Improving Kidney Health Assessment in Young Patients with Spina Bifida

改善年轻脊柱裂患者的肾脏健康评估

• 批准号: 10597638
• 负责人: David Chu
• 金额: $ 19.01万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597638
• 关键词: Address; Adolescent and Young Adult; Adult; Advisory Committees; Affect; Assessment tool; Attitude; Award; Belief; Bladder; Cardiovascular Diseases; Caregivers; Caring; Catheterization; Centers for Disease Control and Prevention (U.S.); Cessation of life; Childhood; Chronic Kidney Failure; Clinic; Clinical Sciences; Collaborations; Congenital Abnormality; Consensus; Data; Dedications; Detection; Development; Development Plans; Disease Progression; Disease Surveillance; Doctor of Philosophy; Early Diagnosis; Educational Intervention; Educational workshop; End stage renal failure; Ensure; Environment; Equation; Evaluation; Extramural Activities; Feasibility Studies; Fostering; Foundations; Funding; Future; Glomerular Filtration Rate; Goals; Guidelines; Health; Healthcare; Impairment; Infant; Institution; Intervention; Interview; Iohexol; K-Series Research Career Programs; Kidney; Kidney Diseases; Knowledge; Measures; Medicine; Mentors; Mentorship; Methodology; Modeling; Neurogenic Bladder; Operative Surgical Procedures; Patients; Pediatric Hospitals; Plasma; Population; Positioning Attribute; Predisposition; Process; Prospective, cohort study; Protocols documentation; Provider; Public Health; Qualitative Research; Reconstructive Surgical Procedures; Registries; Renal function; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Support; Resources; Review Literature; Scientist; Self Care; Severities; Spinal Dysraphism; Structure; Surgeon; Surveillance Methods; Testing; Theoretical model; Training; Translating; Translational Research; Uncertainty; United States; Universities; Urology; Validation; career; career development; clinical epidemiology; clinical practice; cohort; cost; diagnostic strategy; diagnostic tool; experience; future implementation; health assessment; health belief; health literacy; high risk population; implementation facilitators; implementation intervention; implementation research; implementation science; implementation study; improved; improved outcome; informant; insight; instrument; kidney preservation; multidisciplinary; novel; patient engagement; patient oriented; patient oriented research; predictive modeling; preference; pressure; prevent; programs; provider factors; reduced muscle mass; skills; standard measure; surveillance strategy; systematic review; tool; urologic; validation studies

PROJECT SUMMARY This Career Development Award will help David I. Chu, MD, MSCE, become an independent surgeon-scientist who will develop the evidence to improve kidney, bladder, and overall health in young patients with spina bifida. Dr. Chu will use this award to build on his existing foundation in clinical epidemiology to achieve five career development goals: 1) Develop expertise in patient-oriented research (POR); 2) Acquire experience in qualitative research; 3) Gain knowledge in creating and implementing consensus strategies; 4) Strengthen research portfolio and grantsmanship skills; and 5) Build inter-disciplinary, multi-institutional research collaborations. These skills will allow him to translate research into clinical practice to improve outcomes in patients with spina bifida. Dr. Chu will achieve these career objectives through a career development plan that consists of intensive experiential training, structured didactics and workshops, and a comprehensive mentoring program. His Primary Mentor is Dr. Tamara Isakova, an expert in POR in chronic kidney disease with an outstanding record of extramural funding and mentorship. His Co-Mentor is Dr. Earl Cheng, a national leader in pediatric urologic reconstructive surgery and spina bifida care. His Advisory Committee includes interdisciplinary experts in kidney function equations (Dr. Susan Furth, MD, PhD), qualitative research (Dr. Elisa Gordon, PhD, MPH), consensus-building and implementation in surgery (Dr. Mehul Raval, MD, MS), and advanced implementation science methodology (Dr. Justin Smith, PhD). Dr. Chu’s career development plan will be supported by the exceptional institutional environment of Lurie Children’s Hospital and Northwestern University, including the 1) Dedicated resources and research infrastructure within Lurie Children’s Hospital’s Division of Urology and Department of Surgery; 2) Robust, high-volume, and multi-disciplinary Lurie Children’s Hospital Spina Bifida Clinic; and 3) Strong research support from Northwestern University’s Clinical and Translation Sciences Institute and the Institute for Public Health and Medicine. The overall objective of this scientific proposal is to improve kidney health assessment tools and approaches in young patients with spina bifida. Various guidelines prioritize preserving kidney health in these patients, but preliminary evidence suggests that current tools and approaches for assessing kidney health are inaccurate, not patient-centered, and not uniformly implemented by providers. The Aims of this proposal are to: 1) Compare current kidney function estimating equations to gold-standard iohexol plasma clearance tests and develop novel, spina-bifida- specific equations; 2) Assess patient knowledge, attitudes, and beliefs towards kidney health and evaluation, guided by the revised Health Belief Model; and 3) Assess provider preferences, barriers, and facilitators towards kidney health surveillance methods and strategies to create consensus implementation practices. The combination of advanced quantitative, qualitative, and implementation research methods and mentored training will ensure Dr. Chu emerges as a highly successful, independent investigator in spina bifida care.

