Data-driven drug discovery: investigating the molecular mechanisms of safety and efficacy
Data-driven drug discovery: investigating the molecular mechanisms of safety and efficacy
批准号:
10393864
负责人:
Nicholas P Tatonetti
金额:
$1.33万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-05-01 至 2024-04-30
关键词:
Adverse drug eventAdverse effectsAdverse eventAffectAreaAwardBiochemicalComputer AnalysisComputing MethodologiesDataDatabasesDevelopmentDrug InteractionsDrug usageFundingGenetic VariationMetabolismMolecularParentsParticipantPharmaceutical PreparationsPharmacologyPhysiological Effects of DrugsProteinsResearchResearch Project GrantsSafetyVariantWorkdrug developmentdrug discoverygenetic variantinsightinterestlaboratory experimentlarge datasetspharmacovigilanceprograms
中文摘要
总结
英文摘要
Summary
Up to 30% of adverse drug events can be attributed to drug-drug interactions in metabolism or mechanism of
action. The study of drug-drug-protein interactions that drive these adverse effects, however, remains an
underexplored area of research. This research project aims to offer one of the first comprehensive insights into
the effect of genetic variants on adverse drug events, with a particular focus on drug-drug interactions. Through
the utilization of large datasets and computational methods, we aim to develop a data-driven approach to identify
genetic variations of target protein and metabolizing proteins associated with the development of adverse drug
events. Expanding from our current work, we will identify genetic variants affecting the proteins of interest,
participants in the study who have experienced the adverse drug events following use of the drugs and conduct
association studies to identify any significant variants.
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Data-driven drug discovery: investigating the molecular mechanisms of safety and efficacy
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批准号:9920189
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项目类别:
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资助金额:$48.11万
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财政年份:2019
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负责人:Nicholas P Tatonetti
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依托单位:
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资助金额:$19.55万
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批准号:10433846
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资助金额:$24.72万
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批准号:10625365
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资助金额:$35.36万
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负责人:Nicholas P Tatonetti
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批准号:8901230
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资助金额:$48.46万
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财政年份:2014
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负责人:Nicholas P Tatonetti
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依托单位:
Drug Effect Discovery Through Data Mining and Integrative Chemical Biology
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批准号:8696226
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资助金额:$59.75万
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财政年份:2014
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负责人:Nicholas P Tatonetti
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依托单位:
Drug Effect Discovery Through Data Mining and Integrative Chemical Biology
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批准号:9282587
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资助金额:$48.46万
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负责人:Nicholas P Tatonetti
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依托单位:
海外基金