Advancing Interdisciplinary Science of Aging through Identification of Iatrogenic Complications: The UF EHR Clinical Data Infrastructure for Enhanced Patient Safety among the Elderly (UF-ECLIPSE)

项目摘要/摘要 医源性疾病是一个持续的公共卫生问题，估计造成200人死亡。 每年有5万名老年人在美国的医院就诊。医院获得性跌倒和医院- 诱发性精神错乱是最常见和最昂贵的医源性疾病之一，它们的发生是 相互关联。计算技术的进步和电子数据的可用性 更准确地识别有医院获得性跌倒风险的患者的机会 医院诱发的精神错乱。现在，美国约80%的临床数据都是通过电子方式获取的 人口。大约75%-80%的临床数据是文本数据，无法使用传统的 统计方法。开发研究数据基础设施，支持使用文本和 结构化数据对于旨在改善护理和患者结果的学习型卫生系统至关重要。 在这个项目中，我们建议扩展电子数据驱动知识的研究基础设施 通过为患者开发佛罗里达大学(UF)EHR数据基础设施而生成 老年人的安全(UF-ECLIPSE)。我们研究计划的长期目标是加强 通过有效的学习健康减少医源性疾病的住院老年人的安全性 系统。我们计划实现以下目标：具体目标1(R21阶段)：确定和测试可行性 用于处理注册护士(RN)进度记录的文本挖掘管道，用于预测医院获得性 瀑布。我们将结合使用监督和非监督文本挖掘方法来识别文本 与患者跌倒相关的属性。然后，我们将利用患者跌倒风险因素的预测模型 在以前的工作中开发，以生成文本和结构化数据的复合模型，以预测 病人摔倒了。具体目标2(R33阶段)：确定和评价联合国系统的结构和人力资源 扩展研究数据基础设施，以支持持续的跨学科老龄化研究。我们将发展和 试点测试文本挖掘管道，以生成医院诱发精神错乱的预测模型。到时候我们会的 将开发的管道集成到现有的UF健康临床数据仓库(CDW)基础设施中 并进行测试以评估功能、耐用性和可扩展性。此外，我们还建议发展人类 支持数据驱动的跨学科老化研究的资源基础设施。这将通过培训来实现 针对老龄化研究的跨学科数据科学研究生。 UF-ECLIPSE研究小组将是首批实施和测试综合数据储存库的团队之一 它利用护士生成的结构化和文本数据来支持学习健康系统。这项研究将创造 重要的新研究数据基础设施，并将成为医疗保健组织提高安全性的典范 为每天住院的数百万美国老年人提供有效的护理。

Project Summary/Abstract Iatrogenic conditions are a continuing public health concern, causing death among an estimated two hundred and fifty thousand older adults annually in United States (US) hospitals. Hospital-acquired falls and hospital- induced delirium are among the most common and costly iatrogenic conditions, and their occurrences are linked to each other. Advances in computing technology and availability of electronic data presents opportunities to more accurately identify identifying patients at risk of suffering a hospital-acquired fall or hospital-induced delirium. Clinical data is now being captured electronically for about 80% of the US population. Approximately 75-80% of clinical data is text data which cannot be analyzed using traditional statistical methods. The development of a research data infrastructure that supports the use of text and structured data is critical for a learning health system aimed at improving care and patient outcomes. In this project, we propose to expand the research infrastructure for electronic data-driven knowledge generation through the development of the University of Florida (UF) EHR Data Infrastructure for Patient Safety among the Elderly (UF-ECLIPSE). The long-term goal of our research program is to enhance the safety of hospitalized older adults by reducing iatrogenic conditions through an effective learning health system. We plan to carry out the following aims: Specific Aim 1 (R21 Phase): Identify and test the feasibility of text-mining pipelines to process registered nurses' (RNs) progress notes for prediction of hospital-acquired falls. We will employ a combination of supervised and unsupervised text-mining methods to identify text attributes associated with patient falls. We will then leverage a predictive model of patient fall risk factors developed in previous work to generate a composite model of text and structured data to predict the odds of a patient falling. Specific Aim 2 (R33 Phase): Determine and evaluate the structural and human resources of an expanded research-data infrastructure to support sustained interdisciplinary aging studies. We will develop and pilot test text-mining pipelines to generate a prediction model of hospital-induced delirium. We will then integrate the developed pipelines into the existing UF Health Clinical Data Warehouse (CDW) infrastructure and test to assess functionality, durability and scalability. In addition, we propose to develop the human resource infrastructure to support data-driven interdisciplinary aging research. This will be achieved by training graduate students in interdisciplinary data science for aging research. The UF-ECLIPSE research team will be among the first to implement and test an integrated data repository that utilizes nurse-generated structured and text data to support a learning health system. This study will create important new research data infrastructure, and will be a model for health care organizations to increase safe effective care for the millions of older adult Americans hospitalized every day.