Core Grant for Vision Research

摘要 这份P30续订提案要求继续提供资金，以支持以下五个资源模块的运作 匹兹堡大学眼科和视觉科学研究中心(OVSRC)。OVSRC 为四个部门的约25名视觉科学家提供基础和临床视力研究的大本营 匹兹堡大学和卡内基梅隆大学的两个系。这些机构的创新工作 科学家正在推进我们关于角膜细胞生物学和再生的知识；青光眼(成像，小梁 网络干细胞生物学和干细胞治疗学，以及眼生物力学)；视网膜和RPE 发育、退化和再生；视觉神经科学；眼部感染性疾病；眼部 免疫学；眼部微生物组；以及视觉/皮质假体等领域。我们是合议制的， 协作和富有成效的研究人员团队；我们的18名视力科学家拥有23名合格的 NEI资助的R01奖助金，一位视觉科学家持有两个高度与视觉相关的R01奖助金，这两个奖助金是通过 在美国国立卫生研究院的其他研究所中，两名视觉科学家获得了NEI的R00奖金，一名视觉科学家获得了K08 由NEI颁发的奖项。核心助学金中剩余的参与教员要么持有与视觉相关的重要信息 来自国防部或DARPA的拨款，或者他们是正在生成飞行员数据的新调查人员 用于提交他们的第一笔NEI/NIH R01赠款。重要的是，这些新调查人员中的许多人已经 成功地从VISION研究基金会获得种子赠款，以支持他们的研究计划。完毕 在过去的29年里，视力研究核心补助金在加强NEI资助的 研究我们的参与教员，并支持新教员建立他们的视觉研究计划。 在此次续订申请中，Core Grant将继续提供下列资源、服务和技术 对于匹兹堡大学和卡内基大学正在进行的视觉研究工作的成功至关重要 梅隆大学。核心助学金通过以下方式提升匹兹堡的整体视觉研究环境：1) 提供对视觉科学家的成功至关重要的核心资源；2)加强 匹兹堡地区的视觉科学家，3)帮助匹兹堡招募新的视觉科学家，以及4) 为学生和研究员在视觉科学方面的高级培训提供智力和技术支持。

SUMMARY This P30 renewal proposal requests continued funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) of the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research for ~25 vision scientists in four departments of the University of Pittsburgh and two departments of Carnegie Mellon University. The innovative work of these scientists is advancing our knowledge of corneal cell biology and regeneration; glaucoma (imaging, trabecular meshwork stem cell biology and stem cell based therapeutics, and ocular biomechanics); retinal and RPE development, degeneration and regeneration; visual neuroscience; ocular infectious disease; ocular immunology; the ocular microbiome; and visual/cortical prosthetics, among other areas. We are a collegial, collaborative and productive group of researchers; eighteen of our vision scientists hold twenty-three qualifying NEI-funded R01 grants, one vision scientist holds two highly vision-related R01 grants that are funded through other NIH institutes, two vision scientists hold R00 grants from the NEI, and one vision scientist holds a K08 award from the NEI. The remaining participating faculty in the Core Grant either hold significant vision-related grants from the Department of Defense or DARPA, or they are new investigators that are generating pilot data for submission of their first NEI/NIH R01 grants. Importantly, many of these new investigators have already been successful in obtaining seed grants from vision research foundations to support their research programs. Over the last 29 years, the Core Grant for Vision Research has played a central role in enhancing the NEI-funded research of our participating faculty, and supporting new faculty in establishing their vision research programs. In this renewal application, the Core Grant will continue to provide resources, services, and technologies that are essential to the success of the vision research efforts underway at the University of Pittsburgh and Carnegie Mellon University. The Core Grant enhances the overall vision research environment in Pittsburgh by: 1) providing core resources that are critical to the success of vision scientists; 2) enhancing collaboration among vision scientists in the Pittsburgh area, 3) aiding in the recruitment of new vision scientists to Pittsburgh, and 4) providing intellectual and technical support for the advanced training of students and fellows in vision sciences.