Core Grant for Vision Research

摘要 该 P30 更新提案要求继续提供资金，以支持内部五个资源模块的运作 匹兹堡大学眼科和视觉科学研究中心（OVSRC）。 OVSRC 为四个部门的约 25 名视觉科学家提供基础和临床视觉研究的基地 匹兹堡大学和卡内基梅隆大学的两个系。这些创新性的工作 科学家们正在推进我们对角膜细胞生物学和再生的了解；青光眼（影像学、小梁 网状干细胞生物学和基于干细胞的疗法，以及眼部生物力学）；视网膜和RPE 发育、退化和再生；视觉神经科学；眼部感染性疾病；眼部的 免疫学；眼部微生物组；和视觉/皮质假肢等领域。我们是一个大学生， 协作且富有成效的研究人员小组；我们的 18 名视觉科学家拥有 23 项资格 NEI 资助的 R01 资助，一位视觉科学家拥有两项与视觉高度相关的 R01 资助，这些资助通过 其他 NIH 机构中，两名视觉科学家持有 NEI 的 R00 资助，一名视觉科学家持有 K08 NEI 颁发的奖项。核心补助金的其余参与教师要么拥有与视觉相关的重要知识 来自国防部或 DARPA 的资助，或者他们是正在生成试点数据的新调查员 提交第一笔 NEI/NIH R01 资助。重要的是，这些新研究人员中的许多人已经 成功获得视觉研究基金会的种子资金以支持其研究项目。结束 在过去的 29 年里，视觉研究核心补助金在增强 NEI 资助的 我们参与教师的研究，并支持新教师建立他们的愿景研究项目。 在此续签申请中，核心补助金将继续提供资源、服务和技术， 对于匹兹堡大学和卡内基大学正在进行的视觉研究工作的成功至关重要 梅隆大学。核心拨款通过以下方式增强匹兹堡的整体视觉研究环境：1) 提供对视觉科学家的成功至关重要的核心资源； 2）加强合作 匹兹堡地区的视觉科学家，3) 协助匹兹堡招募新的视觉科学家，以及 4) 为视觉科学学生和研究员的高级培训提供智力和技术支持。

SUMMARY This P30 renewal proposal requests continued funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) of the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research for ~25 vision scientists in four departments of the University of Pittsburgh and two departments of Carnegie Mellon University. The innovative work of these scientists is advancing our knowledge of corneal cell biology and regeneration; glaucoma (imaging, trabecular meshwork stem cell biology and stem cell based therapeutics, and ocular biomechanics); retinal and RPE development, degeneration and regeneration; visual neuroscience; ocular infectious disease; ocular immunology; the ocular microbiome; and visual/cortical prosthetics, among other areas. We are a collegial, collaborative and productive group of researchers; eighteen of our vision scientists hold twenty-three qualifying NEI-funded R01 grants, one vision scientist holds two highly vision-related R01 grants that are funded through other NIH institutes, two vision scientists hold R00 grants from the NEI, and one vision scientist holds a K08 award from the NEI. The remaining participating faculty in the Core Grant either hold significant vision-related grants from the Department of Defense or DARPA, or they are new investigators that are generating pilot data for submission of their first NEI/NIH R01 grants. Importantly, many of these new investigators have already been successful in obtaining seed grants from vision research foundations to support their research programs. Over the last 29 years, the Core Grant for Vision Research has played a central role in enhancing the NEI-funded research of our participating faculty, and supporting new faculty in establishing their vision research programs. In this renewal application, the Core Grant will continue to provide resources, services, and technologies that are essential to the success of the vision research efforts underway at the University of Pittsburgh and Carnegie Mellon University. The Core Grant enhances the overall vision research environment in Pittsburgh by: 1) providing core resources that are critical to the success of vision scientists; 2) enhancing collaboration among vision scientists in the Pittsburgh area, 3) aiding in the recruitment of new vision scientists to Pittsburgh, and 4) providing intellectual and technical support for the advanced training of students and fellows in vision sciences.