Innovation Fund Application to the Multicenter AIDS Cohort Study MACS/Women's Interagency HIV Study WIHS Combined Cohort Study-MWCCS: COVID-19 Vaccine Acceptance and Hesitancy (CVHB) Study in People w

项目总结 就感染艾滋病毒而言，MWCCS参与者是严重新冠肺炎疾病的高危人群， 主要是老年人，并有许多潜在的合并症。因此，当务之急 他们希望自己能接种新冠肺炎疫苗。然而，到目前为止，只有轶事 有关艾滋病病毒感染者(PWH)对新冠肺炎疫苗接受度和疗效的数据。MWCCS非常适合 分析(A)新冠肺炎疫苗(S)在男女特发性肝炎和配型HIV感染者中的接受性和效果 未感染对照(HUC)，(B)年龄和合并症对疫苗免疫反应的影响以及 对新冠肺炎的保护，以及(C)新冠肺炎之后的社会、经济和行为变化 免疫接种与不接种疫苗的个人相比。为了解决这个问题，我们将有 两组MWCCS参与者：A组：男性和女性PWH和Huc，他们选择接受 新冠肺炎疫苗，B组：选择不接种新冠肺炎的男性和女性威尔斯亲王和胡克 疫苗。我们建议的纵向观察研究的目的是：目标1：进行混合方法 新冠肺炎疫苗迟迟不接种的流行率、相关性和细微差别的调查 MWCCS参与者。结果将有助于了解威尔斯亲王医院和中心人群对以下问题的关注 新冠肺炎疫苗基于年龄、性别、种族/民族和潜在的合并症负担。目标2：实现 测定威尔斯亲王医院新冠肺炎免疫后自然感染SARS-CoV-2的比较 对相同年龄、性别和民族/种族的HUC进行调查，并与非 接种疫苗的人。我们将限制目标2在基线上只获得一个样本，就在之前 A组接种疫苗，B组在可比时间段内接种疫苗。随后采集样本 在核心MWCCS期间，将在血清学分析中使用访问。这些样品将使我们能够 S免疫前和免疫后血清新冠肺炎状态检测 和N蛋白。免疫后抗S抗体滴定将提示疫苗免疫应答， 而抗N抗体滴度将表明SARS-CoV-2自然感染。此信息将允许 疫苗接种后和接种后感染SARS-CoV-2无症状和有症状个体的鉴定 未接种组。

PROJECT SUMMARY MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV-infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the COVID-19 vaccines. To date, however, there are only anecdotal data on COVID-19 vaccine acceptance and efficacy in people with HIV (PWH). The MWCCS is ideal for analyzing (a) the acceptancy and effects of COVID-19 vaccine(s) in male and female PWH and matched HIV- uninfected controls (HUC), (b) the impact of age and co-morbidities on vaccine immune response and protection against COVID-19, and (c) the social, economic, and behavioral changes after COVID-19 immunization as compared to the individuals who will not take the vaccine. To address this issue, we will have two groups of MWCCS participants: Group A: Male and female PWH and HUC who choose to receive a COVID-19 vaccine, Group B: Male and female PWH and HUC who choose NOT to receive a COVID-19 vaccine. The aims of our proposed longitudinal observational study are: Aim 1: To conduct a mixed-methods investigation of the prevalence, correlates, and nuances of COVID-19 vaccine hesitancy among MWCCS participants. Results will help understand the concerns of PWH and HUC populations regarding COVID-19 vaccines based on age, sex, race/ethnicity, and underlying comorbidity burden. Aim 2: To determine the incidence of natural SARS-CoV-2 infections post-COVID-19 immunization in PWH as compared to HUC of the same age, sex, and ethnicity/race and compare with the incidence of infections in non- vaccinated individuals. We will restrict Aim 2 to obtaining one specimen at baseline, just prior vaccination in Group A, and within comparable time periods for Group B. Subsequent samples collected during the core MWCCS visits will be used in the serological analyzes. These samples will allow us to determine the serological COVID-19 status pre-immunization and post-immunization seroconversions for S and N proteins. The titration of anti-S responses post immunization will indicate vaccine immune response, while anti-N antibody titers will indicate natural SARS-CoV-2 infection. This information will allow the identification of asymptomatic and symptomatic individuals infected with SARS-CoV-2 post-vaccination and in non-vaccinated group.