Utilizing publicly available data to improve long-term quality of life following pediatric sepsis while fostering a new generation of sepsis investigators
利用公开数据改善儿科败血症后的长期生活质量,同时培养新一代败血症研究人员
基本信息
- 批准号:10385710
- 负责人:
- 金额:$ 7.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-06 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdmission activityAdolescentAffectAgeBehavioralBiometryCaregiversCaringCause of DeathCessation of lifeCharacteristicsChildChild CareChildhoodChronicClinicalClinical InvestigatorClinical ProtocolsClinical TrialsCognitiveCommunitiesDataData AnalysesData SetDatabasesDevelopmentEnrollmentEnvironmental Risk FactorEvaluationEvaluation StudiesFacultyFamilyFamily CaregiverFluid BalanceFosteringFoundationsFunctional disorderFundingGenerationsGoalsHospital MortalityHospitalizationImmune System DiseasesImpairmentIndividualInstitutionInterventionJournalsKnowledgeLeadershipLifeLongitudinal cohort studyManuscriptsMediatingMentorsMentorshipMissionMorbidity - disease rateNational Institute of Child Health and Human DevelopmentOrganOutcomeOutcomes ResearchPediatric HospitalsPediatric Intensive Care UnitsProspective cohort studyPublic HealthPublishingQuality of CareQuality of lifeResearchResearch PersonnelRiskSepsisSeptic ShockSeverity of illnessSurvivorsTestingUnited States National Institutes of Healthcare giving burdendesigndisabilityevidence baseexperiencefunctional statushealth related quality of lifeimprovedimproved outcomeinnovationmortalitypathogenpediatric sepsisphysically handicappedpreventprimary caregiverpsychological distress
项目摘要
PROJECT SUMMARY/ABSTRACT
Community-acquired septic shock is a major cause of death among children and often leads to poor long-term
health-related quality-of-life (HRQL) among survivors. Long-term HRQL following pediatric septic shock may be
affected by many baseline and clinical factors that have not yet been adequately investigated. The long-term
goal of this research is to improve outcomes from pediatric community-acquired septic shock. The overall
objective is to identify modifiable factors related to the clinical course of children with septic shock as well as pre-
existing child or environmental factors that may impact long-term morbidity and mortality. The central hypothesis
is that identifiable, modifiable factors during pediatric community-acquired septic shock may affect the risk of
long-term morbidity and mortality among children encountering septic shock, as well as the risk of family
dysfunction and psychological distress among their caregivers. The expected outcomes of the research are new
knowledge about factors contributing to adverse child and family outcomes following pediatric septic shock. This
new knowledge will have a positive impact because it will provide an evidence-base for the development and
testing of new interventions targeted at modifiable factors. The specific aims of this project are Aim 1) Identify
baseline characteristics that are associated with impaired long-term functional status and health-related quality
of life among children following community-acquired septic shock. Aim 2) Identify aspects of the clinical course
that are associated with impaired long-term functional status and health-related quality of life among children
following community-acquired septic shock. Aim 3) Identify factors associated with long-term family functioning
and psychological distress of the primary caregiver following their child’s hospitalization for community-acquired
septic shock. The approach to address these aims is to collaborate with junior investigators and their local
mentors from several academic institutions to answer important questions about pediatric sepsis using a publicly
available dataset from the NIH-funded Life After Pediatric Sepsis Evaluation (LAPSE) study. Junior investigators
will be provided with complete biostatistical support and additional mentorship from experts in pediatric sepsis
and the LAPSE study. This contribution is significant because it will provide an evidence basis for designing
definitive clinical trials and developing clinical protocols that address modifiable factors to optimizing care and
improving long-term child and family outcomes following septic shock. The research proposed is innovative
because it will result in a substantial departure from the status quo by introducing junior investigators to the
benefits of using established public use databases and providing them with an educational experience in their
use.
项目总结/文摘
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of Sex and Age with Mortality and Health-Related Quality of Life in Children with Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation.
感染性休克儿童的性别和年龄与死亡率和健康相关生活质量的关联:儿科脓毒症评估后生活的二次分析。
- DOI:10.1177/08850666231190270
- 发表时间:2023
- 期刊:
- 影响因子:3.1
- 作者:Prout,AndrewJ;Banks,RussellK;Reeder,RonW;Zimmerman,JerryJ;Meert,KathleenL
- 通讯作者:Meert,KathleenL
Change in Functional Status During Hospital Admission and Long-Term Health-Related Quality of Life Among Pediatric Septic Shock Survivors.
儿科感染性休克幸存者住院期间功能状态的变化以及与健康相关的长期生活质量。
- DOI:10.1097/pcc.0000000000003312
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Workman,JenniferK;Reeder,RonW;Banks,RussellK;Zimmerman,JerryJ;Meert,KathleenL;Keenan,HeatherT
- 通讯作者:Keenan,HeatherT
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Ron William Reeder其他文献
Ron William Reeder的其他文献
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