Neonatal Research Training Program

新生儿研究培训计划

• 批准号: 9920176
• 负责人: Stella Kourembanas
• 金额: $ 48.59万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9920176
• 关键词: Neonatal; Research Training; Training Programs

Project Summary With the recognition of developmental origins of adult disease, there is a strong need to train physician scientists who will address such fundamental mechanisms of disease and translate these findings to the care of critically ill newborns aiming to have a sustained, life-long impact on human health. The Harvard Neonatal- Perinatal Medicine Program has a >40 year history of training physician scientists who now lead national and international programs in academic neonatology. We are proud of our training history in that >70% of our graduates (>2.5x the national average) become academic neonatologists. Our large pool of eligible applicants combined with highly accomplished mentoring faculty in the scientific community of Harvard Medical School (HMS) and its four training hospitals allows us to train top candidates in cutting edge basic, translational, clinical, and health outcomes research. Since neonatology is not an organ-specific training discipline but encompasses the study of mechanisms and processes of organ development, perinatal injury, growth and repair, our research and career training is broadly focused in three core disciplines that represent strengths of the Harvard Program and define critical areas in need of new knowledge for this particularly vulnerable population: 1) The study of molecular, cellular, and epigenetic mechanisms of normal development and perinatal injury; 2) Investigation in neonatal genomics to uncover the genetic basis of complex disorders by combining gene sequencing with model systems to reveal genotype-phenotype correlations and develop precision medicine-based therapeutic strategies; 3) Training in regenerative medicine with stem cell and gene therapy-based studies to treat neonatal diseases at a critical time of development, aiming to achieve a sustained, life-long impact. The Program's structured research training will instill the skills and knowledge base to address these critical areas in newborn biology and perinatal health outcomes. We incorporate highly accomplished senior faculty at the fore front of science along with junior faculty as `mentors in training', thus providing abundant opportunities for cross fertilization. A mentoring program and scholarship oversight committee is assembled for each trainee to provide mentoring in scientific and career development. Didactic course is required for both basic and clinical research training and supplemented with relevant seminars, a course in the responsible conduct of research as well as an annual research symposium. Trainees in clinical or health outcomes research enroll in the HMS Clinical Effectiveness program and most obtain a Master's Degree in Medical Science or Public Health. Advisory committees of national experts provide on-going advice on candidate and mentor selection, scholarly progress, and overall success. Strategies are in place for the recruitment of minority candidates to ensure a diversity of trainees [5/20 (25%) current fellows came from underrepresented groups]. We are committed to continue to train and equip trainees with tools to advance and move independently into successful careers as investigators and leaders in Neonatal-Perinatal Medicine.

项目摘要 随着对成人疾病发育性起源的认识，迫切需要培养医生 科学家将解决这些疾病的基本机制，并将这些发现转化为护理 旨在对人类健康产生持续的、终生的影响的危重新生儿。哈佛新生儿- 围产期医学计划有40年的培养内科科学家的历史，这些科学家现在领导着国家和 国际新生儿学术课程。我们为我们的培训历史感到自豪，因为我们70%的员工 毕业生(是全国平均水平的2.5倍)成为学术新生儿专家。我们一大批合格的申请者 与哈佛医学院科学界中成就卓著的指导教师相结合 (HMS)和它的四家培训医院使我们能够在尖端的基础、翻译、 临床和健康结果研究。因为新生儿学不是专门针对器官的训练学科，而是 包括器官发育、围产期损伤、生长和发育的机制和过程的研究 维修，我们的研究和职业培训广泛集中在三个核心学科，代表着优势 哈佛计划并为这一特别脆弱的群体确定需要新知识的关键领域 群体：1)对正常发育和发育的分子、细胞和表观遗传学机制的研究 围产期损伤；2)新生儿基因组研究，以揭示复杂疾病的遗传基础 将基因测序与模型系统相结合，揭示基因-表型相关性并开发 基于精确医学的治疗策略；3)干细胞和基因再生医学培训 以治疗为基础的研究，在发育的关键时期治疗新生儿疾病，旨在实现 持续的、终生的影响。该方案的结构化研究培训将灌输技能和知识基础 以解决新生儿生物学和围产期健康结果中的这些关键领域。我们高度整合 成就卓著的高级教师走在科学前沿，初级教师被评为“培训导师”，因此 为异种受精提供了丰富的机会。指导计划和奖学金监督 委员会为每个受训人员组成，以提供科学和职业发展方面的指导。说教 基础和临床研究培训都需要课程，并辅之以相关的研讨会，a 负责任的研究行为课程以及年度研究研讨会。临床实习生 或健康结果研究注册HMS临床有效性计划，大多数人获得硕士学位 医学或公共卫生专业学位。由国家专家组成的咨询委员会提供持续的建议 关于候选人和导师的选择、学术进步和总体成功。战略已经到位，以应对 征聘少数族裔候选人以确保受训人员的多样性[5/20(25%)现任研究员来自 代表不足的群体]。我们致力于继续培训学员，并为学员配备工具，以促进和 独立进入成功的职业生涯，成为新生儿-围产期医学的研究人员和领导者。