HERCULES: Exposome Research Center

大力神：综合健康科学设施核心-摘要 与定义和应用(社区参与核心，CEC)的Hercules核心合作，支持和 解释(环境健康数据科学核心，EHDSC)、创新(试点项目计划，PPP)和 协调和评估(行政核心)，综合健康科学设施核心(IHSFC)将 将翻译性研究付诸实施。具体而言，IHSFC将：提供有针对性的分析 支持量化暴露于已知有害环境物质、对环境重要的临床环境 生物标志物和可疑化学品(目标1)；为已知的全球研究提供无针对性的分析支持 以及与环境暴露或有害物质有关的不明内源和外源化学品 健康结果(目标2)；向中心提供全面的临床和人口研究服务 科学家(目标3)；并在人类和社区中催化对曝光组的应用翻译研究 感兴趣(目标4)。凭借中心在前两轮资助中形成的雄厚基础， IHSFC将在几个关键领域进行扩展：1)在有针对性和无针对性的项目中非常成功 分析支持，我们将在目标1和2中重点关注我们实验室内的新创新和分析 方法；2)在目标3中，通过连接临床研究和基于人群的研究的研究支持结构，我们 将强调IHSFC的推广和广泛利用；以及3)建立在经过测试的曝光组学工具和 技术，我们将强调并优先考虑对AIM中的曝光组进行翻译研究的更广泛的视野 4.通过这样做，IHSFC将促进发现已有的和新出现的环境健康问题 并将促进制定、实施和评估干预措施，以解决这些关切。 IHSFC的活动将由Hercules Exposome和翻译研究框架推动，这些框架 融入社区知识和关切。IHSFC团队在国内和国际上建立了 在暴露科学、化学、定量生物学、代谢组学、临床和 广泛环境卫生领域的人口研究。在该中心内，IHFSC将与 CEC加强对曝光组相关概念、研究及其在 大力神成员和社区伙伴之间的人类健康。IHSFC将继续发挥其作为 EHDSC的驱动程序，特别是提供数据，提高EHDSC利用率，并促进 曝光组相关工具。IHSFC将支持寻求向PPP提交提案的调查人员，并将 支持PPP资助的新研究项目，促进与曝光组相关的翻译和集成 研究数据、工具和概念。此外，IHSFC将在#年与行政核心密切合作 翻译研究计划，以增加培训机会，并确保IHSFC的目标正在实现 通过跟踪和评估，该中心的服务满足了中心成员的需求。

HERCULES: INTEGRATED HEALTH SCIENCES FACILITY CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), enable and interpret (Environmental Health Data Sciences Core, EHDSC), innovate (Pilot Project Program, PPP), and coordinate and evaluate (Administrative Core), the Integrated Health Sciences Facility Core (IHSFC) will operationalize translational research on the exposome. Specifically, the IHSFC will: deliver targeted analytical support to quantify exposures to known hazardous environmental agents, environmentally-important clinical biomarkers, and suspect chemicals (Aim 1); provide untargeted analytical support for global study of known and unidentified endogenous and exogenous chemicals associated with environmental exposures or adverse health outcomes (Aim 2); offer comprehensive clinical and population research services to Center-based scientists (Aim 3); and catalyze applied translational research on the exposome in humans and in communities of interest (Aim 4). Drawing on the strong foundation developed during the first two rounds of Center funding, the IHSFC will expand in several key areas: 1) with the very successful programs in targeted and untargeted analytical support, we will focus in Aims 1 and 2 on new innovations within our laboratory and analytical methods; 2) with research support structure that bridges clinical and population-based research in Aim 3, we will emphasize outreach and broad utilization of the IHSFC; and 3) building on tested exposomics tools and technology, we will emphasize and prioritize a broader vision of translational research on the exposome in Aim 4. In doing so, the IHSFC will promote discovery in established and emerging environmental health concerns and will foster development, implementation, and assessment of interventions to address these concerns. IHSFC activities will be driven by the HERCULES exposome and translational research frameworks that incorporate community knowledge and concerns. The IHSFC team has established national and international research leadership in exposure science, chemistry, quantitative biology, metabolomics, and clinical and population studies in broad environmental health areas. Within the Center, the IHFSC will work closely with the CEC to enhance bidirectional understanding of exposome-related concepts, research, and their importance in human health among HERCULES Member and community partners. The IHSFC will continue its key role as a driver of the EHDSC, specifically to deliver data, enhance EHDSC utilization, and facilitate development of exposome-related tools. The IHSFC will support investigators seeking to submit proposals to the PPP and will support PPP-funded novel research projects that facilitate translation and integration of exposome-related research data, tools and concepts. Moreover, the IHSFC will work closely with the Administrative Core in translational research planning, to enhance training opportunities, and to ensure that IHSFC aims are being met and that its services are meeting the needs of Center Members, through tracking and evaluation.