Neural measures of temporal processing deficits affecting speech comprehension in listeners with normal hearing thresholds
时间处理缺陷的神经测量影响听力阈值正常的听众的言语理解
基本信息
- 批准号:10382033
- 负责人:
- 金额:$ 1.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2021-10-31
- 项目状态:已结题
- 来源:
- 关键词:Acoustic NerveAcousticsAdultAffectAnimal ExperimentationAnimal ModelAreaAttentionAttenuatedAuditoryAuditory PerceptionAuditory ThresholdBehavioralBrainCell physiologyCharacteristicsCochleaCodeCommunicationCommunication impairmentComprehensionConsensusCuesDiagnostic testsDiscriminationElectroencephalographyEnvironmentExhibitsExposure toFrequenciesGoalsGroupingHair CellsHumanImpairmentIndividualInvestigationKnowledgeLeadLinkMeasuresMechanicsMentorsMethodsNerve FibersNoiseParticipantPatternPerceptionPerformancePhasePhysiologicalPopulationProcessPsychophysicsQuality of lifeResearchScientistSignal TransductionSpeechSpeech SoundStimulusStreamSumSymptomsSynapsesTrainingVariantVoiceWorkWorkplaceattentional controlattentional modulationauditory processingauditory stimuluscareercochlear synaptopathycomprehension deficitexperienceexperimental studyhearing impairmentnoise perceptionnormal hearingnovelrelating to nervous systemresponsesegregationselective attentionsignal processingsocialsoundspeech in noisestandard measure
项目摘要
PROJECT SUMMARY/ABSTRACT
Some individuals with normal hearing thresholds (NHTs) demonstrate considerable challenges
perceiving speech in the presence of background noise. Evidence from recent studies suggests
that this impairment may be the result of cochlear synaptopathy (CS), degeneration of the
synapses between cochlear hair cells and the auditory nerve, observed in animal models following
exposure to high-intensity noise that does not permanently alter hearing thresholds. Still, it is not
known exactly how noise-induced CS would contribute to impairments in speech-in-noise
perception in humans with NHTs. CS engenders auditory nerve fiber degeneration and weakens
auditory nerve phase-locking to the precise timing information in auditory signals; therefore, the
goal of this research is to determine whether temporal processing impairments from noise-
induced CS are consistent with speech-in-noise perceptual deficits in listeners with NHTs. This
investigation will contrast listeners with high- and low-likelihood of noise-induced CS, as assessed
by a measure of summed auditory nerve fiber responses, on two mechanisms for segregating
speech streams that depend on accurate coding of precise timing information. Aim #1 of this
investigation will examine use of interaural timing difference cues for spatial attention to speech
streams and the degree to which attention to a target stream modulates cortical responses. Aim
#2 will utilize a novel task to assess participants’ ability to use pitch cues that can only be coded
by auditory nerve phase-locking to perceptually separate speech streams. Cortical entrainment
to the temporal envelope of speech, which has been shown to increase perceptual representation
of individual streams, will also be examined during this paradigm. Compared to participants with
a low likelihood of CS, it is expected that those with a high likelihood of having CS will perform
more poorly on tasks that require use of precise timing cues to segregate speech sounds from
competing streams. These listeners should also demonstrate lower cortical modulation and neural
synchrony to speech streams, demonstrating that bottom-up deficits in temporal encoding alter
neural representations of speech in the presence of competing sounds. These findings will
provide support for a link between noise-induced CS and impaired speech understanding in noise
in listeners with NHTs and will provide valuable knowledge of the contributors to this
communication impairment. This research will take place in an exceptional training environment
and the PI will be mentored by two knowledgeable, accomplished scientists. These experiments
will provide the PI with training in psychophysical task construction, brain activity recording, and
signal processing methods and will prepare her well for a career as an independent scientist.
项目总结/摘要
一些听力阈值正常的人表现出相当大的挑战
在存在背景噪声的情况下感知语音。最近的研究表明,
这种损害可能是耳蜗突触病(CS)的结果,
耳蜗毛细胞和听神经之间的突触,在动物模型中观察到,
暴露于不会永久改变听力阈值的高强度噪音。然而,
确切地知道噪声诱导的CS如何导致噪声中的语音损伤
NHT患者的感知能力CS引起听神经纤维变性,
听觉神经相位锁定听觉信号中的精确定时信息;因此,
这项研究的目的是确定是否时间处理损伤噪声-
诱发的CS与NHT患者的噪声中语音感知缺陷一致。这
调查将根据评估结果,对具有高和低噪声诱导CS可能性的听众进行对比
通过测量总的听觉神经纤维反应,在两种机制上分离
语音流依赖于精确定时信息的精确编码。目标#1
一项研究将检验两耳间时间差异线索对言语空间注意的作用
流和对目标流的注意调节皮层反应的程度。目的
#2将利用一个新的任务来评估参与者使用只能编码的音高提示的能力
通过听觉神经锁相来感知分离语音流。皮质卷吸
语音的时间包络,这已被证明可以增加感知表示
在此范例中,还将检查单个流。与参与者相比,
CS的可能性较低,预计那些具有CS高可能性的人将表现出
更差的任务,需要使用精确的时间线索,以分离语音声音,
竞争的溪流。这些听众还应该表现出较低的皮层调制和神经
同步的语音流,表明自下而上的赤字时间编码改变
在竞争性声音存在的情况下语言的神经表征。这些发现将
为噪声诱导的CS和噪声中言语理解受损之间的联系提供支持
在听众与NHT,并将提供有价值的知识的贡献者,
沟通障碍这项研究将在一个特殊的培训环境中进行
PI将由两位知识渊博的科学家指导。这些实验
将为PI提供心理物理任务构建、大脑活动记录和
信号处理方法,并将准备她作为一个独立的科学家的职业生涯。
项目成果
期刊论文数量(0)
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Mishaela T DiNino其他文献
Mishaela T DiNino的其他文献
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{{ truncateString('Mishaela T DiNino', 18)}}的其他基金
Neural measures of temporal processing deficits affecting speech comprehension in listeners with normal hearing thresholds
时间处理缺陷的神经测量影响听力阈值正常的听众的言语理解
- 批准号:
9909656 - 财政年份:2020
- 资助金额:
$ 1.66万 - 项目类别:
Neural measures of temporal processing deficits affecting speech comprehension in listeners with normal hearing thresholds
时间处理缺陷的神经测量影响听力阈值正常的听众的言语理解
- 批准号:
10020167 - 财政年份:2020
- 资助金额:
$ 1.66万 - 项目类别:
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