Green deal inspired correlative imaging-based characterization for safety profiling of 2D materials (ACCORDs)

协议将开发一个基于成像的表征框架（协议框架），用于石墨烯族材料（GFMs）作为二维纳米材料（NMs）的代表进行整体相关评估，以评估和预测二维纳米材料的健康和环境风险。协议框架将通过分层方法将基于低、中、高分辨率物理化学生物成像方法与非成像方法相关联，将过去或正在进行的H2020项目或经合组织内提出的安全和可持续设计（SSbD）战略付诸实施。协议将提供协议框架和用户指南、新的基于成像的表征方法（3-6种方法）、参考体外测试（最多3种新测试）、针对不同矩阵的新参考2D NMs（最多3种）、FAIR数据共享和图像重用的新最低信息报告指南，以及用于GFMs / GFM产品安全性受损诊断的参考图像图谱。新的指导方针和标准提案将提交给标准化机构，以允许创建监管就绪的产品。《协定》的新颖之处在于将基于医学成像的诊断原则转化为二维材料危害诊断。协议将加速航空、海洋建筑、无人机生产、柔性电子、光伏、光催化剂和印刷油墨传感器等领域的工业部门。accord为石墨烯行业提出的价值是实用、简单、基于成像的工具，用于生产线旁的GFM质量监测，并有可能与先进的高分辨率成像表征方法相关联，以防诊断出偏离控制（基准值）的危险。协议框架和工具将通过解决“石墨烯：欧洲领先”的主题，为欧洲绿色协议做出贡献，并为2022年2月2日发布的新的欧洲标准化战略做出贡献。

ACCORDs will develop an imaging-based characterization framework (ACCORDs framework) for the holistic correlative assessment of Graphene Family Materials (GFMs) as a representative of 2D nanomaterials (NMs) to assess and predict 2D NMs health and environmental risks. The ACCORDs framework will operationalise safe and sustainable by design (SSbD) strategies proposed in past or ongoing H2020 projects or within OECD by correlating low-, medium-, and high-resolution physico-chemical-biological imagingbased methods with non-imaging methods in a tiered approach. ACCORDs will deliver the ACCORDs framework and user guidance, new imaging-based characterisation methods (3-6 methods), reference in vitro tests (up to three new tests), new reference 2D NMs (up to three) for different matrices, a new minimum information reporting guideline for FAIR data sharing and reuse of images as well as an atlas with reference images for diagnostics of compromised safety of GFMs / GFM products. The new guidelines and standard proposals will be submitted to standardisation bodies to allow creation of regulatory ready products. The novelty of ACCORDs is in translating the principles of medical imaging-based diagnostics to 2D material hazard diagnostics. ACCORDs will accelerate industrial sectors in the area of aviation, marine construction, drone production, flexible electronics, photovoltaics, photocatalytics and print inks-based sensors. The value ACCORDs proposes to the graphene industry are practical, easy, imaging-based tools for GFM quality monitoring next to the production line with a possibility to be correlated with advanced high-resolution imaging characterization methods in case hazard i.e. deviation from controls (benchmark values) are diagnosed. The ACCORDs framework and tools will contribute to the European Green Deal by addressing the topic: “Graphene: Europe in the lead” and to a new European strategy on standardization, released on 2nd February, 2022.