Facility and Building System Upgrades Support for the Howard T. Ricketts Biocontainment Laboratory

项目总结/摘要 霍华德泰勒里基茨实验室（HTRL）是一个国家的最先进的区域生物遏制 实验室在阿贡国家实验室（ANL）校园杜佩奇县，伊利诺伊州。 ANL位于芝加哥大学校园西南25英里处，是一个联邦政府机构， （能源部）拥有的网站由芝加哥大学（UCHICAGO LLC）运营。 HTRL是由芝加哥大学拥有的CDC认证设施，由 微生物学系。生物安全培训和监测方案，包括课堂 和实验室活动，确保工作人员，学生和研究员遵守国家和联邦 使用RG 2、RG 3和Select Agent安全操作设施和实验的法规 病原体HTRL建设于2008年完成。在过去的13年里，HTRL 主持了研究耶尔森氏菌、布鲁氏菌、柯克斯氏菌 立克次体、杆菌、MRSA和其他ESKAPE微生物，以及病毒病原体，包括 低致病性和高致病性流感、登革热和最近的SARS冠状病毒2。该设施 目前主持鼠疫，炭疽和MRSA的研究计划，以及核心研究 SARS-CoV 2的设施。HTRL是该地区最大的A-BSL 3持有设施， 定期支持联盟机构的研究，包括UIC，西北大学和 洛约拉大学HTRL正在实现其作为生物医学研究设施的目标， 响应研究需求，支持新兴和重新崛起的生物医学研究 病原体、新疗法和疫苗的发现和测试。该建筑已 保持良好的工作条件，并一直在不断使用，因为它的建设。 然而，随着对BSL 3和ABSL 3空间和研究专业知识的需求不断增加， 为研究传染性病原体开发新技术，本提案是一项要求（i） 为了升级维持生物防护所必需的系统组件， 温度/湿度/加压要求和安全研究操作，以及（ii） 更换已经超过预期使用寿命或不再符合要求的研究设备 设施要求。

Project Summary/Abstract The Howard Taylor Ricketts Laboratory (HTRL) is a state-of-the-art Regional Biocontainment Laboratory on the Argonne National Laboratory (ANL) campus in DuPage County, Illinois. Located twenty-five miles southwest from the University of Chicago campus, ANL is a federally (Department of Energy) owned site operated by the University of Chicago (UCHICAGO LLC). HTRL is a CDC certified facility owned by the University of Chicago and operated by the Department of Microbiology. Biosafety training and surveillance program involving classroom and laboratory activities ensures that staff, students and fellows comply with state and federal regulations to safely operate facilities and experiments with RG2, RG3 and Select Agent pathogens. The HTRL construction was completed in 2008. Over the last 13 years, the HTRL has hosted research programs studying the bacterial species Yersinia, Brucella, Coxiella, Rickettsia, Bacilli, MRSA and other ESKAPE organisms, as well as viral pathogens including low and highly pathogenic influenza, DENGUE and more recently SARS-CoV2. The facility currently hosts research program on Plague, Anthrax and MRSA, as well as a Core Research Facility for SARS-CoV2. The HTRL is the largest A-BSL3 holding facility in the region and regularly supports research from consortium institutions including UIC, Northwestern U and Loyola U. The HTRL is fulfilling its goal as a biomedical research facility that can rapidly respond to research needs and support biomedical research on emerging and re-emerging pathogens, discovery and testing of new therapeutics and vaccines. The building has been maintained in excellent working conditions and has been in constant use since its construction. However, with the swelling demands for BSL3 and ABSL3 space and research expertise, the development of new technologies for the study of infectious agents, this proposal is a request (i) to upgrade system components necessary to maintain biocontainment, temperature/humidity/pressurization requirements, and safe research operations, and (ii) to replace research equipment that have either outlived the intended useful life or no longer meet facility requirements.