Improvements to the Regional Biocontainment Research Facilities at the University of Missouri

密苏里大学区域生物防护研究设施的改进

• 批准号: 10631453
• 负责人: Christian L. Lorson
• 金额: $ 234.07万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631453
• 关键词: 2019-nCoV; Aerosols; Animal Experimentation; Animals; Communities; Containment; Contracts; Decontamination; Emerging Communicable Diseases; Equipment; Faculty; Family suidae; Funding; Goals; Grant; Hepatitis B Virus; Housing; Human; Infection; Infectious Diseases Research; Laboratories; Missouri; National Institute of Allergy and Infectious Disease; Parents; Principal Investigator; Research; Research Personnel; Rodent; Secure; Services; Students; System; Translational Research; United States National Institutes of Health; Universities; biocontainment facility; biodefense; human pathogen; influenzavirus; pathogenic virus; research facility; respiratory virus; whole animal imaging

The objective of the parent G20 grant is to provide state of the art, highly safe and secure biocontainment facilities and services to faculty, student and staff researchers at the MU Laboratory for Infectious Diseases, one of 12 NIH/NIAID Regional Biocontainment Laboratories. The LIDR/MURBL is currently host to more than 60 researchers. Our research community is successful in grant funding with 14 Principal Investigators currently active in federally and privately funded grants/contracts. The current ABSL3 facility supports aerosol challenge of rodents, but larger animal challenges cannot occur due to a lack of appropriate containment housing. The goal of this G20 supplement project is to expand the capabilities of the MURBL to serve the biodefense and emerging infectious disease research for the region. Towards this objective, we propose to renovate the east suite of the ABSL3, including the installation of a specialized ante room and effluent decontamination system, to allow for the housing of large animals in biocontainment. These upgrades would serve the immediate needs of MU faculty of the RBL who are conducting translational research on SARS-CoV-2, influenza virus, and hepatitis B virus. Aim 1: Add open caging capabilities to the ABSL3 at LIDR for housing swine and other large animals following challenge with respiratory viruses that are pathogenic to humans. We propose to build open caging capacity in the ABSL3 at LIDR for housing up to 10 pigs or other large animals that have been experimentally infected with various human pathogens. The request includes funds for remodeling in the anteroom as well as the animal holding room/building effluent system to permit effluent decontamination, and necessary HVAC upgrades. Aim 2: Purchase and install equipment for whole animal imaging following infection. We propose to add capabilities for whole animal imaging, which will allow for reduction of research animals used at LIDR.

G20母公司赠款的目标是提供最先进的、高度安全和可靠的 为墨尔本大学实验室的教职员工、学生和教职员工提供生物遏制设施和服务 传染病，NIH/NIAID的12个区域生物遏制实验室之一。LIDR/MURBL是 目前接待了60多名研究人员。我们的研究界成功地获得了14笔赠款资金 首席调查员目前活跃在联邦和私人资助的赠款/合同中。当前的ABSL3 设施支持啮齿动物的气溶胶挑战，但由于缺乏更大的动物挑战 适当的安全壳。这一G20补充项目的目标是扩大 MURBL将为该地区的生物防御和新发传染病研究服务。朝向这个方向 目标，我们建议翻新ABSL3的东侧套间，包括安装一个专门的 前室和污水净化系统，以允许大型动物在生物围栏中的住房。 这些升级将满足RBL的MU教员的迫切需求，他们正在进行 SARS-CoV-2、流感病毒和乙肝病毒的翻译研究。 目标1：在LIDR的ABSL3基础上增加开放式笼子能力，用于饲养猪和其他大型动物 在受到对人类具有致病性的呼吸道病毒的挑战之后。我们建议建立开放的 利德尔ABSL3的笼养能力可容纳多达10头猪或其他大型动物，这些猪或其他大型动物已经 实验感染了各种人类病原体。这项请求包括在 前厅和动物休息室/建筑物污水系统，以进行污水净化；以及 必要的暖通空调升级。 目的2：购买和安装感染后的全动物成像设备。我们建议增加 整个动物成像能力，这将允许减少LIDR使用的研究动物。