Factors Associated with Mailed Return of Self-Sampling for Human Papillomavirus (HPV) Testing

项目总结/摘要 宫颈癌对低收入和从未/未充分筛查（从未）的妇女的影响不成比例 筛选或筛选不足）。低收入妇女在以下方面存在结构性和内在障碍： 筛选，可能会阻止他们获得基于提供者的筛选。虽然HPV检测现在 被USPSTF指南接受，它只适用于供应商收集的样本。HPV自我采样 检测，一种妇女收集自己的宫颈阴道样本的方法，是一种可行和可接受的方法， 宫颈癌筛查的替代方案。HPV自我采样很可能作为一种 由于其对提供者收集的HPV样本的敏感性相当， 可接受性，以及接触从未/未充分筛查的人群的潜力。自我采样可以克服 低收入和低收入妇女在接受基于提供者的宫颈癌筛查方面遇到的障碍， 从不/筛选不足，并提供方便的方式来访问筛选。检测邮寄HPV试剂盒的研究， 然而，已经证明30 - 50%的妇女不返回邮寄的HPV试剂盒。此前， 实施，需要研究以确定邮寄HPV的携带者和非携带者的特征 自我采样工具包。这项描述性研究的目的是确定与邮寄退货相关的因素， HPV自采样试剂盒使用创新扩散理论的概念（优势，兼容性， 复杂性和自我效能），同时控制社会人口统计学、医疗保健和健康行为变量 在一群低收入和从未/筛选不足的妇女中。 这项横断面研究的数据将在研究同意时从女性（n = 200）中收集， 餐具室自我采样工具包将在同意后一周内邮寄到妇女家中，妇女将 有4个星期的时间来返回工具包被认为是"复制者"。收集的数据之间的关系 基线同意（创新的属性-优势、兼容性、复杂性和自我效能）和回报 将分析通过邮件（是/否）发送的自采样试剂盒。 本研究的结果将提供与自采样工具包返回相关因素的知识， 更好地了解非肥胖者和肥胖者的特点。该项目的成果将有助于指导 在低收入和从未/未充分筛查的人群中实施HPV自我采样， 采样可能最有可能受益。这项研究将为申请人的长期目标奠定基础， 通过提高宫颈癌筛查率，降低宫颈癌发病率和死亡率， 一项创新技术，用于HPV检测的自我采样。此外，这一申请反映了一项要求， NRSA个人研究员育儿费用行政补充金NOT-ON-21 - 070。

Project Summary/Abstract Cervical cancer disproportionately affects women who are low-income and never/underscreened (never screened or under screened). Women who are low-income have structural and intrapersonal barriers to screening that may prevent them from obtaining provider-based screening. Although HPV testing is now accepted by USPSTF guidelines, it is only endorsed for provider-collected sampling. Self-sampling for HPV testing, a method for women to collect their own cervico-vaginal sample, is a feasible and acceptable alternative to provider-based cervical cancer screening. HPV self-sampling is likely to be implemented as a screening option in the US in the future due to its comparable sensitivity to provider-collected HPV samples, acceptability, and potential to reach populations who are never/underscreeners. Self-sampling may overcome barriers to provider-based cervical cancer screening experienced by women who are low-income and never/underscreened and provide a convenient way to access screening. Studies testing mailed HPV kits, however, have demonstrated that 30-50% of women do not return a mailed HPV kit. Prior to widespread implementation, research is needed to identify characteristics of returners and non-returners of mailed HPV self-sampling kits. The purpose of this descriptive study is to identify factors associated with mailed return of HPV self-sampling kits using concepts from the Diffusion of Innovations Theory (advantages, compatibility, complexity, and self-efficacy) while controlling for sociodemographic, healthcare, and health behavior variables in a group of low-income and never/underscreened women. Data for this cross-sectional study will be collected at time of study consent from women (n=200) at a food pantry. Self-sampling kits will be mailed to the women’s home within one week of consent, and women will have 4 weeks to return the kit to be considered “returners”. The relationship between the data collected at baseline consent (attributes of innovation-advantages, compatibility, complexity, and self-efficacy) and return of the self-sampling kit via mail (y/n) will be analyzed. The results of this study will provide knowledge about factors associated with return of self-sampling kits to better understand the characteristics of returners and non-returners. Results of this project will help guide implementation of HPV self-sampling in populations who are low-income and never/underscreened whom self- sampling may most likely benefit. This study will provide a foundation for the applicant’s long-term goal of reducing morbidity and mortality from cervical cancer through increasing cervical cancer screening rates with an innovative technology, self-sampling for HPV testing. In addition, this application reflects a request for the Administrative Supplement for Childcare Costs for NRSA Individual Fellows NOT-ON-21-070.