Improvements to the Regional Biocontainment Research Facilities at the University of Missouri
密苏里大学区域生物防护研究设施的改进
基本信息
- 批准号:10631453
- 负责人:
- 金额:$ 234.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-23 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAerosolsAnimal ExperimentationAnimalsCommunitiesContainmentContractsDecontaminationEmerging Communicable DiseasesEquipmentFacultyFamily suidaeFundingGoalsGrantHepatitis B VirusHousingHumanInfectionInfectious Diseases ResearchLaboratoriesMissouriNational Institute of Allergy and Infectious DiseaseParentsPrincipal InvestigatorResearchResearch PersonnelRodentSecureServicesStudentsSystemTranslational ResearchUnited States National Institutes of HealthUniversitiesbiocontainment facilitybiodefensehuman pathogeninfluenzaviruspathogenic virusresearch facilityrespiratory viruswhole animal imaging
项目摘要
The objective of the parent G20 grant is to provide state of the art, highly safe and secure
biocontainment facilities and services to faculty, student and staff researchers at the MU Laboratory for
Infectious Diseases, one of 12 NIH/NIAID Regional Biocontainment Laboratories. The LIDR/MURBL is
currently host to more than 60 researchers. Our research community is successful in grant funding with 14
Principal Investigators currently active in federally and privately funded grants/contracts. The current ABSL3
facility supports aerosol challenge of rodents, but larger animal challenges cannot occur due to a lack of
appropriate containment housing. The goal of this G20 supplement project is to expand the capabilities of
the MURBL to serve the biodefense and emerging infectious disease research for the region. Towards this
objective, we propose to renovate the east suite of the ABSL3, including the installation of a specialized
ante room and effluent decontamination system, to allow for the housing of large animals in biocontainment.
These upgrades would serve the immediate needs of MU faculty of the RBL who are conducting
translational research on SARS-CoV-2, influenza virus, and hepatitis B virus.
Aim 1: Add open caging capabilities to the ABSL3 at LIDR for housing swine and other large animals
following challenge with respiratory viruses that are pathogenic to humans. We propose to build open
caging capacity in the ABSL3 at LIDR for housing up to 10 pigs or other large animals that have been
experimentally infected with various human pathogens. The request includes funds for remodeling in the
anteroom as well as the animal holding room/building effluent system to permit effluent decontamination, and
necessary HVAC upgrades.
Aim 2: Purchase and install equipment for whole animal imaging following infection. We propose to add
capabilities for whole animal imaging, which will allow for reduction of research animals used at LIDR.
G20母公司赠款的目标是提供最先进的、高度安全和可靠的
为墨尔本大学实验室的教职员工、学生和教职员工提供生物遏制设施和服务
传染病,NIH/NIAID的12个区域生物遏制实验室之一。LIDR/MURBL是
目前接待了60多名研究人员。我们的研究界成功地获得了14笔赠款资金
首席调查员目前活跃在联邦和私人资助的赠款/合同中。当前的ABSL3
设施支持啮齿动物的气溶胶挑战,但由于缺乏更大的动物挑战
适当的安全壳。这一G20补充项目的目标是扩大
MURBL将为该地区的生物防御和新发传染病研究服务。朝向这个方向
目标,我们建议翻新ABSL3的东侧套间,包括安装一个专门的
前室和污水净化系统,以允许大型动物在生物围栏中的住房。
这些升级将满足RBL的MU教员的迫切需求,他们正在进行
SARS-CoV-2、流感病毒和乙肝病毒的翻译研究。
目标1:在LIDR的ABSL3基础上增加开放式笼子能力,用于饲养猪和其他大型动物
在受到对人类具有致病性的呼吸道病毒的挑战之后。我们建议建立开放的
利德尔ABSL3的笼养能力可容纳多达10头猪或其他大型动物,这些猪或其他大型动物已经
实验感染了各种人类病原体。这项请求包括在
前厅和动物休息室/建筑物污水系统,以进行污水净化;以及
必要的暖通空调升级。
目的2:购买和安装感染后的全动物成像设备。我们建议增加
整个动物成像能力,这将允许减少LIDR使用的研究动物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christian L. Lorson其他文献
253. AAV Delivery of a Trans-Splicing RNA Re-Directs SMN2 Splicing and Results in Increased Full-Length SMN
- DOI:
10.1016/j.ymthe.2006.08.280 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:
- 作者:
Tristan H. Coady;Monir Shababi;Christian L. Lorson - 通讯作者:
Christian L. Lorson
415. Stimulating Full-Length SMN2 Expression by Delivering Bi-Functional RNAs Via a Viral Vector
- DOI:
10.1016/j.ymthe.2006.08.479 - 发表时间:
2006-01-01 - 期刊:
- 影响因子:
- 作者:
Travis D. Baughan;Monir Shababi;Gregory E. Tullis;Christian L. Lorson - 通讯作者:
Christian L. Lorson
<em>Ighmbp2</em> mutations and disease pathology: Defining differences that differentiate SMARD1 and CMT2S
- DOI:
10.1016/j.expneurol.2024.115025 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Sara M. Ricardez Hernandez;Bassil Ahmed;Yaser Al Rawi;F. Javier Llorente Torres;Mona O. Garro Kacher;Catherine L. Smith;Zayd Al Rawi;Jessica Garcia;Nicole L. Nichols;Christian L. Lorson;Monique A. Lorson - 通讯作者:
Monique A. Lorson
Christian L. Lorson的其他文献
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{{ truncateString('Christian L. Lorson', 18)}}的其他基金
Improvements to the Regional Biocontainment Research Facilities at the University of Missouri
密苏里大学区域生物防护研究设施的改进
- 批准号:
10394455 - 财政年份:2021
- 资助金额:
$ 234.07万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
10558457 - 财政年份:2020
- 资助金额:
$ 234.07万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
10333249 - 财政年份:2020
- 资助金额:
$ 234.07万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
10087982 - 财政年份:2020
- 资助金额:
$ 234.07万 - 项目类别:
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets
新型 SMARD1 小鼠模型:潜在治疗靶点的表征和评估
- 批准号:
9973984 - 财政年份:2020
- 资助金额:
$ 234.07万 - 项目类别:
Evaluating AAV-mediated gene replacement for Spinal Muscular Atrophy with Respiratory Distress 1
评估 AAV 介导的基因替换对伴有呼吸窘迫的脊髓性肌萎缩症 1
- 批准号:
9034843 - 财政年份:2015
- 资助金额:
$ 234.07万 - 项目类别:
Monoallelic repair of expanded huntingtin by trans-splicing
通过反式剪接对扩展的亨廷顿蛋白进行单等位基因修复
- 批准号:
8048355 - 财政年份:2010
- 资助金额:
$ 234.07万 - 项目类别:
Monoallelic repair of expanded huntingtin by trans-splicing
通过反式剪接对扩展的亨廷顿蛋白进行单等位基因修复
- 批准号:
8129437 - 财政年份:2010
- 资助金额:
$ 234.07万 - 项目类别:
Funding for FightSMA Researchers' Conference in Washington, DC, April 2008
为 2008 年 4 月在华盛顿特区举行的 FightSMA 研究人员会议提供资金
- 批准号:
7487724 - 财政年份:2008
- 资助金额:
$ 234.07万 - 项目类别:
Stimulating SMN2 exon 7 inclusion with short RNAs
用短 RNA 刺激 SMN2 外显子 7 包含
- 批准号:
7945390 - 财政年份:2007
- 资助金额:
$ 234.07万 - 项目类别:
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