Improvements to the Regional Biocontainment Research Facilities at the University of Missouri
密苏里大学区域生物防护研究设施的改进
基本信息
- 批准号:10394455
- 负责人:
- 金额:$ 332.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-23 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AirAnimalsAreaArthropodsCarbon DioxideCommunicationContainmentContractorDecontaminationElevatorEquipmentGasesHydrogen PeroxideImmunologyInformation TechnologyLiquid substanceMaintenanceMechanicsMissouriModernizationNitrogenPhilosophySafetySecuritySeriesSteamSystemUniversitiesVacuumWalkingcostimprovedrepairedresearch facility
项目摘要
PROJECT SUMMARY/ABSTRACT
The central philosophy we used in approaching this opportunity was to not include items of routine
maintenance or repair, which are currently provided by our experts in facilities management. Instead, we
have focused on subsystem repairs or upgrades that are considered “betterments”. Betterments are not
routinely performed by facility management without an associated cost or without going through an external
contractor. Therefore, the scope of our proposal is limited to facility betterments. Broadly, the betterments
(or what we need) are divided into three major subareas as listed below while additional technical details
are provided in the Modernization Plan. We have identified a series of high priority targets and each request
is detailed within the following sections.
SPACES: REMODELING OF ARTHROPOD CONTAINMENT SUITE, ANIMAL ROOMS, CHANGE ROOMS AND
ROOF SYSTEM. Renovations of our change room spaces, replacement of the flat room section above our
security office and breakroom, painting and drywall repairs in our mechanical spaces, upgrades of our
ABSL3 space with Arcoplast ceilings and renovations to our arthropod containment suite.
FACILITY SUBSYSTEM UPGRADES/BETTERMENTS. Briefly, these subsystems include the following: an
elevator, upgrades to our outer fence and gates, security server and camera upgrades, upgrades to our
Phoenix valves and Metasys controllers, upgrades to our steam boiler burner systems, gas system upgrades
including liquid nitrogen, CO2, house vacuum and compressed air subsystems, and addition of a new suite
communication system.
REPLACEMENT/BETTERMENT OF CORE EQUIPMENT. To support the functionality and safety of the
improved facility we have requested and identified several pieces of equipment. Requested equipment
includes a new effluent decontamination system (EDS), 4 class II biosafety cabinets; 2 vaporous hydrogen
peroxide area decontamination systems; upgrades/replacements for the Immunology Core and Aerobiology
Core; information technology core improvements; and 2 walk-in arthropod environmental chambers.
项目摘要/摘要
我们利用这一机会的中心哲学是不包括例行项目
维护或维修,目前由我们的设施管理专家提供。而是
重点放在被视为“改善”的子系统维修或升级上。改善不是
由设施管理层定期执行,无需相关成本或通过外部
承包商因此,我们建议的范围只限于设施改善。概括地说,
(or我们所需要的)分为三个主要的子区域,如下所列,而其他技术细节
在现代化计划中。我们确定了一系列高优先级目标,
在以下各节中详细介绍。
空间:节肢动物收容室、动物室、更衣室和
屋顶系统。翻新我们的更衣室空间,更换我们上面的平面房间部分,
安全办公室和休息室,油漆和干墙维修我们的机械空间,升级我们的
ABSL 3空间与Arcoplast天花板和装修我们的节肢动物遏制套房。
FACEBOOK子系统升级/改进。简而言之,这些子系统包括:
电梯,升级我们的外部围栏和大门,安全服务器和摄像头升级,升级我们的
Phoenix阀门和Metasys控制器,蒸汽锅炉燃烧器系统升级,燃气系统升级
包括液氮、CO2、室内真空和压缩空气子系统,并增加了一个新的套件
通信系统
更换/改善核心设备。为了支持
我们要求改进设施,并确定了几件设备。所需设备
包括一个新的污水净化系统(EDS),4个二级生物安全柜,2个气态氢
过氧化氢区域净化系统;免疫学核心和空气生物学的升级/更换
核心;信息技术核心改进;和2个步入式节肢动物环境室。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christian L. Lorson其他文献
253. AAV Delivery of a Trans-Splicing RNA Re-Directs SMN2 Splicing and Results in Increased Full-Length SMN
- DOI:
10.1016/j.ymthe.2006.08.280 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:
- 作者:
Tristan H. Coady;Monir Shababi;Christian L. Lorson - 通讯作者:
Christian L. Lorson
415. Stimulating Full-Length SMN2 Expression by Delivering Bi-Functional RNAs Via a Viral Vector
- DOI:
10.1016/j.ymthe.2006.08.479 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:
- 作者:
Travis D. Baughan;Monir Shababi;Gregory E. Tullis;Christian L. Lorson - 通讯作者:
Christian L. Lorson
<em>Ighmbp2</em> mutations and disease pathology: Defining differences that differentiate SMARD1 and CMT2S
- DOI:
10.1016/j.expneurol.2024.115025 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Sara M. Ricardez Hernandez;Bassil Ahmed;Yaser Al Rawi;F. Javier Llorente Torres;Mona O. Garro Kacher;Catherine L. Smith;Zayd Al Rawi;Jessica Garcia;Nicole L. Nichols;Christian L. Lorson;Monique A. Lorson - 通讯作者:
Monique A. Lorson
Christian L. Lorson的其他文献
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{{ truncateString('Christian L. Lorson', 18)}}的其他基金
Improvements to the Regional Biocontainment Research Facilities at the University of Missouri
密苏里大学区域生物防护研究设施的改进
- 批准号:
10631453 - 财政年份:2021
- 资助金额:
$ 332.73万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
10558457 - 财政年份:2020
- 资助金额:
$ 332.73万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
10333249 - 财政年份:2020
- 资助金额:
$ 332.73万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
10087982 - 财政年份:2020
- 资助金额:
$ 332.73万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
9973984 - 财政年份:2020
- 资助金额:
$ 332.73万 - 项目类别:
Evaluating AAV-mediated gene replacement for Spinal Muscular Atrophy with Respiratory Distress 1
评估 AAV 介导的基因替换对伴有呼吸窘迫的脊髓性肌萎缩症 1
- 批准号:
9034843 - 财政年份:2015
- 资助金额:
$ 332.73万 - 项目类别:
Monoallelic repair of expanded huntingtin by trans-splicing
通过反式剪接对扩展的亨廷顿蛋白进行单等位基因修复
- 批准号:
8129437 - 财政年份:2010
- 资助金额:
$ 332.73万 - 项目类别:
Monoallelic repair of expanded huntingtin by trans-splicing
通过反式剪接对扩展的亨廷顿蛋白进行单等位基因修复
- 批准号:
8048355 - 财政年份:2010
- 资助金额:
$ 332.73万 - 项目类别:
Funding for FightSMA Researchers' Conference in Washington, DC, April 2008
为 2008 年 4 月在华盛顿特区举行的 FightSMA 研究人员会议提供资金
- 批准号:
7487724 - 财政年份:2008
- 资助金额:
$ 332.73万 - 项目类别:
Stimulating SMN2 exon 7 inclusion with short RNAs
用短 RNA 刺激 SMN2 外显子 7 包含
- 批准号:
7945390 - 财政年份:2007
- 资助金额:
$ 332.73万 - 项目类别:
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