Mechanisms underlying atrial fibrillation associated with chronic kidney disease
Mechanisms underlying atrial fibrillation associated with chronic kidney disease
批准号:
10376782
负责人:
Na Li
金额:
$51.06万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-04-15 至 2024-02-29
关键词:
AdultAffectAmericanArrhythmiaAtrial FibrillationCASP1 geneCalciumCardiacCardiac MyocytesCardiovascular systemChronic Kidney FailureConfocal MicroscopyDataDependovirusDevelopmentDiagnosisDietary ProteinsElectric StimulationElectrocardiogramEventExhibitsGoalsHeart AtriumHemorrhageIncidenceInflammasomeInflammationIschemic StrokeKnock-in MouseKnockout MiceMeasuresMediatingMolecularMonitorMorbidity - disease rateMusMuscle CellsNephrectomyPathogenesisPathway interactionsPatientsPharmacologyPhosphorylationPhosphorylation SitePlayPredispositionPrevalencePrevention strategyProteinsPublic HealthRiskRisk FactorsRodent ModelRoleRyanodine Receptor Calcium Release ChannelSinusSiteSourceSterilityStriated MusclesTelemetryTestingTissuesWorkantagonistcardiovascular risk factorcohortdietary manipulationgenetic regulatory proteinknock-downmortalitymouse modelnovelpatch clamppreventreceptorreceptor expressiontargeted treatmenttreatment strategy
中文摘要
项目总结/摘要
慢性肾脏疾病(CKD)是心血管发病率和死亡率的已知预测因子,并且是心血管疾病的危险因素。
心房颤动(AF)的重要危险因素。关于这些疾病的分子机制,
与CKD相关的基础AF。我们的初步数据显示,在细胞内NLRP 3炎性小体的激活,
CKD小鼠模型中分离的心房肌细胞。本项目的长期目标是阐明
小鼠炎症小体激活导致房颤发生的分子和细胞机制
关于CKD我们将检验心房肌内NLRP 3炎性小体激活增强的假设,
心肌细胞通过增加促钙释放,
RyR 2的PEG磷酸化。
英文摘要
PROJECT SUMMARY / ABSTRACT
Chronic kidney disease (CKD) is a known predictor of cardiovascular morbidity and mortality, and is an
important risk factor for atrial fibrillation (AF). Very little remains known about the molecular mechanisms
underlying AF associated with CKD. Our preliminary data reveal activation of the NLRP3 inflammasome within
atrial myocytes isolated in a mouse model of CKD. The long-term goal of this project is to elucidate the
molecular and cellular mechanisms underlying AF development as a result of inflammasome activation in mice
with CKD. We will test the hypothesis that enhanced activation of the NLRP3 inflammasome within atrial
myocytes enhances the susceptibility to AF by promoting proarrhythmogenic Ca2+ releases via increased
SPEG-phosphorylation of RyR2.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Cardiac fibroblast inflammasome and atrial myopathy
-
批准号:10597243
-
项目类别:
-
资助金额:$69.97万
-
财政年份:2022
-
负责人:Na Li
-
依托单位:
The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis
-
批准号:10531927
-
项目类别:
-
资助金额:$66.39万
-
财政年份:2021
-
负责人:Na Li
-
依托单位:
The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis
-
批准号:10363449
-
项目类别:
-
资助金额:$67.89万
-
财政年份:2021
-
负责人:Na Li
-
依托单位:
The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis
-
批准号:10779536
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2021
-
负责人:Na Li
-
依托单位:
Mechanisms underlying atrial fibrillation associated with chronic kidney disease
-
批准号:9913385
-
项目类别:
-
资助金额:$51.06万
-
财政年份:2019
-
负责人:Na Li
-
依托单位:
Inflammasome mediated pathogenesis of atrial fibrillation
-
批准号:9336416
-
项目类别:
-
资助金额:$39.63万
-
财政年份:2016
-
负责人:Na Li
-
依托单位:
New Building Blocks for the Synthesis of Modified RNAs
-
批准号:8252504
-
项目类别:
-
资助金额:$18.01万
-
财政年份:2012
-
负责人:Na Li
-
依托单位:
海外基金