Structure and Function of Paxillin

Paxillin 的结构和功能

基本信息

  • 批准号:
    10396034
  • 负责人:
  • 金额:
    $ 40.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-01 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The broad ongoing objective of this research program is to gain a deeper understanding of the fundamental mechanisms by which the focal adhesion adaptor/scaffold proteins paxillin and Hic-5 contribute to cell-matrix signaling and thereby control of cell polarity and migration in development and disease. Importantly, communication between the three elements of the cytoskeleton, the trafficking machinery and cell-matrix interactions is essential for establishing both apical-basal and front-rear migration polarity. However, our understanding of the key mechanisms coordinating and integrating these processes remains incomplete. Through our development of new paxillin and Hic-5 knock out mouse models, in combination with the use of various ex-vivo 1D, 2D and 3D cell matrix and organoid model systems and real time imaging approaches, we have identified new roles for paxillin in establishing epithelial and mesenchymal cell polarity, including regulation of centrosome and Golgi organization and microtubule stability via control of HDAC6 activity. We have also identified Hic-5 as a new mediator of F-actin-intermediate filament cross talk, mechanobiology and 3D extracellular matrix deposition and remodeling. Using these model systems in conjunction with quantitative real time confocal, light sheet and super resolution imaging approaches, the main goals that we will address in the upcoming funding period are- Goal 1: How does paxillin contribute to the regulation of polarized trafficking in directed mesenchymal cell migration? Goal 2: What is the role of paxillin in establishment of apical-basal polarity and in branching morphogenesis in mammary epithelial cells and Goal 3: How does Hic-5 regulate the vimentin intermediate filament cytoskeleton organization and function in motile cells and during epithelial-mesenchymal transition? Through the elucidation of these mechanisms we will be better positioned to develop rational approaches to disease intervention and to appreciate the basis of developmental disorders.
项目总结

项目成果

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Christopher E Turner其他文献

Christopher E Turner的其他文献

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{{ truncateString('Christopher E Turner', 18)}}的其他基金

Structure and Function of Paxillin
Paxillin 的结构和功能
  • 批准号:
    10611918
  • 财政年份:
    2019
  • 资助金额:
    $ 40.5万
  • 项目类别:
Paxillin and Hic-5 in Coordination of Cancer Cell Invasion Mechanisms
Paxillin 和 Hic-5 协调癌细胞侵袭机制
  • 批准号:
    8216208
  • 财政年份:
    2012
  • 资助金额:
    $ 40.5万
  • 项目类别:
Paxillin and Hic-5 in Coordination of Cancer Cell Invasion Mechanisms
Paxillin 和 Hic-5 协调癌细胞侵袭机制
  • 批准号:
    8627588
  • 财政年份:
    2012
  • 资助金额:
    $ 40.5万
  • 项目类别:
Paxillin and Hic-5 in Coordination of Cancer Cell Invasion Mechanisms
Paxillin 和 Hic-5 协调癌细胞侵袭机制
  • 批准号:
    8462943
  • 财政年份:
    2012
  • 资助金额:
    $ 40.5万
  • 项目类别:
Paxillin and Hic-5 in Coordination of Cancer Cell Invasion Mechanisms
Paxillin 和 Hic-5 协调癌细胞侵袭机制
  • 批准号:
    8828598
  • 财政年份:
    2012
  • 资助金额:
    $ 40.5万
  • 项目类别:
Structure and Function of Paxillin
Paxillin 的结构和功能
  • 批准号:
    7933357
  • 财政年份:
    2009
  • 资助金额:
    $ 40.5万
  • 项目类别:
ILK-Actopaxin Interactions in Cell Signaling
ILK-Actopaxin 在细胞信号转导中的相互作用
  • 批准号:
    7192947
  • 财政年份:
    2007
  • 资助金额:
    $ 40.5万
  • 项目类别:
ILK-Actopaxin Interactions in Cell Signaling
ILK-Actopaxin 在细胞信号转导中的相互作用
  • 批准号:
    7568280
  • 财政年份:
    2007
  • 资助金额:
    $ 40.5万
  • 项目类别:
ILK-Actopaxin Interactions in Cell Signaling
ILK-Actopaxin 在细胞信号转导中的相互作用
  • 批准号:
    7356055
  • 财政年份:
    2007
  • 资助金额:
    $ 40.5万
  • 项目类别:
ILK-Actopaxin Interactions in Cell Signaling
ILK-Actopaxin 在细胞信号转导中的相互作用
  • 批准号:
    7760145
  • 财政年份:
    2007
  • 资助金额:
    $ 40.5万
  • 项目类别:
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