Advanced Training in Community Based Research; training in Bio-informatics, Drug Resistance and Pathogenesis

摘要：社区艾滋病毒研究高级培训 在世界上艾滋病毒负担最高的津巴布韦，在社区收集的数据和样本 基础研究可以为改进预防和护理提供有价值的信息。培养新技能和 分子流行病学和基因组学的能力侧重于对这些资源的最佳利用。培训 基础实验室研究技能、生物信息学、建模和数据科学的跨学科连续体系 相关的伦理研究将涉及津巴布韦的国家目标和国家卫生研究院/福格蒂目标。我们建议3- 双管齐下的方法： 培养研究技能：我们将为学生和研究生举办短期课程培训，以 发展支撑当代社区研究的技能，以设计创新研究 综合地理位置、流行病学和分子研究方法解释艾滋病毒传播数据 和预防。我们建议引入和推广生物信息学的使用，以培养在 可应用于应对持续流行的系统发育、宿主和病毒遗传学。 为了促进博士水平的研究：我们请求为5名博士生提供支持，来自生物、社会 科学或医学学科。在津巴布韦大学注册的学生将确定合适的项目 和导师进行与艾滋病毒耐药性、基因组学和艾滋病毒致病机理有关的艾滋病毒研究 基于社区的研究。支持将包括支付学费和适中的津贴；学术指导 来自当地和/或国际专家的指导将得到补偿，以确保跨学科的科学 研究生成果的发展和质量。 培养未来的研究领导力。这可以通过支持博士后研究员进行 在有指导的环境中进行研究，以发展研究管理、指导和授予写作技能 维持他们的研究事业。博士后这一职位在非洲学术界并不常见。 作为一家研究机构，BRTI将允许博士后研究员专注于培养领导技能， 实施和分析正在进行的项目。研究员将设计和管理他们自己的项目和 研究团队，解释数据，阐明并在导师和 在任期内完成研究资助的申请。 这种三管齐下的方法将有效地建立先进的卫生研究能力，填补以下方面的关键空白 津巴布韦目前的艾滋病毒研究。活动和培训的方向将是结合新的 以科学方法解决关键人群的公共卫生优先事项：儿童、青少年和青年 妇女，在社区环境中。评价战略将包括以下方面的形成和总结证据 活动和产出。结果评估将包括对学生和同事的评估 成就、介绍和出版物及其对政策和利益攸关方的影响。

ABSTRACT: Advanced training in Community Based HIV Research In Zimbabwe with one of the highest HIV burdens in the world, data and samples collected in community based research can contribute valuable information to improve prevention and care. Building new skills and capacity for molecular epidemiology and genomics focuses on the best use of these resources. Training in the interdisciplinary continuum of basic lab research skills, bioinformatics, modeling and data science for relevant, ethical research will address Zimbabwe's National and NIH/Fogarty goals. We propose a 3- pronged approach: To develop research skills: We will conduct short course training for students and post-graduates to develop the skills underpinning contemporary community based research, to design innovative studies integrating geolocation, epidemiologic and molecular research methods to interpret data on HIV transmission and prevention. We propose to introduce and promote the use of bioinformatics, to develop skills in phylogenetic, host and viral genetics that can be applied to address the ongoing epidemic. To promote research at doctoral level: We request support for 5 PhD students, from biologic, social science or medical disciplines. Students registered with universities in Zimbabwe will identify suitable projects and mentors to conduct HIV research relevant to Drug resistance, Genomics and Pathogenesis of HIV in community based studies. Support will include payment of fees and a modest stipend; academic supervision and mentoring from local and/or international experts will be compensated to ensure interdisciplinary scientific development and quality of postgraduate outcomes. To develop future research leadership. This can be achieved by supporting postdoctoral fellows to conduct research in a mentored environment to develop research management, mentoring and grant writing skills to sustain their research career. The position of “Postdoctoral Fellow” is uncommon in African academic circles. As a research institution, the BRTI will permit Postdoctoral fellows to focus on developing leadership skills, implementing and analyzing ongoing projects. Fellows will design and manage their own projects and research teams, interpret data, articulate and present findings to peers under the guidance of mentors and complete applications for a research grant during their tenure. This 3-pronged approach will effectively build advanced health research capacity filling critical gaps in current HIV research in Zimbabwe. The activities and training will be directed towards combining new scientific methods to address the public health priorities of key populations: children, adolescents and young women, in community settings. The evaluation strategies will include formative and summative evidence of activity and output. Outcome assessment will encompass through evaluations of student and fellow achievements, presentations and publications, and their impact on policy and stakeholders.