Development of a 3D multi-modal perfusion-thermal electrode system

3D多模态灌注热电极系统的开发

基本信息

批准号：
10373924
负责人：
XIAOMING YANG
金额：
$ 60.89万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10373924
关键词：
3-Dimensional Ablation Achievement Address Animal Model Cell membrane Cells Clinical Development Dose Electrodes Embolism Ensure Fracture Genes Goals Heat shock proteins Heating Hyperthermia Immunotherapy Intervention Length of Stay Lesion Liver Liver neoplasms Malignant - descriptor Malignant Neoplasms Membrane Metabolism Methods Microsatellite Repeats Modeling Neoplasm Metastasis Organ Oryctolagus cuniculus Pathway interactions Patients Perfusion Peripheral Permeability Primary Neoplasm Protocols documentation Pump Quality of life Radiofrequency Interstitial Ablation Recurrence Recurrent disease Residual Tumors Residual state Risk Safety Series Solid Source Structure Surgical margins System Techniques Technology Temperature Testing Therapeutic Therapeutic Agents Therapeutic Intervention Thermal Ablation Therapy Tissues Treatment Failure Tumor Tissue Unresectable Venous advanced system antitumor agent biomaterial compatibility cost effectiveness design efficacious intervention efficacy evaluation experimental study gene therapy image guided image guided intervention improved in vivo innovation microwave ablation minimally invasive multimodality neoplastic cell novel pre-clinical preclinical study prevent radiofrequency hyperthermia success technique development technology development tool tumor tumor ablation

项目摘要

Summary/Abstract: Title: Development of a 3D multi-modal perfusion-thermal electrode system Advances in image-guided interventional technologies have greatly improved the management of malignancies in patients. Among different interventional oncologic techniques, thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), have become the principal tools for treatment of unresectable primary and metastatic malignancies. However, tumor recurrence post- thermal ablation of medium (3-5 cm) to large (5-7 cm) lesions often occurs due to incomplete ablation of tumor margins. To date, there is no an ideal image-guided interventional method for effective management of medium-to-large solid organ malignancies. This project is specifically designed to conquer the critical clinical problem ─ persistence or recurrence of medium-to-large malignancies post-thermal ablation, by development of a novel three- dimensional (3D) multi-modal perfusion-thermal electrode system. To this end, we have proposed two specific goals: (1) Aim I: to design and develop the novel 3D multi-modal perfusion-thermal electrode system that is specifically built for using RFA-induced peri-tumoral RF hyperthermia (RFH) to enhance direct chemotherapeutic destruction of tumor margins; and (2) Aim II: to validate the technical feasibility of the new multi-modal electrode system with optimizing the technical protocols via serial preclinical studies in living animal models with orthotopic liver tumors. As the first step of the new technique development, we will primarily focus on the treatment of hepatic tumors by using first- line chemotherapeutics. If successful, we will extend its application in treating malignancies to other organs with more advanced therapies, such as gene therapy and immunotherapy. The success of this project will revolutionize current thermal ablation technology, leading to significant advancement in eradicating medium-to-large malignant lesions, not only in the liver but also in other solid organs. This will, in turn, greatly improve survival and quality of life of patients suffering from medium-to-large malignancies.

摘要/摘要：标题：3D多模式灌注热电极系统的开发图像引导的介入技术的进步极大地改善了管理患者的恶性肿瘤。在不同的介入肿瘤学技术中，热消融，此类由于射频消融（RFA）和微波炉消融（MWA）已成为主要工具治疗不可切除的原发性和转移性恶性肿瘤。但是，肿瘤复发培养基（3-5厘米）向大（5-7厘米）病变的热消融通常是由于不完全消融而发生的肿瘤边缘。迄今为止，没有理想的图像引导介入方法可以有效中等到大型固体器官恶性肿瘤的管理。该项目是专门设计用于征服关键临床问题的 - 持久性或热消融后中等到大型恶性肿瘤的复发，通过开发新颖的三个尺寸（3D）多模式灌注热电极系统。为此，我们提出了两个特定目标：（1）目标I：设计和开发新颖的3D多模式灌注 - 热电极专门用于使用RFA诱导的肿瘤周期RF高温（RFH）的系统增强肿瘤边缘的直接化学治疗破坏；（2）目标II：验证通过优化技术协议的新多模式电极系统的技术可行性通过具有原位肝肿瘤的活动物模型中的序列细节研究。作为第一步新技术开发，我们将主要专注于通过首先使用肝肿瘤的治疗线化疗。如果成功，我们将扩展其在治疗Malignancys中的应用具有更晚期疗法的器官，例如基因疗法和免疫疗法。该项目的成功将彻底改变当前的热消融技术，从而导致根除中等到大的恶性病变方面的显着进步，不仅在肝脏中，而且在也在其他固体器官中。反过来，这将大大改善患者的生存和生活质量患有中度到大的恶性肿瘤。