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Analysis of mouse models of premature glial senescence

胶质细胞早衰小鼠模型分析

基本信息

批准号：
10373179
负责人：
Jeffrey K Huang
金额：
$ 23.4万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10373179
关键词：
Adult Affect Aging Alzheimer&apos s Disease Animals Apoptosis Astrocytes Astrocytosis Axon Biological Assay Brain Cell Aging Cell Differentiation process Cell Lineage Cell Proliferation Cells Central Nervous System Diseases Chronic Dasatinib Data Demyelinations Development Disease Disease Progression Double Minutes Elderly Electron Microscopy Environment Exhibits Failure Functional disorder Future Galactosidase Gene Expression Profile Genes Genomic Instability Glial Fibrillary Acidic Protein Goals Human Impairment Individual Inflammation Injections Knowledge Lead Lesion Lysophosphatidylcholines Mediating Microglia Modeling Molecular Multiple Sclerosis Mus Mutation Nerve Degeneration Neurodegenerative Disorders Neuroglia Neurons Nuclear RNA Oligodendroglia Parkinson Disease Population Premature aging syndrome Quercetin RiboTag Role Secondary Progressive Multiple Sclerosis Spinal Cord Spinal Cord Lesions Stains TP53 gene Tamoxifen Testing Tissues Transcript Western Blotting Wild Type Mouse age related age related neurodegeneration aged brain health differential expression immunoregulation improved mouse model multicatalytic endopeptidase complex nervous system disorder novel oligodendrocyte lineage oligodendrocyte precursor preclinical study precursor cell premature prevent progressive neurodegeneration remyelination repaired senescence transcriptome sequencing ubiquitin-protein ligase young adult

项目摘要

Project Summary CNS glial cells, including oligodendrocytes, astrocytes and microglia, regulate neuronal function. Although much is known about their importance in the developing and adult CNS, a gap in knowledge remains with regards to how aged glia contribute to remyelination failure and neurodegeneration. This is particularly relevant to age related neurodegenerative disorders, such as secondary progressive multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD) in which glial dysfunction and chronic inflammation within the CNS, are common features. In order to fully understand the impact of aged glia on CNS function, the goal of this project is to characterize novel models of CNS glial senescence in mice and examine their impact on CNS function and repair.

项目摘要 CNS神经胶质细胞，包括少突胶质细胞、星形胶质细胞和小胶质细胞，调节神经元功能。虽然我们知道关于它们在发育中和成年CNS中的重要性，关于衰老的胶质细胞如何在中枢神经系统中发挥作用，导致髓鞘再生失败和神经退化。这与年龄相关的神经退行性疾病特别相关。疾病，例如继发性进行性多发性硬化症（MS）、阿尔茨海默病（AD）和帕金森病（PD）其中CNS内的神经胶质功能障碍和慢性炎症是常见特征。为全面了解老年神经胶质细胞对中枢神经系统功能的影响，该项目的目标是表征中枢神经系统神经胶质细胞衰老的新模型，小鼠并检查其对CNS功能和修复的影响。