Einstein Aging Study

爱因斯坦衰老研究

• 批准号: 10391027
• 负责人: Richard B. LIPTON
• 金额: $ 66.09万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391027
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Autopsy; Behavioral; Biological; Biological Markers; Biological Process; Brain; Cessation of life; Characteristics; Clinic; Clinical; Clinical Research; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Communities; Consensus; County; Data; Dementia; Development; Dropout; Ecological momentary assessment; Elderly; Emotional; Ensure; Environmental Risk Factor; Family; Freezing; Frequencies; Funding; Funding Opportunities; Gifts; Goals; Grant; Health; Health Care Costs; Health Status; Health behavior; Impaired cognition; Independent Living; Individual; Infrastructure; International; Learning; Life; Link; Measurement; Measures; Medical; Metabolic; Methods; Mind; Nature; New York; Outcome; Pain; Participant; Pathology; Pathway interactions; Pattern; Performance; Persons; Phase; Physical Performance; Preventive measure; Psychosocial Factor; Public Health; Quality of life; Research; Research Personnel; Resources; Risk Assessment; Risk Factors; Role; Sleep; Specimen; Stress; Testing; Time; United States National Institutes of Health; Visit; Work; base; cognitive change; cognitive function; cognitive performance; cognitive testing; cohort; comorbidity; data quality; dementia risk; design; effective therapy; ethnic diversity; experience; follow-up; handheld mobile device; heart rate variability; human old age (65+); improved; innovation; mobile computing; modifiable risk; next generation; novel; outreach; pre-clinical; prevent; preventive intervention; programs; racial and ethnic; racial and ethnic disparities; racial diversity; recruit; response; sensor technology; social; social factors

Abstract The Einstein Aging Study (EAS) has long focused on the risk factors and cognitive changes that predict the subsequent onset of dementia, particularly Alzheimer’s dementia and related dementias (ADRD). The study is based on a community based cohort of older adults from Bronx County, NY. In the current funding period, we have developed novel intensive longitudinal methods to assess cognitive status and risk factors for ADRD using ecological momentary assessment (EMA) methods. These improve upon some limitations of single-shot clinic based assessments, providing measures of cognitive function in everyday life, enabling analyses of within person variability in cognitive function, and capturing data on exposures in “real-time” versus retrospective recall. The novel ambulatory measures are combined with robust clinic-based measures of cognitive performance, biomarkers, health status and health behaviors to identify early cognitive changes and decline and modifiable risk factors in the pre-clinical phase of ADRD. We have recently submitted a renewal P01 application for the EAS in response to the funding opportunity PAR- 19-314 (January 25, 2021) that will extend this work by utilizing mobile devices to capture the dynamic time-varying nature of risk factors and cognitive performance as participants engage in their usual daily activities in order to elucidate pathways linking behavioral, social/emotional and metabolic health, as well as environmental factors to early cognitive decline. Capitalizing on the increasing diversity of the EAS community, the project includes emphasis on examining social factors related to racial/ethnic disparities in cognitive health. In order to accomplish the P01s goals, it is important to keep intact the EAS established infrastructure (including valued staff who connect with participants and help with retention), continue the comprehensive characterization of the existing cohort, avoid gaps in ascertainment of outcomes and time varying exposures, maintain data quality, continue existing collaborations and obtain brains and perform autopsies for EAS participants in the ”Gift of Autopsy” program. The EAS has made significant contributions to cognitive aging research. Above and beyond contributions linked to project aims, the diverse, community-based cohort is recognized as a valuable resource that is used in numerous national and international collaborative projects. In this supplement, we request bridge funding to maintain high retention of the existing racially/ethnically diverse cohort and maintain the critically established infrastructure while the renewal application is under consideration. The current EAS funding period ends on May 31, 2021. If funded based on the January 25th submission, the start date would not begin until December 1, 2021. If necessary, the resubmission date in response to PAR- 19-314 would be in September, 2021, with a start date of June 1, 2021.

摘要 爱因斯坦老龄化研究(EAS)长期以来一直专注于预测老年人衰老的风险因素和认知变化 随后出现痴呆症，特别是阿尔茨海默氏症和相关痴呆(ADRD)。这项研究是 基于来自纽约州布朗克斯县的社区老年人队列。在当前的资助期内，我们 开发了新的密集纵向方法来评估ADRD的认知状态和风险因素 使用生态瞬时评估(EMA)方法。这些改进了单次放炮的一些限制 基于临床的评估，提供日常生活中认知功能的测量，使分析成为可能 在人内认知功能的变异性，并捕获关于暴露的实时数据与 追溯性回忆。新的门诊措施与强有力的基于临床的措施相结合 认知表现、生物标志物、健康状况和健康行为，以识别早期认知变化和 ADRD临床前阶段的下降和可修改的危险因素。 我们最近因应拨款机会，提交了P01续期申请。 PAR-19-314(2021年1月25日)，将通过利用移动设备捕获动态 风险因素和认知表现的时变性，因为参与者从事日常工作 活动，以阐明将行为、社会/情绪和代谢健康联系起来的途径，以及 环境因素对早期认知功能衰退的影响。利用东亚峰会社区日益多样化的优势， 该项目包括强调审查与认知健康方面的种族/族裔差异有关的社会因素。 为了实现P01的目标，重要的是保持EAS已建立的基础设施完好无损 (包括与参与者建立联系并帮助保留的有价值的员工)，继续全面 现有队列的特征，避免在确定结果和时变暴露方面的差距， 维护数据质量，继续现有协作，获取大脑并为EAS执行尸检 参加“尸检礼物”计划的人。 EAS在认知老化研究方面做出了重大贡献。贡献之外的贡献 与项目目标相联系，多样化的、基于社区的队列被认为是一种宝贵的资源，可以使用 参与了许多国家和国际合作项目。在本补充文件中，我们要求提供过渡性资金 保持现有种族/族裔多元化群体的高度保留率，并保持关键的 在考虑续签申请期间建立基础设施。目前的EAS资金 期限将于2021年5月31日结束。如果根据1月25日提交的申请提供资金，开始日期将不会开始 直到2021年12月1日。如有必要，回复PAR-19-314的重新提交日期将在 2021年9月，开始日期为2021年6月1日。