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Role of early postnatal exposure to non-persistent pesticides through breast milk on neurodevelopment

产后早期通过母乳接触非持久性农药对神经发育的作用

基本信息

批准号：
10373893
负责人：
Ameer Taha
金额：
$ 19.63万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-21 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10373893
关键词：
Address Agriculture Biological Assay Blood Brain Carbamates Chemicals Child Chlorpyrifos Clinical Cognitive Cognitive deficits Cohort Studies Data Development Enrollment Exposure to Family Foundations Future General Population Goals Half-Life Human Human Milk Impairment Individual Infant Knowledge Lactation Learning Link Mass Spectrum Analysis Maternal Exposure Measurement Measures Milk Modernization Monitor Neurodevelopmental Impairment Neurodevelopmental Problem Organophosphates Outcome Pesticides Policies Postpartum Period Predisposition Pregnant Women Process Research Risk Rodent Role Sampling Serum Suggestion Testing Time Woman Work agricultural pesticide autism spectrum disorder autistic children child bearing cohort early life exposure high risk lipophilicity maternal serum neurobehavioral neurodevelopment offspring pesticide exposure postnatal postnatal period prenatal exposure prospective public health relevance pyrethroid risk mitigation social

项目摘要

PROJECT SUMMARY Non-persistent pesticides are the cornerstone of modern agriculture, yet their routine application is particularly worrisome to child-bearing and lactating women in view of studies linking maternal exposures to increased risk of autism and neurodevelopmental problems in infants. The majority of studies to date have linked prenatal exposures to autism spectrum disorders and impairments in social and cognitive domains. Data on risks associated with early postnatal exposures via breast milk appears to be lacking, despite recent evidence showing the presence of non-persistent pesticides in breast milk. Additionally, it is not known which circulating pesticides accumulate in breast milk, and whether postnatal exposure risks to the infant are elevated for compounds that preferentially partition into breast milk. The goal of this proposal is to quantify an array of non-persistent pesticides in maternal breast milk and serum collected postnatally, in order to 1) relate pesticide concentrations in breast milk to the risk of neurodevelopmental impairments; 2) understand the extent of non-persistent pesticide partitioning from serum into breast milk; and 3) determine whether compounds that preferentially bioconcentrate in milk pose more of a risk to infant neurodevelopment compared to those that partition less. These objectives will be addressed in the “Markers of Autism Risk in Babies - Learning Early Signs” (MARBLES) cohort, which enrolled pregnant mothers who have had a previous child with autism spectrum disorders and therefore are at high risk of delivering another child who develops autism or atypical neurodevelopment in social and cognitive domains. We hypothesize that non-persistent pesticides that highly partition into breast milk, will be associated with increased risk of autism spectrum disorders and atypical neurodevelopment. This research will provide new information on the neurodevelopmental risks associated with early postnatal exposure to non-persistent pesticides, and determine whether these risks are specific to compounds that preferentially partition from blood to breast milk. Identifying non-persistent compounds in breast milk that may adversely impact neurodevelopment in the child, provides the basis for actively monitoring these chemicals in at-risk individuals.

项目总结