Decoding the enigmatic biology of human gamma-delta T cells

解读人类 γ-δ T 细胞的神秘生物学

• 批准号: DE210100705
• 负责人: Dr Nicholas Gherardin
• 金额: $ 32.56万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE210100705
• 关键词: Decoding; enigmatic; biology; human; gamma

The immune system surveys our body examining molecules that signal whether or not everything is ok. T cells are a central to this and use their receptors to monitor these molecular signals. A specialised subset of T cells known as gamma-delta T cells are critical to detecting infection and cancer, yet their fundamental biology is poorly understood. This project aims to unravel this elusive biology. The aims are to understand 1. The diversity in function between gamma-delta T cell subsets, and 2. The diversity in gamma-delta T cell receptors and the molecules that these receptors detect. This work is essential for understanding gamma-delta T cell immunology which is critical if we ultimately wish to harness this to improve human health.

免疫系统检查我们的身体，检查分子信号是否一切正常。T细胞是其中的核心，并使用它们的受体来监测这些分子信号。一种被称为γ-δ T细胞的特殊T细胞亚群对于检测感染和癌症至关重要，但人们对它们的基本生物学知之甚少。这个项目旨在揭开这种难以捉摸的生物学。目的是了解1。γ-δ T细胞亚群之间功能的多样性，以及2.γ-δ T细胞受体和这些受体检测的分子的多样性。这项工作对于理解γ-δ T细胞免疫学至关重要，如果我们最终希望利用它来改善人类健康，这一点至关重要。