Role of early postnatal exposure to non-persistent pesticides through breast milk on neurodevelopment

产后早期通过母乳接触非持久性农药对神经发育的作用

• 批准号: 10373893
• 负责人: Ameer Taha
• 金额: $ 19.63万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-21 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373893
• 关键词: Address; Agriculture; Biological Assay; Blood; Brain; Carbamates; Chemicals; Child; Chlorpyrifos; Clinical; Cognitive; Cognitive deficits; Cohort Studies; Data; Development; Enrollment; Exposure to; Family; Foundations; Future; General Population; Goals; Half-Life; Human; Human Milk; Impairment; Individual; Infant; Knowledge; Lactation; Learning; Link; Mass Spectrum Analysis; Maternal Exposure; Measurement; Measures; Milk; Modernization; Monitor; Neurodevelopmental Impairment; Neurodevelopmental Problem; Organophosphates; Outcome; Pesticides; Policies; Postpartum Period; Predisposition; Pregnant Women; Process; Research; Risk; Rodent; Role; Sampling; Serum; Suggestion; Testing; Time; Woman; Work; agricultural pesticide; autism spectrum disorder; autistic children; child bearing; cohort; early life exposure; high risk; lipophilicity; maternal serum; neurobehavioral; neurodevelopment; offspring; pesticide exposure; postnatal; postnatal period; prenatal exposure; prospective; public health relevance; pyrethroid; risk mitigation; social

PROJECT SUMMARY Non-persistent pesticides are the cornerstone of modern agriculture, yet their routine application is particularly worrisome to child-bearing and lactating women in view of studies linking maternal exposures to increased risk of autism and neurodevelopmental problems in infants. The majority of studies to date have linked prenatal exposures to autism spectrum disorders and impairments in social and cognitive domains. Data on risks associated with early postnatal exposures via breast milk appears to be lacking, despite recent evidence showing the presence of non-persistent pesticides in breast milk. Additionally, it is not known which circulating pesticides accumulate in breast milk, and whether postnatal exposure risks to the infant are elevated for compounds that preferentially partition into breast milk. The goal of this proposal is to quantify an array of non-persistent pesticides in maternal breast milk and serum collected postnatally, in order to 1) relate pesticide concentrations in breast milk to the risk of neurodevelopmental impairments; 2) understand the extent of non-persistent pesticide partitioning from serum into breast milk; and 3) determine whether compounds that preferentially bioconcentrate in milk pose more of a risk to infant neurodevelopment compared to those that partition less. These objectives will be addressed in the “Markers of Autism Risk in Babies - Learning Early Signs” (MARBLES) cohort, which enrolled pregnant mothers who have had a previous child with autism spectrum disorders and therefore are at high risk of delivering another child who develops autism or atypical neurodevelopment in social and cognitive domains. We hypothesize that non-persistent pesticides that highly partition into breast milk, will be associated with increased risk of autism spectrum disorders and atypical neurodevelopment. This research will provide new information on the neurodevelopmental risks associated with early postnatal exposure to non-persistent pesticides, and determine whether these risks are specific to compounds that preferentially partition from blood to breast milk. Identifying non-persistent compounds in breast milk that may adversely impact neurodevelopment in the child, provides the basis for actively monitoring these chemicals in at-risk individuals.

项目摘要 非持久性农药是现代农业的基石，但它们的常规应用尤其受到人们的关注。 鉴于研究表明母亲接触与风险增加有关， 自闭症和婴儿神经发育问题。迄今为止，大多数研究都将产前 接触自闭症谱系障碍以及社交和认知领域的障碍。风险数据 尽管最近有证据表明， 母乳中存在非持久性农药。此外，目前还不知道哪些循环农药 在母乳中积累，以及婴儿出生后接触这些化合物的风险是否会升高， 优先分配到母乳中。这个建议的目标是量化一个非持久性的数组， 产后采集的母亲母乳和血清中的农药，以便1）将农药浓度 （2）了解非持久性农药的危害程度 从血清中分配到母乳中;以及3）确定优先生物浓缩的化合物是否 在牛奶中的一个构成更多的风险婴儿神经发育相比，那些分区较少。这些目标 将在“婴儿自闭症风险标记-学习早期迹象”（MARBLES）队列中进行讨论， 登记的孕妇谁有一个以前的孩子患有自闭症谱系障碍，因此在 分娩另一个患有自闭症或社会和认知方面非典型神经发育的孩子的风险高 域.我们假设，非持久性农药，高度分配到母乳中，将与 自闭症谱系障碍和非典型神经发育的风险增加。这项研究将提供新的 与出生后早期接触非持久性 农药，并确定这些风险是否是特定的化合物，优先从血液中分离 母乳。确定母乳中可能对神经发育产生不利影响的非持久性化合物 在儿童中，为积极监测这些化学品在高危人群中的作用提供了基础。