Analysis of mouse models of premature glial senescence

胶质细胞早衰小鼠模型分析

• 批准号: 10373179
• 负责人: Jeffrey K Huang
• 金额: $ 23.4万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373179
• 关键词: Adult; Affect; Aging; Alzheimer' s Disease; Animals; Apoptosis; Astrocytes; Astrocytosis; Axon; Biological Assay; Brain; Cell Aging; Cell Differentiation process; Cell Lineage; Cell Proliferation; Cells; Central Nervous System Diseases; Chronic; Dasatinib; Data; Demyelinations; Development; Disease; Disease Progression; Double Minutes; Elderly; Electron Microscopy; Environment; Exhibits; Failure; Functional disorder; Future; Galactosidase; Gene Expression Profile; Genes; Genomic Instability; Glial Fibrillary Acidic Protein; Goals; Human; Impairment; Individual; Inflammation; Injections; Knowledge; Lead; Lesion; Lysophosphatidylcholines; Mediating; Microglia; Modeling; Molecular; Multiple Sclerosis; Mus; Mutation; Nerve Degeneration; Neurodegenerative Disorders; Neuroglia; Neurons; Nuclear RNA; Oligodendroglia; Parkinson Disease; Population; Premature aging syndrome; Quercetin; RiboTag; Role; Secondary Progressive Multiple Sclerosis; Spinal Cord; Spinal Cord Lesions; Stains; TP53 gene; Tamoxifen; Testing; Tissues; Transcript; Western Blotting; Wild Type Mouse; age related; age related neurodegeneration; aged; brain health; differential expression; immunoregulation; improved; mouse model; multicatalytic endopeptidase complex; nervous system disorder; novel; oligodendrocyte lineage; oligodendrocyte precursor; preclinical study; precursor cell; premature; prevent; progressive neurodegeneration; remyelination; repaired; senescence; transcriptome sequencing; ubiquitin-protein ligase; young adult

Project Summary CNS glial cells, including oligodendrocytes, astrocytes and microglia, regulate neuronal function. Although much is known about their importance in the developing and adult CNS, a gap in knowledge remains with regards to how aged glia contribute to remyelination failure and neurodegeneration. This is particularly relevant to age related neurodegenerative disorders, such as secondary progressive multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD) in which glial dysfunction and chronic inflammation within the CNS, are common features. In order to fully understand the impact of aged glia on CNS function, the goal of this project is to characterize novel models of CNS glial senescence in mice and examine their impact on CNS function and repair.

项目总结