Core B: Clinical Core

临床核心：核心B--项目摘要/摘要 约翰霍普金斯阿尔茨海默病研究中心(JHADRC)的临床核心(核心B)有七个 具体目标，包括：(1)与外联一起招募和跟踪不同的主题群 征聘和接洽核心(核心E)；将优先考虑保持约30% 在研究对象中代表少数族裔，主要是非洲裔美国人；(2)执行年度 登记的参与者的标准化医学、神经学、精神病学和神经心理学评估 JHADRC，(3)协助Biomarker Core(Core F)收集和存储血液和脑脊液 (CSF)JHADRC参与者的样本和磁共振成像(MRI)扫描，(3)提供 与JHADRC相关的IRB批准的研究的特征良好的对象，(4)与 神经病理学核心(核心D)，以保持较高的尸检率(70%的死者尸检)，(6)至 参与与其他ADRC的合作研究，包括与ADRD相关的多中心研究，以及 (7)与数据核心(核心C)和BiomMarker核心合作，共享临床数据、脑图像和 国家阿尔茨海默病协调中心(NACC)和国家阿尔茨海默病集中中心的标本 疾病资料库(NCRAD)。通过这些努力，核心B力求：(1)支持相关的调查人员 与拥有关键资源的JHADRC合作，(2)促进新的和扩大的地方和国家研究活动， 以及(3)促进年轻研究人员的培训，包括那些通过研究教育得到支持的人 组件(REC)。

CLINICAL CORE: CORE B - PROJECT SUMMARY/ ABSTRACT The Clinical Core (Core B) of the Johns Hopkins Alzheimer's Disease Research Center (JHADRC) has seven specific aims, including: (1) to recruit and follow a diverse cohort of subjects, working with the Outreach Recruitment and Engagement Core (Core E); priority will be given to maintaining approximately 30% representation of minorities, primarily African-Americans, among the study subjects; (2) to perform annual standardized medical, neurologic, psychiatric and neuropsychological evaluations of the participants enrolled in the JHADRC, (3) assist the Biomarker Core (Core F) in collecting and storing blood and cerebrospinal fluid (CSF) specimens and magnetic resonance imaging (MRI) scans from JHADRC participants, (3) to provide well-characterized subjects to IRB-approved research associated with the JHADRC, (4) working with the Neuropathology Core (Core D), to maintain a high autopsy rate (>70% of deceased autopsied), (6) to participate in collaborative research with other ADRCs, including multi-center research related to ADRD, and (7) working with the Data Core (Core C) and the Biomarker Core, share clinical data, brain images and specimens with the National Alzheimer Coordinating Center (NACC) and the National Centralized Alzheimer's Disease Repository (NCRAD). Through these efforts, Core B strives to: (1) support investigators associated with the JHADRC with key resources, (2) promote new and expanded research activities locally and nationally, and (3) facilitate training of young investigators, including those supported through the Research Education Component (REC).