Development of a 3D multi-modal perfusion-thermal electrode system

摘要/摘要： 三维多模式灌注-热电极系统的研制 影像引导介入技术的进步极大地改善了对 病人中的恶性肿瘤。在不同的介入肿瘤学技术中，热消融，如 作为射频消融(RFA)和微波消融(MWA)的主要工具 不能切除的原发和转移性恶性肿瘤的治疗。然而，术后肿瘤复发 中(3-5厘米)到大(5-7厘米)病变的热消融通常是由于不完全消融。 肿瘤边缘。到目前为止，还没有一种理想的影像引导介入方法来有效地 中大型实体器官恶性肿瘤的治疗。 该项目是专门为攻克关键的临床问题而设计的─持久性或 热消融后中到大型恶性肿瘤的复发，通过开发一种新的三种 三维(3D)多模式灌流-热电极系统。为此，我们提出了两项建议。 具体目标：(1)目标一：设计和研制新型三维多模式灌流-热电极 专门为使用RFA诱导的肿瘤周围射频热疗(RFH)而构建的系统 加强直接化疗对肿瘤边缘的破坏；以及(2)目标II：验证 优化技术方案实现新型多模式电极系统的技术可行性 通过对原位肝肿瘤活体动物模型进行一系列临床前研究。作为该计划的第一步 新技术的发展，我们将主要集中在肝肿瘤的治疗上，第一次- 直线化疗药物。如果成功，我们将把它在治疗恶性肿瘤方面的应用推广到其他 器官有更先进的治疗方法，如基因疗法和免疫疗法。 该项目的成功将使目前的热消融技术发生革命性变化，导致 在根除中到大型恶性病变方面取得了重大进展，不仅在肝脏，而且 也存在于其他固体器官中。反过来，这将极大地提高患者的存活率和生活质量 患有中到大型恶性肿瘤的。

Summary/Abstract: Title: Development of a 3D multi-modal perfusion-thermal electrode system Advances in image-guided interventional technologies have greatly improved the management of malignancies in patients. Among different interventional oncologic techniques, thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), have become the principal tools for treatment of unresectable primary and metastatic malignancies. However, tumor recurrence post- thermal ablation of medium (3-5 cm) to large (5-7 cm) lesions often occurs due to incomplete ablation of tumor margins. To date, there is no an ideal image-guided interventional method for effective management of medium-to-large solid organ malignancies. This project is specifically designed to conquer the critical clinical problem ─ persistence or recurrence of medium-to-large malignancies post-thermal ablation, by development of a novel three- dimensional (3D) multi-modal perfusion-thermal electrode system. To this end, we have proposed two specific goals: (1) Aim I: to design and develop the novel 3D multi-modal perfusion-thermal electrode system that is specifically built for using RFA-induced peri-tumoral RF hyperthermia (RFH) to enhance direct chemotherapeutic destruction of tumor margins; and (2) Aim II: to validate the technical feasibility of the new multi-modal electrode system with optimizing the technical protocols via serial preclinical studies in living animal models with orthotopic liver tumors. As the first step of the new technique development, we will primarily focus on the treatment of hepatic tumors by using first- line chemotherapeutics. If successful, we will extend its application in treating malignancies to other organs with more advanced therapies, such as gene therapy and immunotherapy. The success of this project will revolutionize current thermal ablation technology, leading to significant advancement in eradicating medium-to-large malignant lesions, not only in the liver but also in other solid organs. This will, in turn, greatly improve survival and quality of life of patients suffering from medium-to-large malignancies.