Neonatal Research Training Program

项目摘要 随着对成人疾病发展起源的认识，迫切需要培养医生 科学家们将解决这些疾病的基本机制，并将这些发现转化为护理， 旨在对人类健康产生持续的、终身的影响。哈佛新生儿- 围产期医学计划有一个>40年的历史，培训医生科学家谁现在领导国家和 国际学术研究项目。我们为我们的培训历史感到自豪，因为我们70%以上的 毕业生（>全国平均水平的2.5倍）成为学术研究员。我们庞大的合格申请人库 再加上哈佛医学院科学界的优秀导师 (HMS)我们的四个培训医院使我们能够在尖端基础，翻译， 临床和健康结果研究。由于解剖学不是一门专门的器官训练学科， 包括器官发育，围产期损伤，生长和发育的机制和过程的研究。 修复，我们的研究和职业培训广泛集中在三个核心学科，代表优势， 哈佛计划，并确定需要新知识的关键领域，为这一特别脆弱的 群体：1）研究正常发育的分子、细胞和表观遗传机制， 围产期损伤; 2）新生儿基因组学研究，以揭示复杂疾病的遗传基础， 将基因测序与模型系统相结合，以揭示基因型-表型相关性， 精准医学治疗策略; 3）干细胞和基因再生医学培训 以治疗为基础的研究，在发展的关键时期治疗新生儿疾病，旨在实现 持续的，终身的影响。该计划的结构化研究培训将灌输技能和知识基础 解决新生儿生物学和围产期健康结果中的这些关键领域。我们高度整合 在科学前沿完成高级教员沿着初级教员作为“培训导师”，因此， 提供了大量的杂交机会。导师计划和奖学金监督 为每一位受训者成立了一个委员会，为他们提供科学和职业发展方面的指导。说教 基础和临床研究培训都需要课程，并辅以相关研讨会， 负责进行研究的课程以及年度研究研讨会。临床实习生 或健康结果研究参加HMS临床有效性计划，大多数获得硕士学位 医学或公共卫生学位。国家专家咨询委员会不断提供咨询意见 候选人和导师的选择，学术进步，和整体成功。战略已经到位， 征聘少数族裔候选人，以确保受训人员的多样性[20名现有研究员中有5名（25%）来自 代表性不足的群体]。我们致力于继续培训和装备学员的工具，以促进和 作为新生儿围产期医学的研究者和领导者，独立进入成功的职业生涯。

Project Summary With the recognition of developmental origins of adult disease, there is a strong need to train physician scientists who will address such fundamental mechanisms of disease and translate these findings to the care of critically ill newborns aiming to have a sustained, life-long impact on human health. The Harvard Neonatal- Perinatal Medicine Program has a >40 year history of training physician scientists who now lead national and international programs in academic neonatology. We are proud of our training history in that >70% of our graduates (>2.5x the national average) become academic neonatologists. Our large pool of eligible applicants combined with highly accomplished mentoring faculty in the scientific community of Harvard Medical School (HMS) and its four training hospitals allows us to train top candidates in cutting edge basic, translational, clinical, and health outcomes research. Since neonatology is not an organ-specific training discipline but encompasses the study of mechanisms and processes of organ development, perinatal injury, growth and repair, our research and career training is broadly focused in three core disciplines that represent strengths of the Harvard Program and define critical areas in need of new knowledge for this particularly vulnerable population: 1) The study of molecular, cellular, and epigenetic mechanisms of normal development and perinatal injury; 2) Investigation in neonatal genomics to uncover the genetic basis of complex disorders by combining gene sequencing with model systems to reveal genotype-phenotype correlations and develop precision medicine-based therapeutic strategies; 3) Training in regenerative medicine with stem cell and gene therapy-based studies to treat neonatal diseases at a critical time of development, aiming to achieve a sustained, life-long impact. The Program's structured research training will instill the skills and knowledge base to address these critical areas in newborn biology and perinatal health outcomes. We incorporate highly accomplished senior faculty at the fore front of science along with junior faculty as `mentors in training', thus providing abundant opportunities for cross fertilization. A mentoring program and scholarship oversight committee is assembled for each trainee to provide mentoring in scientific and career development. Didactic course is required for both basic and clinical research training and supplemented with relevant seminars, a course in the responsible conduct of research as well as an annual research symposium. Trainees in clinical or health outcomes research enroll in the HMS Clinical Effectiveness program and most obtain a Master's Degree in Medical Science or Public Health. Advisory committees of national experts provide on-going advice on candidate and mentor selection, scholarly progress, and overall success. Strategies are in place for the recruitment of minority candidates to ensure a diversity of trainees [5/20 (25%) current fellows came from underrepresented groups]. We are committed to continue to train and equip trainees with tools to advance and move independently into successful careers as investigators and leaders in Neonatal-Perinatal Medicine.