项目概要 该职业发展奖将帮助 David I. Chu（医学博士、理学硕士）成为一名独立的外科医生科学家 谁将开发改善年轻脊柱患者的肾脏、膀胱和整体健康的证据 裂。朱博士将利用这一奖项，在其现有的临床流行病学基础上，实现五项目标 职业发展目标： 1）发展以患者为中心的研究（POR）方面的专业知识； 2) 获得以下方面的经验 定性研究； 3）获得制定和实施共识策略的知识； 4) 强化 研究组合和资助技能； 5) 建立跨学科、多机构的研究 合作。这些技能将使他能够将研究转化为临床实践，以改善结果 脊柱裂患者。朱博士将通过职业发展计划实现这些职业目标： 包括强化体验式培训、结构化教学和研讨会以及全面的指导 程序。他的主要导师是 Tamara Isakova 博士，她是慢性肾病 POR 方面的专家， 校外资助和指导的杰出记录。他的共同导师是Earl Cheng博士，一位国家级的领导者。 小儿泌尿外科重建手术和脊柱裂护理。他的顾问委员会包括 肾功能方程跨学科专家（Susan Furth 博士，医学博士、哲学博士）、定性研究（Dr. Susan Furth） Elisa Gordon，博士，公共卫生硕士），外科手术中的共识建立和实施（Mehul Raval 博士，医学博士，理学硕士），以及 先进的实施科学方法（Justin Smith 博士）。褚博士的职业发展规划 将得到卢里儿童医院和西北大学特殊机构环境的支持 大学，包括 1) 卢里儿童医院内的专用资源和研究基础设施 泌尿外科和外科； 2) 稳健、大容量、多学科的 Lurie Children’s 医院脊柱裂诊所； 3）来自西北大学临床和实验室的强大研究支持 翻译科学研究所和公共卫生与医学研究所。本次活动的总体目标 科学建议是改进年轻脊柱患者的肾脏健康评估工具和方法 裂。各种指南优先考虑保护这些患者的肾脏健康，但初步证据 表明当前评估肾脏健康的工具和方法不准确，不以患者为中心， 并且没有由提供商统一实施。该提案的目的是： 1) 比较当前的肾脏 金标准碘海醇血浆清除率测试的函数估计方程并开发新颖的脊柱裂- 具体方程； 2) 评估患者对肾脏健康和评估的知识、态度和信念， 以修订后的健康信念模型为指导； 3) 评估提供商的偏好、障碍和促进因素 制定肾脏健康监测方法和策略，以达成共识的实施实践。这 结合先进的定量、定性和实施研究方法并进行指导 培训将确保朱医生成为脊柱裂护理领域非常成功的独立研究者。