Augmented Reality as an Adjunct to Quitline Counseling for Smoking Cessation

项目摘要/摘要 吸烟仍然是美国发病率和死亡率的主要可预防原因。 开发有效的戒烟干预措施仍然是公共卫生的优先事项，而mHealth提供 有机会减少传播和实施戒烟治疗的障碍。该项目将测试 增强现实(AR)的新兴技术可增强以下个人的戒烟能力 联系佛罗里达无烟草戒烟热线获得治疗服务。AR将虚拟对象插入到现实世界中 在屏幕(例如，智能手机)上查看的环境。线索暴露疗法已证明有效 在实验室中用于减少对烟草的渴望，但这些效果似乎并不能很好地推广到 消光设置。这种灭绝后的“更新效应”在动物和人类身上都得到了证实。 学习。随着AR技术的出现，现在可以对多个物种进行物种灭绝试验 在吸烟者自己的真实世界吸烟环境中。扩大线索效应的潜力-- 暴露在自然环境中为创新和可扩展的戒烟治疗提供了机会 可以远程管理。在R34治疗开发赠款的资助下，研究团队已经 已经开发了一个基于基本AR平台的应用程序。重要的是，我们已经在受控环境中测试了该应用程序 实验发现，AR刺激满足消退线索的关键标准，因为它们：(A)诱发 显著的线索反应性，可与体内线索相媲美，(B)重复暴露线索的次数减少 渴求(即，灭绝)。拟议项目的主要目标是通过调整 临床使用的APP，目的是测试AR与奎宁联合治疗时的疗效，而 还审议了与未来执行有关的关键问题。Aim 1将扩展这款应用程序，使其成为一款吸引人的 为吸烟者提供方便的治疗工具，并协调研究小组之间的所有转诊程序 以及佛罗里达无烟草专线。AIM 2将从佛罗里达无烟草戒烟热线招募参与者，并 随机选择只接受QuiLine服务或接受QuiLine服务和AR应用程序的个人。这个 主要结果是在登记后6个月生化证实的烟草戒断。目标3将 评估治疗实施问题，以指导未来采用戒烟治疗。如果AR应用被证明是 它是有效的，它将准备好通过戒烟热线和其他吸烟方式传播和实施 戒烟计划(例如，传统戒烟咨询、短信干预、其他移动设备 戒烟应用程序)。这项工作有可能为一系列现有的治疗方法提供信息，不仅是对烟草 依赖，但也对其他物质使用障碍和精神健康状况，由 条件反射原理。

PROJECT SUMMARY/ABSTRACT Cigarette smoking remains the leading preventable cause of morbidity and mortality in the United States. Developing effective cessation interventions remains a public health priority, and mHealth offers the opportunity to reduce barriers to dissemination and implementation of cessation treatment. This project will test the emerging technology of augmented reality (AR) to enhance smoking cessation among individuals who contact the Tobacco Free Florida quitline for treatment services. AR inserts virtual objects into the real-world environment as viewed on a screen (e.g., smartphone). Cue-exposure treatments have demonstrated efficacy for decreasing tobacco craving in the laboratory, but these effects do not appear to generalize well beyond the extinction setting. This post-extinction “renewal effect” has been demonstrated in both animal and human studies. With the emergence of AR technology, it is now possible to conduct extinction trials across multiple environments throughout smokers’ own real-world smoking settings. The potential to extend the effects of cue- exposure to naturalistic settings offers the opportunity for an innovative and scalable cessation treatment that can be administered remotely. With funding from an R34 treatment development grant, the research team has already developed an app with the basic AR platform. Importantly, we have tested the app in controlled experiments and found that the AR stimuli satisfied the key criterion for extinction cues in that they: (a) elicited substantial cue-reactivity, comparable to in vivo cues and that (b) repeated exposure to the cues reduced craving (i.e., extinction). The primary goal of the proposed project is to extend this initial work by adapting the app for clinical use, with the objective of testing the efficacy of AR when combined with quitline treatment, while also considering key questions relevant to future implementation. Aim 1 will expand the app to be an engaging and user-friendly treatment tool for smokers, and to coordinate all referral procedures between the study team and the Tobacco Free Florida quitline. Aim 2 will recruit participants from the Tobacco Free Florida quitline and randomize individuals either to receive quitline services only or receive quitline services plus the AR app. The primary outcome is biochemically-confirmed tobacco abstinence at 6 months post-enrollment. Aim 3 will evaluate treatment implementation questions to guide future quitline adoption. If the AR app proves to be efficacious, it will be ready for dissemination and implementation through quitlines as well as other smoking cessation programs (e.g., traditional cessation counseling, text messaging interventions, other mobile cessation apps). This work has the potential to inform a range of existing treatments not only for tobacco dependence, but also for other substance use disorders and mental health conditions that are maintained by principles of conditioning.