Role of early postnatal exposure to non-persistent pesticides through breast milk on neurodevelopment

项目总结 非持久性农药是现代农业的基石，但其常规使用尤为重要。 育龄妇女和哺乳期妇女担忧，因为研究将母亲暴露与风险增加联系在一起 婴儿的自闭症和神经发育问题。到目前为止，大多数研究都将产前 暴露于自闭症谱系障碍以及社交和认知领域的障碍。关于风险的数据 尽管最近的证据表明，与出生后早期接触母乳有关的研究似乎是缺乏的。 母乳中存在非持久性农药。此外，目前还不知道哪些流通中的杀虫剂 在母乳中积聚的化合物，以及出生后接触到婴儿的风险是否会增加 优先将其分割成母乳。该提案目标是量化一组非持久性的 母亲母乳和出生后采集的血清中的农药，以1)与农药浓度相关 母乳中非持久性农药对神经发育损害的风险；2)了解非持久性农药的程度 从血清中分离到母乳中；以及3)确定优先生物浓缩的化合物 与那些分割较少的乳汁相比，乳汁中的乳汁对婴儿神经发育构成更大的风险。这些目标 将在“婴儿自闭症风险的标记物--学习早期征兆”(大理石)队列中解决 登记的怀孕母亲，以前的孩子患有自闭症谱系障碍，因此在 生下另一个患有自闭症或社交和认知方面神经发育不典型的孩子的风险很高 域名。我们假设，高度分解到母乳中的非持久性杀虫剂将与 自闭症谱系障碍和非典型神经发育的风险增加。这项研究将提供新的 与出生后早期接触非持久性药物有关的神经发育风险的信息 杀虫剂，并确定这些风险是否特定于优先从血液中分离出来的化合物 为了母乳。识别母乳中可能对神经发育产生不利影响的非持久性化合物 在儿童体内，为积极监测高危个体的这些化学物质提供了基础。

PROJECT SUMMARY Non-persistent pesticides are the cornerstone of modern agriculture, yet their routine application is particularly worrisome to child-bearing and lactating women in view of studies linking maternal exposures to increased risk of autism and neurodevelopmental problems in infants. The majority of studies to date have linked prenatal exposures to autism spectrum disorders and impairments in social and cognitive domains. Data on risks associated with early postnatal exposures via breast milk appears to be lacking, despite recent evidence showing the presence of non-persistent pesticides in breast milk. Additionally, it is not known which circulating pesticides accumulate in breast milk, and whether postnatal exposure risks to the infant are elevated for compounds that preferentially partition into breast milk. The goal of this proposal is to quantify an array of non-persistent pesticides in maternal breast milk and serum collected postnatally, in order to 1) relate pesticide concentrations in breast milk to the risk of neurodevelopmental impairments; 2) understand the extent of non-persistent pesticide partitioning from serum into breast milk; and 3) determine whether compounds that preferentially bioconcentrate in milk pose more of a risk to infant neurodevelopment compared to those that partition less. These objectives will be addressed in the “Markers of Autism Risk in Babies - Learning Early Signs” (MARBLES) cohort, which enrolled pregnant mothers who have had a previous child with autism spectrum disorders and therefore are at high risk of delivering another child who develops autism or atypical neurodevelopment in social and cognitive domains. We hypothesize that non-persistent pesticides that highly partition into breast milk, will be associated with increased risk of autism spectrum disorders and atypical neurodevelopment. This research will provide new information on the neurodevelopmental risks associated with early postnatal exposure to non-persistent pesticides, and determine whether these risks are specific to compounds that preferentially partition from blood to breast milk. Identifying non-persistent compounds in breast milk that may adversely impact neurodevelopment in the child, provides the basis for actively monitoring these chemicals in at-risk individuals.