HERCULES: Exposome Research Center

HERCULES：暴露研究中心

• 批准号: 10668224
• 负责人: Stefanie Ebelt
• 金额: $ 40.87万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668224
• 关键词: Address; Animals; Area; Basic Science; Bioinformatics; Biological; Biological Markers; Biological Models; Biology; Cell Culture Techniques; Chemicals; Chemistry; Clinical; Clinical Management; Clinical Research; Clinical Sciences; Collaborations; Communities; Core Facility; Data; Data Science Core; Development; Discipline; Disease; Environment; Environmental Exposure; Environmental Health; Evaluation; Evaluation Research; Exposure to; Fostering; Foundations; Funding; Health; Health Sciences; Human; International; Intervention; Knowledge; Laboratories; Leadership; Life; Liquid substance; Mass Spectrum Analysis; Measures; Methods; Mission; National Institute of Environmental Health Sciences; Outcome; Phenotype; Pilot Projects; Population; Population Research; Population Study; Public Health; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Role; Science; Scientific Inquiry; Scientist; Services; Structure; Technology; Testing; Time; Translational Research; Translations; Vision; Work; analytical method; chemical association; clinical biomarkers; community engagement; complex biological systems; design; environmental agent; environmental chemical; epidemiology study; human tissue; innovation; interest; investigator training; laboratory facility; meetings; member; metabolome; metabolomics; novel; outreach; population based; programs; research facility; response; success; tissue culture; tool; training opportunity

HERCULES: INTEGRATED HEALTH SCIENCES FACILITY CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), enable and interpret (Environmental Health Data Sciences Core, EHDSC), innovate (Pilot Project Program, PPP), and coordinate and evaluate (Administrative Core), the Integrated Health Sciences Facility Core (IHSFC) will operationalize translational research on the exposome. Specifically, the IHSFC will: deliver targeted analytical support to quantify exposures to known hazardous environmental agents, environmentally-important clinical biomarkers, and suspect chemicals (Aim 1); provide untargeted analytical support for global study of known and unidentified endogenous and exogenous chemicals associated with environmental exposures or adverse health outcomes (Aim 2); offer comprehensive clinical and population research services to Center-based scientists (Aim 3); and catalyze applied translational research on the exposome in humans and in communities of interest (Aim 4). Drawing on the strong foundation developed during the first two rounds of Center funding, the IHSFC will expand in several key areas: 1) with the very successful programs in targeted and untargeted analytical support, we will focus in Aims 1 and 2 on new innovations within our laboratory and analytical methods; 2) with research support structure that bridges clinical and population-based research in Aim 3, we will emphasize outreach and broad utilization of the IHSFC; and 3) building on tested exposomics tools and technology, we will emphasize and prioritize a broader vision of translational research on the exposome in Aim 4. In doing so, the IHSFC will promote discovery in established and emerging environmental health concerns and will foster development, implementation, and assessment of interventions to address these concerns. IHSFC activities will be driven by the HERCULES exposome and translational research frameworks that incorporate community knowledge and concerns. The IHSFC team has established national and international research leadership in exposure science, chemistry, quantitative biology, metabolomics, and clinical and population studies in broad environmental health areas. Within the Center, the IHFSC will work closely with the CEC to enhance bidirectional understanding of exposome-related concepts, research, and their importance in human health among HERCULES Member and community partners. The IHSFC will continue its key role as a driver of the EHDSC, specifically to deliver data, enhance EHDSC utilization, and facilitate development of exposome-related tools. The IHSFC will support investigators seeking to submit proposals to the PPP and will support PPP-funded novel research projects that facilitate translation and integration of exposome-related research data, tools and concepts. Moreover, the IHSFC will work closely with the Administrative Core in translational research planning, to enhance training opportunities, and to ensure that IHSFC aims are being met and that its services are meeting the needs of Center Members, through tracking and evaluation.

HERCULES：综合健康科学设施核心 – 摘要 与定义和应用的 HERCULES 核心（社区参与核心，CEC）合作，启用和 解释（环境健康数据科学核心，EHDSC），创新（试点项目计划，PPP），以及 协调和评估（管理核心），综合健康科学设施核心（IHSFC）将 实施暴露组的转化研究。具体来说，IHSFC 将： 提供有针对性的分析 支持量化已知有害环境因子的暴露、对环境重要的临床 生物标志物和可疑化学品（目标 1）；为已知的全球研究提供无针对性的分析支持 以及与环境暴露或不利影响相关的未识别的内源性和外源性化学物质 健康成果（目标 2）；为中心提供全面的临床和人口研究服务 科学家（目标 3）；并促进人类和社区暴露组的应用转化研究 兴趣（目标 4）。凭借前两轮中心资助所建立的坚实基础， IHSFC 将在几个关键领域进行扩展：1）在有针对性和无针对性的方面开展非常成功的计划 分析支持，我们将重点关注目标 1 和 2 我们实验室和分析领域的新创新 方法; 2) 借助连接目标 3 中的临床研究和基于人群的研究的研究支持结构，我们 将强调 IHSFC 的推广和广泛利用； 3）建立在经过测试的暴露组学工具的基础上 技术，我们将强调并优先考虑 Aim 中暴露组转化研究的更广泛愿景 4. 在此过程中，IHSFC 将促进对已确定的和新出现的环境健康问题的发现 并将促进干预措施的制定、实施和评估，以解决这些问题。 IHSFC 的活动将由 HERCULES 暴露组和转化研究框架驱动， 纳入社区知识和关注点。 IHSFC 团队已建立国内和国际 在暴露科学、化学、定量生物学、代谢组学以及临床和临床领域的研究领导地位 广泛的环境健康领域的人口研究。在该中心内，IHFSC 将与 CEC 旨在加强对暴露组相关概念、研究及其重要性的双向理解 HERCULES 会员和社区合作伙伴之间的人类健康。 IHSFC 将继续发挥其作为 EHDSC 的驱动程序，专门用于传输数据、增强 EHDC 利用率并促进开发 暴露相关的工具。 IHSFC 将支持调查人员向 PPP 提交提案，并将 支持 PPP 资助的新颖研究项目，促进暴露组相关研究的转化和整合 研究数据、工具和概念。此外，IHSFC 将与行政核心密切合作， 转化研究规划，增加培训机会，并确保 IHSFC 的目标得以实现 通过跟踪和评估，其服务满足了中心成员的需求。