BOLD MRI: Application to Intrarenal Oxygenation
BOLD MRI:在肾内氧合中的应用
基本信息
- 批准号:6999767
- 负责人:
- 金额:$ 42.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-02-01 至 2008-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
Hypertension, also known as high blood pressure, affects one in four adults in the United States, and is a major risk factor for stroke, heart attack and kidney disease. It is sometimes called the "silent killer" because it often has no symptoms. Progress towards preventing and curing hypertension has been impeded by a lack of thorough understanding of its underlying pathophysiology. Significant progress made over the last decade in vascular biology has allowed for better understanding of many of the underlying mechanisms, which then has led to development of novel drug treatments for hypertension. Many now believe that kidney plays an important role in the pathophysiology of hypertension. Specifically, it is thought that renal medullary blood flow has a direct influence on hypertension. It is still a topic of debate as to the alterations in the kidney being the cause or the consequence of hypertension. In either case, availability of a non-invasive method to probe blood flow at a regional level within the kidney would allow for verifying many of the hypotheses to be tested in humans. Based on previous experience with blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) technique to the kidney, we hypothesize that the technique would be sensitive to changes in medullary blood flow. More specifically, we believe that the technique in combination with suitable endothelium-dependent vasoactive agents would allow for renal microvascular reactivity studies to be performed in a non-invasive way. Vascular reactivity studies look for responses in the vessel walls to vasoactive substances or physiological paradigms that elicit an endogenous vasoactive response. It is believed that these functional changes at the microvascular level take place much earlier than the development of hypertension and if detected early enough, may be reversed with novel therapeutic approaches. In this proposal, we will perform experiments that will validate our hypothesis in several forms of hypertension in previously well established animal models and then extend them to human kidneys. Animal models will allow for direct comparison of BOLD MRI measurements against invasive laser probe assessments. Our human studies are designed to test the hypothesis that subjects at risk for developing hypertension will exhibit reduced renal microvascular reactivity. Successful outcome will provide better understanding of pathophysiology of human hypertension.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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POTTUMARTHI V PRASAD其他文献
POTTUMARTHI V PRASAD的其他文献
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{{ truncateString('POTTUMARTHI V PRASAD', 18)}}的其他基金
In vivo Fractional Blood Volume: Contributions to Renal BOLD MRI.
体内血容量分数:对肾脏 BOLD MRI 的贡献。
- 批准号:
10395426 - 财政年份:2021
- 资助金额:
$ 42.02万 - 项目类别:
Intrarenal Oxygenation: An Early Marker for Risk of Developing AKI
肾内氧合:发生 AKI 风险的早期标志
- 批准号:
9263691 - 财政年份:2016
- 资助金额:
$ 42.02万 - 项目类别:
Longitudinal changes in the intra-renal oxygenation by BOLD MRI in patients with
BOLD MRI 对患有以下疾病的患者肾内氧合的纵向变化
- 批准号:
8726380 - 财政年份:2012
- 资助金额:
$ 42.02万 - 项目类别:
Longitudinal changes in the intra-renal oxygenation by BOLD MRI in patients with
BOLD MRI 对患有以下疾病的患者肾内氧合的纵向变化
- 批准号:
8371311 - 财政年份:2012
- 资助金额:
$ 42.02万 - 项目类别:
Longitudinal changes in the intra-renal oxygenation by BOLD MRI in patients with
BOLD MRI 对患有以下疾病的患者肾内氧合的纵向变化
- 批准号:
8507728 - 财政年份:2012
- 资助金额:
$ 42.02万 - 项目类别:
The Intra-renal Oxygenation in CKD as evaluated by BOLD MRI
BOLD MRI 评估 CKD 肾内氧合
- 批准号:
7936137 - 财政年份:2009
- 资助金额:
$ 42.02万 - 项目类别:
The Intra-renal Oxygenation in CKD as evaluated by BOLD MRI
BOLD MRI 评估 CKD 肾内氧合
- 批准号:
7588686 - 财政年份:2009
- 资助金额:
$ 42.02万 - 项目类别:
Intra-renal Bold MRI: Application to Diabetic Nephropathy
肾内 Bold MRI:在糖尿病肾病中的应用
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7455313 - 财政年份:2007
- 资助金额:
$ 42.02万 - 项目类别:
Intra-renal Bold MRI: Application to Diabetic Nephropathy
肾内 Bold MRI:在糖尿病肾病中的应用
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7651400 - 财政年份:2007
- 资助金额:
$ 42.02万 - 项目类别:
Intra-renal Bold MRI: Application to Diabetic Nephropathy
肾内 Bold MRI:在糖尿病肾病中的应用
- 批准号:
7261638 - 财政年份:2007
- 资助金额:
$ 42.02万 - 项目类别:
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$ 42.02万 - 项目类别:
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BOLD MRI: Application to Intrarenal Oxygenation
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BOLD MRI: Application to Intra-renal Oxygenation
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