropharyngeal Squamous Cell Carcinoma (HPVmOPSCC) is increasing in prevalence, surpassing cervical
cancer as the most common HPV mediated malignancy in the United States. Current treatment approaches for
HPVmOPSCC result in significant long-term morbidity and decreased quality of life. As HPVmOPSCC patients are more
responsive to treatment than “traditional” carcinogen induced OPSCC, and thus experience longer life expectancy after
cure, interest is focused on de-intensifying treatment to improve functional outcomes, including the use of surgery as a
single modality approach. A major barrier to treatment de-intensification is the imprecise nature of current methods for
diagnosing and monitoring disease which: 1) cannot be performed longitudinally without significant inconvenience to
the patient, 2) are user dependent resulting in variable sensitivity and specificity, 3) have high costs, and 4) can be
invasive. Further, all existing approaches are unable to determine the presence of microscopic residual disease and have
poor individualized prognostic capacity in the post-operative period. Liquid biopsy approaches allow non-invasive,
rapid, longitudinal monitoring of analytes and hold enormous potential in the pre-, post- and diagnostic cancer settings.
In this proposal we will test the hypothesis that circulating tumor HPV DNA (ctHPVDNA) can be used to accurately
predict disease status at the time of diagnosis and in the immediate post-operative period. To test this hypothesis, we
have established a multi-institutional collaboration of HPVmOPSCC biorepositories as well as ongoing prospective
collection. We will: (1) determine the clinical utility of ctHPVDNA at the time of diagnosis with HPVmOPSCC compared to
the gold standard and 2) determine the kinetics of ctHPVDNA in the surgical setting and define the relationship between
ctHPVDNA and clinicopathologic risk factors for recurrence. In doing so, we will fill critical gaps in the field, build
necessary collaborative infrastructure, and generate preliminary data needed to launch a prospective evaluation of
ctHPVDNA as a decision-making tool following surgery in a subsequent R01 application. Such an advance would lead to a
paradigm shift in the management of HPVmOPSCC by enabling personalized treatment de-intensification, with
significant benefit to patients suffering from this disease.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel Faden其他文献
Daniel Faden的其他文献
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{{ truncateString('Daniel Faden', 18)}}的其他基金
Circulating HPV DNA as a Prediagnostic Marker of Oropharyngeal Cancer
循环 HPV DNA 作为口咽癌的预诊断标志物
- 批准号:
10674048 - 财政年份:2022
- 资助金额:
$ 16.8万 - 项目类别:
Cell free HPV DNA detection in the diagnostic and surgical settings
诊断和手术环境中的无细胞 HPV DNA 检测
- 批准号:
10584473 - 财政年份:2022
- 资助金额:
$ 16.8万 - 项目类别:
Circulating HPV DNA as a Prediagnostic Marker of Oropharyngeal Cancer
循环 HPV DNA 作为口咽癌的诊断前标志物
- 批准号:
10526797 - 财政年份:2022
- 资助金额:
$ 16.8万 - 项目类别:
Dissecting temporal and spatial dynamics of immunotherapy resistance
剖析免疫治疗耐药性的时空动态
- 批准号:
10215652 - 财政年份:2021
- 资助金额:
$ 16.8万 - 项目类别:
Dissecting temporal and spatial dynamics of immunotherapy resistance
剖析免疫治疗耐药性的时空动态
- 批准号:
10374916 - 财政年份:2021
- 资助金额:
$ 16.8万 - 项目类别:
Dissecting temporal and spatial dynamics of immunotherapy resistance
剖析免疫治疗耐药性的时空动态
- 批准号:
10584610 - 财政年份:2021
- 资助金额:
$ 16.8万 - 项目类别:
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