HERCULES: Exposome Research Center

HERCULES：综合健康科学中心-摘要 与HERCULES核心合作，定义和应用（社区参与核心，CEC）， 解释（环境健康数据科学核心，EHDSC），创新（试点项目计划，PPP），以及 协调和评估（行政核心），综合健康科学设施核心（IHSFC）将 将翻译研究操作化。具体而言，IHSFC将： 支持量化已知危险环境因子的暴露，环境重要的临床 生物标志物和可疑化学品（目标1）;为全球研究已知的 以及与环境暴露或不利环境因素有关的未确定的内源性和外源性化学物质 健康结果（目标2）;为中心提供全面的临床和人口研究服务 科学家（目标3）;并促进人类和社区中的应用转化研究 目标4（Aim 4）利用中心前两轮供资期间建立的坚实基础， IHSFC将在几个关键领域进行扩展：1）在有针对性和无针对性的领域开展非常成功的项目 分析支持，我们将专注于目标1和2在我们的实验室和分析的新创新 方法; 2）研究支持结构，桥梁临床和人口为基础的研究目标3，我们 将强调IHSFC的推广和广泛利用;以及3）建立在经过测试的生物学工具基础上， 技术，我们将强调并优先考虑对Aim中的麻烦进行更广泛的转化研究 4.在这样做的过程中，IHSFC将促进对现有和新出现的环境健康问题的发现 并将促进干预措施的制定、实施和评估，以解决这些问题。 IHSFC的活动将由HERCULES系统和转化研究框架驱动， 纳入社区知识和关切事项。IHSFC团队已经建立了国家和国际 在暴露科学、化学、定量生物学、代谢组学和临床研究方面处于领先地位， 在广泛的环境卫生领域进行人口研究。在中心内，IHFSC将与 CEC旨在增强对暴露相关概念、研究及其重要性的双向理解 HERCULES成员和社区合作伙伴之间的人类健康。IHSFC将继续发挥其关键作用， EHDSC的驱动程序，特别是提供数据，提高EHDSC的利用率，并促进 麻烦相关的工具。IHSFC将支持寻求向PPP提交提案的调查人员， 支持公私伙伴关系资助的新研究项目，促进翻译和整合与基因组相关的 研究数据、工具和概念。此外，IHSFC将与行政核心密切合作， 转化研究规划，以增加培训机会，并确保IHSFC的目标是 通过跟踪和评估，确保其服务满足中心成员的需求。

HERCULES: INTEGRATED HEALTH SCIENCES FACILITY CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), enable and interpret (Environmental Health Data Sciences Core, EHDSC), innovate (Pilot Project Program, PPP), and coordinate and evaluate (Administrative Core), the Integrated Health Sciences Facility Core (IHSFC) will operationalize translational research on the exposome. Specifically, the IHSFC will: deliver targeted analytical support to quantify exposures to known hazardous environmental agents, environmentally-important clinical biomarkers, and suspect chemicals (Aim 1); provide untargeted analytical support for global study of known and unidentified endogenous and exogenous chemicals associated with environmental exposures or adverse health outcomes (Aim 2); offer comprehensive clinical and population research services to Center-based scientists (Aim 3); and catalyze applied translational research on the exposome in humans and in communities of interest (Aim 4). Drawing on the strong foundation developed during the first two rounds of Center funding, the IHSFC will expand in several key areas: 1) with the very successful programs in targeted and untargeted analytical support, we will focus in Aims 1 and 2 on new innovations within our laboratory and analytical methods; 2) with research support structure that bridges clinical and population-based research in Aim 3, we will emphasize outreach and broad utilization of the IHSFC; and 3) building on tested exposomics tools and technology, we will emphasize and prioritize a broader vision of translational research on the exposome in Aim 4. In doing so, the IHSFC will promote discovery in established and emerging environmental health concerns and will foster development, implementation, and assessment of interventions to address these concerns. IHSFC activities will be driven by the HERCULES exposome and translational research frameworks that incorporate community knowledge and concerns. The IHSFC team has established national and international research leadership in exposure science, chemistry, quantitative biology, metabolomics, and clinical and population studies in broad environmental health areas. Within the Center, the IHFSC will work closely with the CEC to enhance bidirectional understanding of exposome-related concepts, research, and their importance in human health among HERCULES Member and community partners. The IHSFC will continue its key role as a driver of the EHDSC, specifically to deliver data, enhance EHDSC utilization, and facilitate development of exposome-related tools. The IHSFC will support investigators seeking to submit proposals to the PPP and will support PPP-funded novel research projects that facilitate translation and integration of exposome-related research data, tools and concepts. Moreover, the IHSFC will work closely with the Administrative Core in translational research planning, to enhance training opportunities, and to ensure that IHSFC aims are being met and that its services are meeting the needs of Center Members, through tracking and evaluation.