Neuroinflammation, Neuronal IL-1R1, and Behavior

项目概要 神经炎症是大多数中枢神经系统疾病（包括神经退行性疾病）的重要诱因 疾病和心理障碍。神经炎症的一个标志是 大脑中的促炎细胞因子白介素-1 (IL-1)。 IL-1 如何引起神经和精神疾病 人们对病理学知之甚少。我们最近发现IL-1的受体IL-1R1是 在大脑中特定的神经元组中表达。这些神经元 IL-1R1、nIL-1R1 调节神经元 通过非规范信号传导途径改变神经元功能和电路连接的活动。这个 应用程序旨在：1) 绘制 nIL-1R1 在大脑中的分布图，2) 展示 nIL-1R1 在神经炎症诱导的行为缺陷和神经病理学中的作用，以及 3) 阐明 nIL-1R1 介导的神经调节机制。

Project Summary Neuroinflammation is a significant contributor to most CNS disorders including neurodegenerative diseases and psychological disorders. A hallmark of neuroinflammation is the increased expression of the proinflammatory cytokine interleukin-1 (IL-1) in the brain. How IL-1 causes neuro- and psycho- pathologies is poorly understood. We have recently discovered that the receptor for IL-1, IL-1R1, is expressed in specific sets of neurons in the brain. These neuronal IL-1R1s, nIL-1R1, modulate neuronal activity via non-canonical signaling pathways to alter neuronal function and circuit connectivity. This application is designed to: 1) map nIL-1R1 distribution in the brain, 2)demonstrate the involvement of nIL-1R1 in neuroinflammation induced behavioral deficits and neuropathology, and 3) elucidate the mechanisms of nIL-1R1 mediated neuromodulation.