In vivo Fractional Blood Volume: Contributions to Renal BOLD MRI.

体内血容量分数：对肾脏 BOLD MRI 的贡献。

• 批准号: 10395426
• 负责人: POTTUMARTHI V PRASAD
• 金额: $ 19.67万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-20 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10395426
• 关键词: Anemia; Back; Blood; Blood Vessels; Blood Volume; Blood flow; Chronic Kidney Failure; Clinical; Contrast Media; Data; Development; Diuresis; Diuretics; Dose; Furosemide; Hematocrit procedure; Hemoglobin; Human; Hydration status; Hypoxia; Individual; Kidney; Kidney Diseases; Label; Laboratories; Lead; Magnetic Resonance Imaging; Maps; Measures; Methods; Microfils; Outcome; Peripheral; Pharmaceutical Preparations; Positron-Emission Tomography; Rattus; Renal function; Reporting; Research Personnel; Resolution; Role; Signal Transduction; Specificity; Techniques; Time; Tissues; base; blood oxygen level dependent; cohort; density; ferumoxytol; imaging biomarker; improved; in vivo; interest; kidney medulla; trend; young adult

Our laboratory has pioneered the use of blood oxygenation level dependent (BOLD) MRI the kidneys as a way of evaluating its oxygenation status. Several investigators around the world have validated the technique. However, it remains as a qualitative measure and its specificity to oxygenation is not validated. Even though it is known theoretically that a role exists for the fractional blood volume (fraction of the tissue occupied by blood vessels) in BOLD MRI, with the lack of data it has been tacitly assumed to be either small or non-existent. However, recent developments allow us to measure regional fBV using blood pool contrast agents. Here, we want to for the first time measure regional fBV in human kidneys and see (i) whether it is different in cortex and medulla; (ii) whether medullary fBV reduces when administering furosemide as suggested by recent data in rat kidneys; and (iii) whether regional fBV is reduced in individuals with chronic kidney disease (CKD). If the proposed study is successful, it may support the use of fBV as an independent imaging marker. In addition, the data will have a significant impact on the interpretation of renal BOLD MRI data.

我们的实验室已经率先使用血液氧合水平依赖(BOLD)磁共振肾脏作为一种方法 评估它的氧合状态。世界各地的几名研究人员已经验证了这项技术。 然而，它仍然是一个定性的指标，它对氧合的特异性还没有得到验证。即使它 从理论上讲，分数血容量(血液所占组织的分数)存在一定的作用 血管)在大胆的磁共振成像中，由于缺乏数据，它要么被默认为很小，要么不存在。 然而，最近的发展使我们能够使用血池造影剂来测量局部FBV。 在这里，我们想要第一次测量人类肾脏的局部FBV，并看看(I)它在 皮质和髓质；(Ii)使用速尿是否如最近提出的那样减少了延髓的FBV 在大鼠肾脏中的数据；以及(Iii)慢性肾脏疾病(CKD)患者的局部FBV是否降低。 如果拟议的研究成功，可能会支持将FBV用作独立的成像标志物。在……里面 此外，这些数据将对解释肾脏BOLD MRI数据产生重大影响。