Analysis of mouse models of premature glial senescence

项目摘要 CNS神经胶质细胞，包括少突胶质细胞、星形胶质细胞和小胶质细胞，调节神经元功能。虽然我们知道 关于它们在发育中和成年CNS中的重要性，关于衰老的胶质细胞如何在中枢神经系统中发挥作用， 导致髓鞘再生失败和神经退化。这与年龄相关的神经退行性疾病特别相关。 疾病，如继发性进行性多发性硬化症（MS）、阿尔茨海默病（AD）和帕金森病（PD） 其中CNS内的神经胶质功能障碍和慢性炎症是常见特征。为全面了解 老年神经胶质细胞对中枢神经系统功能的影响，该项目的目标是表征中枢神经系统神经胶质细胞衰老的新模型， 小鼠并检查其对CNS功能和修复的影响。

Project Summary CNS glial cells, including oligodendrocytes, astrocytes and microglia, regulate neuronal function. Although much is known about their importance in the developing and adult CNS, a gap in knowledge remains with regards to how aged glia contribute to remyelination failure and neurodegeneration. This is particularly relevant to age related neurodegenerative disorders, such as secondary progressive multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD) in which glial dysfunction and chronic inflammation within the CNS, are common features. In order to fully understand the impact of aged glia on CNS function, the goal of this project is to characterize novel models of CNS glial senescence in mice and examine their impact on CNS function and repair.