Advanced Training in Community Based Research; training in Bio-informatics, Drug Resistance and Pathogenesis

摘要：以社区为基础的艾滋病研究高级培训 津巴布韦是世界上艾滋病毒感染率最高的国家之一， 有基础的研究可以为改善预防和护理提供宝贵的信息。培养新技能， 分子流行病学和基因组学能力的重点是最佳利用这些资源。培训 基本实验室研究技能，生物信息学，建模和数据科学的跨学科连续体， 相关的伦理研究将解决津巴布韦的国家和NIH/Fogarty的目标。我们提出一个3- 多管齐下的方法： 培养研究技能：我们将为学生和研究生提供短期课程培训， 发展支撑当代社区研究的技能，设计创新研究 整合地理定位、流行病学和分子研究方法，解读艾滋病毒传播数据 和预防我们建议引进和促进生物信息学的使用， 系统发育，宿主和病毒遗传学，可用于解决正在进行的流行病。 为了促进博士水平的研究：我们要求支持5名博士生，从生物，社会 科学或医学学科。在津巴布韦大学注册的学生将确定合适的项目 和导师进行有关艾滋病毒耐药性、基因组学和艾滋病毒发病机制的研究， 社区为基础的研究。支持将包括支付费用和适度的津贴;学术监督 和指导当地和/或国际专家将得到补偿，以确保跨学科的科学 研究生成果的发展和质量。 培养未来的研究领导力。这可以通过支持博士后研究员进行 在一个指导的环境中进行研究，以发展研究管理，指导和授予写作技能， 继续他们的研究生涯。“博士后研究员”的职位在非洲学术界并不常见。 作为一个研究机构，BRTI将允许博士后研究员专注于发展领导技能， 执行和分析正在进行的项目。研究员将设计和管理自己的项目， 研究团队，解释数据，在导师的指导下向同行阐述和展示研究结果， 在任期内完成研究补助金的申请。 这种三管齐下的方法将有效地建立先进的卫生研究能力， 津巴布韦的艾滋病研究。这些活动和培训将着眼于将新的 以科学方法处理儿童、青少年和青年等重点人群的公共卫生优先事项 妇女，在社区环境中。评价战略将包括以下方面的形成性和总结性证据： 活动和产出。结果评估将包括通过学生和研究员的评价 成果、介绍和出版物及其对政策和利益攸关方的影响。

ABSTRACT: Advanced training in Community Based HIV Research In Zimbabwe with one of the highest HIV burdens in the world, data and samples collected in community based research can contribute valuable information to improve prevention and care. Building new skills and capacity for molecular epidemiology and genomics focuses on the best use of these resources. Training in the interdisciplinary continuum of basic lab research skills, bioinformatics, modeling and data science for relevant, ethical research will address Zimbabwe's National and NIH/Fogarty goals. We propose a 3- pronged approach: To develop research skills: We will conduct short course training for students and post-graduates to develop the skills underpinning contemporary community based research, to design innovative studies integrating geolocation, epidemiologic and molecular research methods to interpret data on HIV transmission and prevention. We propose to introduce and promote the use of bioinformatics, to develop skills in phylogenetic, host and viral genetics that can be applied to address the ongoing epidemic. To promote research at doctoral level: We request support for 5 PhD students, from biologic, social science or medical disciplines. Students registered with universities in Zimbabwe will identify suitable projects and mentors to conduct HIV research relevant to Drug resistance, Genomics and Pathogenesis of HIV in community based studies. Support will include payment of fees and a modest stipend; academic supervision and mentoring from local and/or international experts will be compensated to ensure interdisciplinary scientific development and quality of postgraduate outcomes. To develop future research leadership. This can be achieved by supporting postdoctoral fellows to conduct research in a mentored environment to develop research management, mentoring and grant writing skills to sustain their research career. The position of “Postdoctoral Fellow” is uncommon in African academic circles. As a research institution, the BRTI will permit Postdoctoral fellows to focus on developing leadership skills, implementing and analyzing ongoing projects. Fellows will design and manage their own projects and research teams, interpret data, articulate and present findings to peers under the guidance of mentors and complete applications for a research grant during their tenure. This 3-pronged approach will effectively build advanced health research capacity filling critical gaps in current HIV research in Zimbabwe. The activities and training will be directed towards combining new scientific methods to address the public health priorities of key populations: children, adolescents and young women, in community settings. The evaluation strategies will include formative and summative evidence of activity and output. Outcome assessment will encompass through evaluations of student and fellow achievements, presentations and publications, and their impact on policy and stakeholders.