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Impact of Delayed Onset Muscle Soreness on Demand for Alcohol and Marijuana among Co-Users

延迟性肌肉酸痛对共同使用者对酒精和大麻需求的影响

基本信息

批准号：
10394130
负责人：
Erin Ferguson
金额：
$ 1.58万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-16 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10394130
关键词：
Absence of pain sensation Acute Pain Address Alcohol abuse Alcohol consumption Alcohols Analgesics Anger Anxiety Area Behavior Behavioral Consumption Control Groups Coping Skills Data Development Distress Doctor of Philosophy Economic Burden Elbow Environment Exercise Expectancy Flexor Frustration General Population Goals Health behavior Individual Intention Intervention Knowledge Lead Marijuana Measures Mediating Medical Marijuana Mentors Methods Muscle Musculoskeletal Pain Neuropharmacology Observational Study Pain Pain management Participant Pattern Prevalence Price Psychometrics Psychosocial Factor Race Recording of previous events Reporting Research Resources Risk Risk Factors Self Medication Severities Sex Differences Substance Use Disorder Testing Time Training Translating Woman Work adverse outcome alcohol demand alcohol risk alcohol use disorder behavioral economic analysis behavioral economics biopsychosocial black men black women chronic pain clinical pain clinically relevant cost efficient craving epidemiology study experience experimental study follow-up functional disability high risk improved marijuana use marijuana use disorder marijuana user men negative affect novel pain patient pain self-management programs psychosocial racial difference sex skill acquisition social substance use

项目摘要

Project Summary/Abstract The overall goal of this proposal is to advance knowledge about pain as a determinant of substance use, particularly alcohol and marijuana use. A substantial body of research indicates that self-medication of pain with alcohol and marijuana (i.e. use to cope with and/or manage pain) is common among pain patients, and epidemiological and observational studies suggest that pain can act as a potent motivator of substance use. Initial experimental evidence suggests that pain can increase urge and intention to consume alcohol, yet this relationship has not been replicated using clinically-relevant pain induction methods with greater ecological validity than typical experimental pain approaches. Further, despite similar pain-inhibitory effects and co- occurring use patterns of alcohol and marijuana, current research has not simultaneously examined the proximal effects of pain on alcohol and marijuana use. Thus, the proposed work will attempt to determine whether experimentally-induced musculoskeletal pain (i.e., delayed onset muscle soreness; DOMS) may increase alcohol and marijuana demand among co-users. An experimental study will be conducted, during which regular co-users of marijuana and alcohol will be assigned to either a DOMS (high-intensity eccentric exercise) or sham DOMS control condition (low-intensity concentric exercise). Overall, the proposed project has two specific aims: 1) to confirm that DOMS results in increased demand for alcohol and marijuana; and to investigate race and sex as moderating factors of this association, and 2) to identify psychosocial risk factors associated with change in demand for alcohol and marijuana after DOMS induction. Results may be used to assist in identification of pain patients at risk for hazardous alcohol and marijuana use. They may also inform development of novel interventions for reducing risk of substance use disorders, particularly among those with pain. The proposed training plan will provide the applicant with additional training beyond that included in her PhD program. Specifically, training goals include 1) hands-on training for experimental research approaches, including musculoskeletal pain induction, 2) coursework in the application of behavioral economic principles to health behaviors in addition to didactic training in administration and analysis of behavioral economic measures, 3) training in advanced statistical approaches, 4) development of professional development skills, and [5) [formal training in neuropharmacology of alcohol and marijuana use, as well as biopsychosocial mechanisms of pain]. The applicant is supported by a strong research environment with the necessary resources for completion of the project and professional development, as well as a productive mentoring team with specific expertise in the proposed areas of study.

项目概要/摘要该提案的总体目标是增进人们对疼痛作为物质使用决定因素的认识，特别是酗酒和吸食大麻。大量研究表明，自我治疗疼痛酒精和大麻（即用于应对和/或控制疼痛）在疼痛患者中很常见，并且流行病学和观察研究表明，疼痛可以成为物质使用的强大动力。初步实验证据表明，疼痛会增加饮酒的冲动和意图，但这使用具有更大生态学意义的临床相关疼痛诱导方法尚未复制这种关系比典型的实验性疼痛方法更有效。此外，尽管具有相似的疼痛抑制作用和共同作用，酒精和大麻的使用模式，目前的研究尚未同时检验疼痛对酒精和大麻使用的近端影响。因此，拟议的工作将尝试确定实验诱发的肌肉骨骼疼痛（即延迟性肌肉酸痛；DOMS）是否可能增加共同使用者对酒精和大麻的需求。期间将进行一项实验研究经常吸食大麻和酒精的人将被分配到 DOMS（高强度怪癖）运动）或假 DOMS 控制条件（低强度同心运动）。总体而言，拟议项目有两个具体目标：1）确认 DOMS 会导致酒精和大麻需求增加；和调查种族和性别作为这种关联的调节因素，2) 识别心理社会风险因素与 DOMS 诱导后对酒精和大麻的需求变化有关。结果可用于协助识别有危险饮酒和吸食大麻风险的疼痛患者。他们也可能会告知制定新的干预措施以降低物质使用障碍的风险，特别是那些患有物质使用障碍的人疼痛。拟议的培训计划将为申请人提供除她所包含的培训之外的额外培训博士课程。具体来说，培训目标包括1）实验研究方法的实践培训，包括肌肉骨骼疼痛诱导，2）应用行为经济学原理的课程除了管理和行为经济分析方面的教学培训之外，还包括健康行为措施，3) 高级统计方法培训，4) 专业发展技能的发展， [5) [关于酒精和大麻使用的神经药理学的正式培训，以及疼痛的生物心理社会机制]。申请人得到强大的研究环境的支持完成项目和专业发展所需的资源，以及富有成效的在拟议的研究领域具有特定专业知识的指导团队。