Core B: Clinical Core

临床核心：核心B -项目总结/摘要 约翰霍普金斯阿尔茨海默病研究中心（JHADRC）的临床核心（核心B）有七个 具体目标，包括：（1）与外联方案合作，招募和跟踪一批不同的受试者 招聘和参与核心（核心E）;将优先保持约30% 少数民族，主要是非洲裔美国人，在研究对象中的代表性;（2）每年进行一次 参与者的标准化医学、神经病学、精神病学和神经心理学评估 JHADRC，（3）协助生物标志物核心（核心F）收集和储存血液和脑脊液 (CSF)来自JHADRC参与者的标本和磁共振成像（MRI）扫描，（3）提供 与JHADRC相关的IRB批准的研究的特征良好的受试者，（4）与JHADRC合作 神经病理学核心（核心D），以保持较高的尸检率（>70%的死者尸检），（6） 参与与其他ADRC的合作研究，包括与ADRD相关的多中心研究，以及 (7)与数据核心（核心C）和生物标志物核心合作，共享临床数据，大脑图像， 国家阿尔茨海默病协调中心（NACC）和国家集中阿尔茨海默病 疾病储存库（NCRAD）。通过这些努力，核心B努力：（1）支持相关研究者 与拥有关键资源的JHADRC合作，（2）在当地和全国范围内促进新的和扩大的研究活动， 以及（3）促进年轻研究人员的培训，包括通过研究教育支持的年轻研究人员 组件（REC）。

CLINICAL CORE: CORE B - PROJECT SUMMARY/ ABSTRACT The Clinical Core (Core B) of the Johns Hopkins Alzheimer's Disease Research Center (JHADRC) has seven specific aims, including: (1) to recruit and follow a diverse cohort of subjects, working with the Outreach Recruitment and Engagement Core (Core E); priority will be given to maintaining approximately 30% representation of minorities, primarily African-Americans, among the study subjects; (2) to perform annual standardized medical, neurologic, psychiatric and neuropsychological evaluations of the participants enrolled in the JHADRC, (3) assist the Biomarker Core (Core F) in collecting and storing blood and cerebrospinal fluid (CSF) specimens and magnetic resonance imaging (MRI) scans from JHADRC participants, (3) to provide well-characterized subjects to IRB-approved research associated with the JHADRC, (4) working with the Neuropathology Core (Core D), to maintain a high autopsy rate (>70% of deceased autopsied), (6) to participate in collaborative research with other ADRCs, including multi-center research related to ADRD, and (7) working with the Data Core (Core C) and the Biomarker Core, share clinical data, brain images and specimens with the National Alzheimer Coordinating Center (NACC) and the National Centralized Alzheimer's Disease Repository (NCRAD). Through these efforts, Core B strives to: (1) support investigators associated with the JHADRC with key resources, (2) promote new and expanded research activities locally and nationally, and (3) facilitate training of young investigators, including those supported through the Research Education Component (REC).