HERCULES: Exposome Research Center

大力神：环境健康数据科学核心-摘要 与定义和应用(社区参与核心，CEC)、创新(试点)的Hercules核心合作 项目计划，PPP)，运营(综合健康科学设施核心(IHSFC)，并协调和 评估(管理核心)，环境健康数据科学核心(EHDSC)功能，以实现 并解读了关于展示录的翻译研究。具体地说，EHDSC将：1)开发和支持 将各种Hercules成员的数据集与大小项目连接起来的数据管道(目标1)； 推进扩展和定制的数据管理和分析计划，实施新的分析 方法，并扩展Hercules数据和分析基础设施(目标2)；和3)提供深入的 面向Hercules成员和合作伙伴的介绍和培训课程，重点是数据科学原理， 统计和机器学习设计和分析，以及计算系统的分析建模工具 生物学(目标3)。这三个函数对于转换不同测量的曝光组相关数据是必不可少的 在不同时间从不同地方获取的类型转化为可提供信息的、可解释的和可传达的结果 社区成员、利益相关者、研究人员和政策制定者。建立在互联协作的基础上 我们经验丰富的数据科学专业人员与Hercules成员和社区之间的网络 合作伙伴，EHDSC将1)为行政核心提供对以下方面的现有和新出现的趋势的洞察 来自Hercules社区内外的数据管理和分析，以确保培训 所有成员和对新的和早期职业调查人员的支持；2)直接与CEC合作 与Hercules社区合作伙伴合作，确定相关的现有数据源，与 Hercules成员，和/或支持公民科学工作，以提供数据收集、数据管理和 数据通信计划；3)与IHFSC合作，在#年将健康结果和暴露测量联系起来 以创新的方式量化、操作和解释翻译中的暴露数据 环境健康研究；4)加快试点项目的创新研究，提供 需要在一系列数据科学需求方面提供支持。总而言之，EHDSC提供了明确的 连接到Hercules的所有元素，并补充行政核心、CEC、飞行员 计划，通过与IHSFC的密切合作，了解我们的总体使命是如何曝光的 影响健康和社区福祉，并利用这些知识改善人类健康。

HERCULES: ENVIRONMENTAL HEALTH DATA SCIENCE CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), innovate (Pilot Project Program, PPP), operationalize (Integrated Health Sciences Facility Core (IHSFC), and coordinate and evaluate (Administrative Core), the Environmental Health Data Sciences Core (EHDSC) functions to enable and interpret translational research on the exposome. Specifically, the EHDSC will: 1) Develop and support data pipelines linking the wide range of HERCULES Members’ datasets to projects large and small (Aim 1); 2) Advance expanded and customized data management and analysis plans, implement novel analytic approaches, and expand the HERCULES data and analytic infrastructure (Aim 2); and 3) Provide in-depth introductions and training sessions for HERCULES Members and partners focusing on data science principles, statistical and machine learning design and analysis, and analytic modeling tools of computational systems biology (Aim 3). All three functions are essential to translate exposome-related data of different measurement types taken from different places at different times into informative, interpretable, and communicable results for community members, stakeholders, researchers, and policy makers. Building on a connected collaborative network between our experienced data science professionals and HERCULES Members and community partners, the EHDSC will 1) provide the Administrative Core with insight into existing and emerging trends in data management and analysis from inside and outside the HERCULES community in order to assure training of all Members and support for new and early career investigators; 2) collaborate directly with the CEC in working with HERCULES community partners to identify relevant existing data sources, partnerships with HERCULES Members, and/or support citizen science efforts to provide data collection, data management, and data communication plans; 3) partner with the IHFSC to link health outcomes and exposure measurements in innovative ways quantifying, operationalizing, and interpreting exposome data within translational environmental health research; 4) accelerate the innovative research of the Pilot Program by providing needed support across a range of data science needs. Taken together, the EHDSC provides clear connections to all elements of HERCULES and complements the Administrative Core, the CEC, the Pilot Program, and the IHSFC through close collaboration in our overall mission of learning how the exposome affects health and community well-being and using that knowledge to improve human health.