Functional causality in regulating cell morphogenesis
Functional causality in regulating cell morphogenesis
批准号:
10387909
负责人:
Gaudenz Danuser
金额:
$20.0万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-05-01 至 2025-04-30
中文摘要
摘要
我们请求20万美元的资金和15万美元的机构成本分摊捐款来组装一个
用于3D成像的高光谱轴向扫描光片显微镜。该仪器将量身定做,以适应
两个新实验的要求,这两个实验应生成用于分析检查的高分辨率图像数据
形态发生信号通路与细胞形态调控之间的因果关系。显微镜会
以极低的速度支持最多7个不同光谱通道的高灵敏度、准同步图像采集
在XYZ的空间分辨率为300纳米,以及秒尺度的时间分辨率。
英文摘要
ABSTRACT
We request funds of $200K with an institutional cost sharing contribution of $150K to assemble a
hyperspectral axially swept light sheet microscope for 3D imaging. The instrument will be tailored to the
requirements of two new experiments that should generate high-resolution image data for analytical scrutiny of
the causal relations between morphogenic signaling pathways and cell shape modulation. The microscope will
support highly sensitive, quasi-simultaneous image acquisition of up to 7 spectrally distinct channels at very low
light exposure and at a spatial resolution of 300 nm in XYZ and second scale temporal resolution.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
UTSW-UNC Center for Cell Signaling Analysis
-
批准号:10412148
-
项目类别:
-
资助金额:$160.71万
-
财政年份:2022
-
负责人:Gaudenz Danuser
-
依托单位:
UTSW-UNC Center for Cell Signaling Analysis
-
批准号:10705616
-
项目类别:
-
资助金额:$107.41万
-
财政年份:2022
-
负责人:Gaudenz Danuser
-
依托单位:
Administration and Coordination Core
-
批准号:10374649
-
项目类别:
-
资助金额:$33.77万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
-
批准号:10221568
-
项目类别:
-
资助金额:$54.12万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
-
批准号:10379219
-
项目类别:
-
资助金额:$51.49万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Imaging mechanisms of metastatic tumor formation in situ
-
批准号:10374648
-
项目类别:
-
资助金额:$168.85万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Administration and Coordination Core
-
批准号:10684858
-
项目类别:
-
资助金额:$15.08万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
-
批准号:10612345
-
项目类别:
-
资助金额:$51.49万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Imaging mechanisms of metastatic tumor formation in situ
-
批准号:10684857
-
项目类别:
-
资助金额:$153.65万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Administration and Coordination Core
-
批准号:10491346
-
项目类别:
-
资助金额:$15.76万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Imaging mechanisms of metastatic tumor formation in situ
-
批准号:10491345
-
项目类别:
-
资助金额:$160.93万
-
财政年份:2021
-
负责人:Gaudenz Danuser
-
依托单位:
Functional causality in regulating cell morphogenesis
-
批准号:10401805
-
项目类别:
-
资助金额:$85.9万
-
财政年份:2020
-
负责人:Gaudenz Danuser
-
依托单位:
Functional causality in regulating cell morphogenesis
-
批准号:10165091
-
项目类别:
-
资助金额:$18.83万
-
财政年份:2020
-
负责人:Gaudenz Danuser
-
依托单位:
Functional causality in regulating cell morphogenesis
-
批准号:10608127
-
项目类别:
-
资助金额:$92.37万
-
财政年份:2020
-
负责人:Gaudenz Danuser
-
依托单位:
Computational Image Analysis for Cellular and Developmental Biology
-
批准号:8414506
-
项目类别:
-
资助金额:$5.94万
-
财政年份:2013
-
负责人:Gaudenz Danuser
-
依托单位:
Computational Image Analysis for Cellular and Developmental Biology
-
批准号:8628140
-
项目类别:
-
资助金额:$5.94万
-
财政年份:2013
-
负责人:Gaudenz Danuser
-
依托单位:
Computational Image Analysis for Cellular and Developmental Biology
-
批准号:9215686
-
项目类别:
-
资助金额:$5.94万
-
财政年份:2013
-
负责人:Gaudenz Danuser
-
依托单位:
Project 3: Mechanical and molecular states of adhesions
-
批准号:8234228
-
项目类别:
-
资助金额:$21.03万
-
财政年份:2011
-
负责人:Gaudenz Danuser
-
依托单位:
Quantitative live cell imaging of vimentin network assembly and regulation
-
批准号:8142484
-
项目类别:
-
资助金额:$30.43万
-
财政年份:2011
-
负责人:Gaudenz Danuser
-
依托单位:
Quantitative live cell imaging of vimentin network assembly and regulation
-
批准号:10227015
-
项目类别:
-
资助金额:$26.02万
-
财政年份:2011
-
负责人:Gaudenz Danuser
-
依托单位:
海外基金