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Improving Kidney Health Assessment in Young Patients with Spina Bifida

改善年轻脊柱裂患者的肾脏健康评估

基本信息

批准号：
10378062
负责人：
David Chu
金额：
$ 19.01万
依托单位：
LURIE CHILDREN'S HOSPITAL OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10378062
关键词：
Address Adolescent and Young Adult Adult Advisory Committees Affect Assessment tool Attitude Award Belief Bladder Cardiovascular Diseases Caregivers Caring Catheterization Centers for Disease Control and Prevention (U.S.)Cessation of life Childhood Chronic Kidney Failure Clinic Collaborations Congenital Abnormality Consensus Data Detection Development Development Plans Disease Progression Disease Surveillance Doctor of Philosophy Educational Intervention Educational workshop End stage renal failure Ensure Environment Equation Evaluation Extramural Activities Feasibility Studies Fostering Foundations Funding Future Glomerular Filtration Rate Goals Gold Guidelines Health Healthcare Impairment Infant Institutes Intervention Interview Iohexol K-Series Research Career Programs Kidney Knowledge Lead Measures Medicine Mentors Mentorship Methodology Modeling Neurogenic Bladder Operative Surgical Procedures Patients Pediatric Hospitals Plasma Population Positioning Attribute Predisposition Process Prospective cohort study Protocols documentation Provider Public Health Qualitative Research Reconstructive Surgical Procedures Registries Renal function Reporting Research Research Infrastructure Research Methodology Research Personnel Research Support Resources Review Literature Science Scientist Self Care Severities Spinal Dysraphism Structure Surgeon Surveillance Methods Testing Theoretical model Time Training Translating Uncertainty United States Universities Urology Validation career career development clinical epidemiology clinical practice clinical translation cohort cost diagnostic strategy diagnostic tool experience future implementation health assessment health belief health literacy high risk population implementation facilitators implementation intervention implementation research implementation science implementation study improved improved outcome informant insight instrument kidney preservation multidisciplinary novel patient engagement patient oriented patient oriented research predictive modeling preference pressure prevent programs provider factors reduced muscle mass skills standard measure surveillance strategy systematic review tool urologic validation studies

项目摘要

PROJECT SUMMARY This Career Development Award will help David I. Chu, MD, MSCE, become an independent surgeon-scientist who will develop the evidence to improve kidney, bladder, and overall health in young patients with spina bifida. Dr. Chu will use this award to build on his existing foundation in clinical epidemiology to achieve five career development goals: 1) Develop expertise in patient-oriented research (POR); 2) Acquire experience in qualitative research; 3) Gain knowledge in creating and implementing consensus strategies; 4) Strengthen research portfolio and grantsmanship skills; and 5) Build inter-disciplinary, multi-institutional research collaborations. These skills will allow him to translate research into clinical practice to improve outcomes in patients with spina bifida. Dr. Chu will achieve these career objectives through a career development plan that consists of intensive experiential training, structured didactics and workshops, and a comprehensive mentoring program. His Primary Mentor is Dr. Tamara Isakova, an expert in POR in chronic kidney disease with an outstanding record of extramural funding and mentorship. His Co-Mentor is Dr. Earl Cheng, a national leader in pediatric urologic reconstructive surgery and spina bifida care. His Advisory Committee includes interdisciplinary experts in kidney function equations (Dr. Susan Furth, MD, PhD), qualitative research (Dr. Elisa Gordon, PhD, MPH), consensus-building and implementation in surgery (Dr. Mehul Raval, MD, MS), and advanced implementation science methodology (Dr. Justin Smith, PhD). Dr. Chu’s career development plan will be supported by the exceptional institutional environment of Lurie Children’s Hospital and Northwestern University, including the 1) Dedicated resources and research infrastructure within Lurie Children’s Hospital’s Division of Urology and Department of Surgery; 2) Robust, high-volume, and multi-disciplinary Lurie Children’s Hospital Spina Bifida Clinic; and 3) Strong research support from Northwestern University’s Clinical and Translation Sciences Institute and the Institute for Public Health and Medicine. The overall objective of this scientific proposal is to improve kidney health assessment tools and approaches in young patients with spina bifida. Various guidelines prioritize preserving kidney health in these patients, but preliminary evidence suggests that current tools and approaches for assessing kidney health are inaccurate, not patient-centered, and not uniformly implemented by providers. The Aims of this proposal are to: 1) Compare current kidney function estimating equations to gold-standard iohexol plasma clearance tests and develop novel, spina-bifida- specific equations; 2) Assess patient knowledge, attitudes, and beliefs towards kidney health and evaluation, guided by the revised Health Belief Model; and 3) Assess provider preferences, barriers, and facilitators towards kidney health surveillance methods and strategies to create consensus implementation practices. The combination of advanced quantitative, qualitative, and implementation research methods and mentored training will ensure Dr. Chu emerges as a highly successful, independent investigator in spina bifida care.

项目总结