Utilizing publicly available data to improve long-term quality of life following pediatric sepsis while fostering a new generation of sepsis investigators

利用公开数据改善儿科败血症后的长期生活质量,同时培养新一代败血症研究人员

基本信息

  • 批准号:
    10385710
  • 负责人:
  • 金额:
    $ 7.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-06 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Community-acquired septic shock is a major cause of death among children and often leads to poor long-term health-related quality-of-life (HRQL) among survivors. Long-term HRQL following pediatric septic shock may be affected by many baseline and clinical factors that have not yet been adequately investigated. The long-term goal of this research is to improve outcomes from pediatric community-acquired septic shock. The overall objective is to identify modifiable factors related to the clinical course of children with septic shock as well as pre- existing child or environmental factors that may impact long-term morbidity and mortality. The central hypothesis is that identifiable, modifiable factors during pediatric community-acquired septic shock may affect the risk of long-term morbidity and mortality among children encountering septic shock, as well as the risk of family dysfunction and psychological distress among their caregivers. The expected outcomes of the research are new knowledge about factors contributing to adverse child and family outcomes following pediatric septic shock. This new knowledge will have a positive impact because it will provide an evidence-base for the development and testing of new interventions targeted at modifiable factors. The specific aims of this project are Aim 1) Identify baseline characteristics that are associated with impaired long-term functional status and health-related quality of life among children following community-acquired septic shock. Aim 2) Identify aspects of the clinical course that are associated with impaired long-term functional status and health-related quality of life among children following community-acquired septic shock. Aim 3) Identify factors associated with long-term family functioning and psychological distress of the primary caregiver following their child’s hospitalization for community-acquired septic shock. The approach to address these aims is to collaborate with junior investigators and their local mentors from several academic institutions to answer important questions about pediatric sepsis using a publicly available dataset from the NIH-funded Life After Pediatric Sepsis Evaluation (LAPSE) study. Junior investigators will be provided with complete biostatistical support and additional mentorship from experts in pediatric sepsis and the LAPSE study. This contribution is significant because it will provide an evidence basis for designing definitive clinical trials and developing clinical protocols that address modifiable factors to optimizing care and improving long-term child and family outcomes following septic shock. The research proposed is innovative because it will result in a substantial departure from the status quo by introducing junior investigators to the benefits of using established public use databases and providing them with an educational experience in their use.
项目总结/文摘

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of Sex and Age with Mortality and Health-Related Quality of Life in Children with Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation.
感染性休克儿童的性别和年龄与死亡率和健康相关生活质量的关联:儿科脓毒症评估后生活的二次分析。
  • DOI:
    10.1177/08850666231190270
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Prout,AndrewJ;Banks,RussellK;Reeder,RonW;Zimmerman,JerryJ;Meert,KathleenL
  • 通讯作者:
    Meert,KathleenL
Change in Functional Status During Hospital Admission and Long-Term Health-Related Quality of Life Among Pediatric Septic Shock Survivors.
儿科感染性休克幸存者住院期间功能状态的变化以及与健康相关的长期生活质量。
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Ron William Reeder其他文献

Ron William Reeder的其他文献

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