Core B: Clinical Core

核心 B：临床核心

• 批准号: 10591546
• 负责人: CONSTANTINE G LYKETSOS
• 金额: $ 124.17万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591546
• 关键词: African American population; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapeutic; Autopsy; Biological; Biological Markers; Blood; Brain; Brain imaging; Cerebrospinal Fluid; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Cognition; Cognition Disorders; Cognitive; Collection; Complex; Consent; Data; Dementia; Diagnosis; Disease; Evaluation; Frontotemporal Lobar Degenerations; Funding; Genotype; Image; Institutional Review Boards; Investigation; Lead; Liquid substance; MRI Scans; Measurement; Medical; Minority; Mission; Neurologic; Neuropsychology; Participant; Pathologic; Patients; Phase; Research; Research Activity; Research Design; Research Institute; Research Personnel; Research Subjects; Resource Sharing; Resources; Sampling; Site; Specimen; Standardization; Study Subject; Therapeutic Clinical Trial; Training; Translational Research; United States National Institutes of Health; Work; biomarker development; brain magnetic resonance imaging; brain tissue; cohort; cooperative study; data sharing; education research; interest; meetings; neuroimaging; neuropathology; operation; outreach; participant enrollment; recruit; repository; success; therapy development

CLINICAL CORE: CORE B - PROJECT SUMMARY/ ABSTRACT The Clinical Core (Core B) of the Johns Hopkins Alzheimer's Disease Research Center (JHADRC) has seven specific aims, including: (1) to recruit and follow a diverse cohort of subjects, working with the Outreach Recruitment and Engagement Core (Core E); priority will be given to maintaining approximately 30% representation of minorities, primarily African-Americans, among the study subjects; (2) to perform annual standardized medical, neurologic, psychiatric and neuropsychological evaluations of the participants enrolled in the JHADRC, (3) assist the Biomarker Core (Core F) in collecting and storing blood and cerebrospinal fluid (CSF) specimens and magnetic resonance imaging (MRI) scans from JHADRC participants, (3) to provide well-characterized subjects to IRB-approved research associated with the JHADRC, (4) working with the Neuropathology Core (Core D), to maintain a high autopsy rate (>70% of deceased autopsied), (6) to participate in collaborative research with other ADRCs, including multi-center research related to ADRD, and (7) working with the Data Core (Core C) and the Biomarker Core, share clinical data, brain images and specimens with the National Alzheimer Coordinating Center (NACC) and the National Centralized Alzheimer's Disease Repository (NCRAD). Through these efforts, Core B strives to: (1) support investigators associated with the JHADRC with key resources, (2) promote new and expanded research activities locally and nationally, and (3) facilitate training of young investigators, including those supported through the Research Education Component (REC).

临床核心：核心 B - 项目摘要/摘要 约翰霍普金斯大学阿尔茨海默病研究中心 (JHADRC) 的临床核心（核心 B）有七个 具体目标，包括：(1) 与外展合作，招募和跟踪不同的受试者群体 招聘和参与核心（核心 E）；优先维持30%左右 研究对象中少数群体（主要是非裔美国人）的代表性； (2) 执行年度 对参加的参与者进行标准化的医学、神经病学、精神病学和神经心理学评估 JHADRC，（3）协助生物标记核心（Core F）收集和储存血液和脑脊液 JHADRC 参与者的 (CSF) 标本和磁共振成像 (MRI) 扫描，(3) 提供 经 IRB 批准的与 JHADRC 相关的研究的特征明确的受试者，(4) 与 神经病理学核心（核心 D），维持高尸检率（>70% 的死者尸检），(6) 参与与其他 ADRC 的合作研究，包括与 ADRD 相关的多中心研究，以及 （7）与Data Core（Core C）和Biomarker Core合作，共享临床数据、大脑图像和 国家阿尔茨海默氏症协调中心 (NACC) 和国家阿尔茨海默氏症集中中心的标本 疾病库（NCRAD）。通过这些努力，Core B 致力于：(1) 支持相关研究人员 与拥有关键资源的 JHADRC 合作，(2) 在本地和全国范围内促进新的和扩大的研究活动， (3) 促进年轻研究人员的培训，包括通过研究教育支持的年轻研究人员的培训 组件（REC）。