Mechanistic studies of a bifurcating flavoprotein
分叉黄素蛋白的机理研究
基本信息
- 批准号:10387414
- 负责人:
- 金额:$ 13.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:ComplexCoupledCryoelectron MicroscopyDefectDiseaseElectron TransportElectron transfer flavoproteinElectronsEnzymesEventFamilyFerredoxinFerredoxin-NAD+ reductaseFlavinsFlavoproteinsFunctional disorderGoalsHumanIronIron-Sulfur ProteinsKineticsMetabolismMitochondriaMolecularMotionNADHOxidantsPlayProcessPyrobaculumQuinonesReactionRoleSignal TransductionStructureSulfurSystemThermodynamicsVitamin K 2Workbasedeprotonationelectron donorenzyme modelfatty acid oxidationhuman diseasememberprotonationsemiquinone
项目摘要
Project Abstract
Electron-transferring flavoproteins (ETFs) are a large and broadly distributed family of
electron carriers that play critical roles in a variety of metabolic processes, including -oxidation of
fatty acids in humans. Defects in ETFs give rise to several specific disease states. A subset of the
ETF family constitute a recently discovered class of complex flavoproteins that catalyze the coupled
reduction of high- and low-potential electron acceptors using a median-potential electron donor in a
process referred to as electron bifurcation. An example of such a bifurcating ETF is the EtfABCX
system from Pyrobaculum aerophilum. This enzyme accepts reducing equivalents from NADH,
passing the reducing equivalents on to the high-potential menaquinone and the low-potential iron-
sulfur protein ferredoxin in a manner that is overall thermodynamically favorable. The proposed
work will examine in detail the kinetics of electron bifurcation as catalyzed by EtfABCX, critically
evaluating the involvement of protonation/deprotonation processes associated with the primary
electron transfer events.
项目摘要
电子转移黄素蛋白(ETF)是一个分布广泛的大家族。
电子载体在各种代谢过程中发挥关键作用,包括-氧化
人类体内的脂肪酸。ETF的缺陷会导致几种特定的疾病状态。属性的子集
ETF家族构成了最近发现的一类复杂的黄素蛋白,它催化偶联
用中电势电子给体减少高电势和低电势电子受体
称为电子分叉的过程。这种分叉ETF的一个例子是EtfABCX
从嗜氧性焦杆菌中分离的菌株。该酶接受来自NADH的还原当量,
将还原当量传递给高电势的孟喹酮和低电势的铁--
硫蛋白铁氧还蛋白以一种总体热力学上有利的方式。建议数
这项工作将详细研究由EtfABCX催化的电子分叉动力学,
评估与初级粒子相关的质子化/去质子化过程的参与
电子转移事件。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Russ Hille其他文献
Russ Hille的其他文献
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{{ truncateString('Russ Hille', 18)}}的其他基金
Mechanistic studies of a bifurcating flavoprotein
分叉黄素蛋白的机理研究
- 批准号:
10410411 - 财政年份:2020
- 资助金额:
$ 13.19万 - 项目类别:
Mechanistic studies of a bifurcating flavoprotein
分叉黄素蛋白的机理研究
- 批准号:
10640091 - 财政年份:2020
- 资助金额:
$ 13.19万 - 项目类别:
Mechanistic studies of a bifurcating flavoprotein
分叉黄素蛋白的机理研究
- 批准号:
10201670 - 财政年份:2020
- 资助金额:
$ 13.19万 - 项目类别:
Structure/activity studies of two molybdenum enzymes
两种钼酶的结构/活性研究
- 批准号:
7892110 - 财政年份:2009
- 资助金额:
$ 13.19万 - 项目类别:
Structure/activity studies of two molybdenum enzymes
两种钼酶的结构/活性研究
- 批准号:
7441263 - 财政年份:2005
- 资助金额:
$ 13.19万 - 项目类别:
Studies of environmentally relevant molybdenum enzymes
环境相关钼酶的研究
- 批准号:
7117987 - 财政年份:2005
- 资助金额:
$ 13.19万 - 项目类别:
Structure/activity studies of two molybdenum enzymes
两种钼酶的结构/活性研究
- 批准号:
6961309 - 财政年份:2005
- 资助金额:
$ 13.19万 - 项目类别:
Structure/activity studies of two molybdenum enzymes
两种钼酶的结构/活性研究
- 批准号:
7437368 - 财政年份:2005
- 资助金额:
$ 13.19万 - 项目类别:
Studies of environmentally relevant molybdenum enzymes
环境相关钼酶的研究
- 批准号:
7683053 - 财政年份:2005
- 资助金额:
$ 13.19万 - 项目类别:
Structure/activity studies of two molybdenum enzymes
两种钼酶的结构/活性研究
- 批准号:
7094249 - 财政年份:2005
- 资助金额:
$ 13.19万 - 项目类别:
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