Biosynthetic Hooks for an Enigmatic Marine Toxin

用于神秘海洋毒素的生物合成钩子

• 批准号: DP230100495
• 负责人: Prof Brett Neilan
• 金额: $ 44.4万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100495
• 关键词: Biosynthetic; Hooks; Enigmatic; Marine; Toxin

This project aims to characterise the genetic basis for the production of tetrodotoxin; a potent neurotoxin of ecological and biomedical significance. We hypothesise that tetrodotoxin is produced by microorganisms and transferred via the food web to fish, molluscs and other marine animals. Our integrated genomic and synthetic biology approach, targeting key biosynthesis genes, will reveal pathways for the production of tetrodotoxin and other potentially valuable compounds. In addition to providing unprecedented insight into the ecology and biosynthesis of this enigmatic toxin, the data generated will enable improved management of seafood safety and provide a foundation for the future development of novel neuroactive compounds.

该项目旨在研究河豚毒素产生的遗传基础;河豚毒素是一种具有生态和生物医学意义的强效神经毒素。我们假设河豚毒素是由微生物产生的，并通过食物网转移到鱼类，软体动物和其他海洋动物。我们的综合基因组和合成生物学方法，针对关键的生物合成基因，将揭示河豚毒素和其他潜在的有价值的化合物的生产途径。除了对这种神秘毒素的生态学和生物合成提供前所未有的见解外，所产生的数据还将有助于改善海产品安全管理，并为未来开发新型神经活性化合物提供基础。