HERCULES: Exposome Research Center

HERCULES：暴露研究中心

• 批准号: 10668226
• 负责人: Lance A Waller
• 金额: $ 29.08万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668226
• 关键词: Acceleration; Affect; Behavior; Bioinformatics; Biometry; Characteristics; Collaborations; Communities; Complement; Connective Tissue; Core Facility; Cost Sharing; Data; Data Analyses; Data Collection; Data Element; Data Science; Data Science Core; Data Scientist; Data Set; Data Sources; Disease; Educational workshop; Elements; Environmental Health; Foundations; Funding; Future; Generations; Genomics; Goals; Health; Health Sciences; Human; Incubated; Individual; Informatics; Infrastructure; Institution; Knowledge; Learning; Link; Machine Learning; Measurable; Measurement; Methods; Mind; Mission; Modeling; Monitor; National Institute of Environmental Health Sciences; Outcome; Personal Satisfaction; Pilot Projects; Policies; Policy Maker; Postdoctoral Fellow; Proteomics; Recording of previous events; Reproducibility; Research; Research Personnel; Research Project Grants; Science; Scientist; Software Tools; Source; Students; Systems Biology; Techniques; Time; Training; Translating; Translational Research; analytical tool; archive data; built environment; career; citizen science; community based participatory research; community engagement; community partnership; community setting; computerized tools; data communication; data management; data pipeline; data repository; data sharing; data standards; design; diverse data; experience; field study; graduate student; improved; innovation; insight; mathematical model; member; metabolomics; multiple data types; next generation; novel; operation; programs; remote sensing; response; science teacher; statistical and machine learning; success; tool; training opportunity; transcriptomics; trend

HERCULES: ENVIRONMENTAL HEALTH DATA SCIENCE CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), innovate (Pilot Project Program, PPP), operationalize (Integrated Health Sciences Facility Core (IHSFC), and coordinate and evaluate (Administrative Core), the Environmental Health Data Sciences Core (EHDSC) functions to enable and interpret translational research on the exposome. Specifically, the EHDSC will: 1) Develop and support data pipelines linking the wide range of HERCULES Members’ datasets to projects large and small (Aim 1); 2) Advance expanded and customized data management and analysis plans, implement novel analytic approaches, and expand the HERCULES data and analytic infrastructure (Aim 2); and 3) Provide in-depth introductions and training sessions for HERCULES Members and partners focusing on data science principles, statistical and machine learning design and analysis, and analytic modeling tools of computational systems biology (Aim 3). All three functions are essential to translate exposome-related data of different measurement types taken from different places at different times into informative, interpretable, and communicable results for community members, stakeholders, researchers, and policy makers. Building on a connected collaborative network between our experienced data science professionals and HERCULES Members and community partners, the EHDSC will 1) provide the Administrative Core with insight into existing and emerging trends in data management and analysis from inside and outside the HERCULES community in order to assure training of all Members and support for new and early career investigators; 2) collaborate directly with the CEC in working with HERCULES community partners to identify relevant existing data sources, partnerships with HERCULES Members, and/or support citizen science efforts to provide data collection, data management, and data communication plans; 3) partner with the IHFSC to link health outcomes and exposure measurements in innovative ways quantifying, operationalizing, and interpreting exposome data within translational environmental health research; 4) accelerate the innovative research of the Pilot Program by providing needed support across a range of data science needs. Taken together, the EHDSC provides clear connections to all elements of HERCULES and complements the Administrative Core, the CEC, the Pilot Program, and the IHSFC through close collaboration in our overall mission of learning how the exposome affects health and community well-being and using that knowledge to improve human health.

HERCULES：环境健康数据科学核心-摘要 与HERCULES核心合作，定义和应用（社区参与核心，CEC），创新（试点 项目计划，PPP），运作（综合健康科学设施核心（IHSFC），并协调和 评估（行政核心），环境健康数据科学核心（EHDSC）的职能，使 并对翻译研究中的疑难问题进行解读。具体而言，EHDSC将：1）开发和支持 将HERCULES成员的广泛数据集与大小项目连接起来的数据管道（目标1）; 2） 推进扩展和定制的数据管理和分析计划，实施新的分析 方法，并扩展HERCULES数据和分析基础设施（目标2）;以及3）提供深入的 为HERCULES成员和合作伙伴举办介绍和培训课程，重点是数据科学原理， 统计和机器学习设计和分析，以及计算系统的分析建模工具 生物学（目标3）。所有这三个功能对于转换不同测量值的故障相关数据都是必不可少的 从不同的地方在不同的时间采取的类型到信息，可解释和可传达的结果， 社区成员、利益相关者、研究人员和政策制定者。建立在互联的协作基础上 我们经验丰富的数据科学专业人员与HERCULES会员和社区之间的网络 EHDSC将1）为行政核心提供对现有和新兴趋势的洞察力， 来自HERCULES社区内外的数据管理和分析，以确保培训 所有成员和支持新的和早期的职业调查员; 2）直接与CEC合作， 与HERCULES社区合作伙伴合作，确定相关的现有数据源，与 HERCULES成员，和/或支持公民科学工作，提供数据收集，数据管理， 数据交流计划; 3）与IHFSC合作，将健康结果和暴露测量联系起来， 以创新的方式量化、操作和解释翻译过程中的麻烦数据 环境健康研究; 4）通过提供服务，加速试点项目的创新研究 在一系列数据科学需求中需要支持。总的来说，EHDSC提供了明确的 连接到HERCULES的所有元素，并补充行政核心，CEC，飞行员 计划，和IHSFC通过密切合作，在我们的整体使命的学习如何麻烦 影响健康和社区福祉，并利用这些知识来改善人类健康。