REACH Participant Diversity Program

REACH 参与者多元化计划

• 批准号: 10399813
• 负责人: Yulin Hswen
• 金额: $ 60.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-25 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10399813
• 关键词: Address; Advocacy; Advocate; Algorithms; Area; Asians; Back Pain; Biological; Blood; California; Caring; Chronic low back pain; Clinic; Clinical Research; Clinical Sciences; Communities; Cultural Backgrounds; Data; Data Element; Doctor of Medicine; Doctor of Philosophy; Enrollment; Ensure; Fostering; Funding; Goals; Helping to End Addiction Long-term; Institutes; Latinx; Lead; Light; Location; Longitudinal cohort study; Magnetic Resonance Imaging; Measures; Methods; Minority; Minority Groups; Minority Participation; Orthopedic Surgery; Outcome; Pain; Pain Research; Pain management; Participant; Patient Recruitments; Patients; Persons; Phenotype; Physical Function; Plant Roots; Population; Protocols documentation; Randomized Controlled Trials; Research; Research Personnel; San Francisco; Schedule; Sensory; Sequential Multiple Assignment Randomized Trial; Site; Surveys; Testing; Training; Translational Research; Underserved Population; United States; Universities; Vertebral column; Visit; base; community engagement; cultural competence; design; digital; diversity and inclusion; improved; individual patient; marginalized population; minority communities; outreach; patient engagement; patient oriented; personalized medicine; precision medicine; programs; psychologic; recruit; response; retention rate; social; targeted treatment; trial design

Project Summary The UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain (REACH) is a U-19 Back Pain Consortium (BACPAC) Mechanistic Research Center (MRC), funded by the Helping to End Addiction Long-term (HEAL) initiative. As an MRC, REACH is focused on discovery of chronic low back pain (cLBP) mechanisms, generating data for deep phenotyping, and developing algorithms that allow targeting of therapies to individual patients. REACH is led by Jeffrey Lotz, PhD, the David S. Bradford M.D. Endowed Chair in Orthopaedic Surgery at UCSF, and Vice Chair of Research within the Department, and Conor O'Neill, MD, Director of the Department's Non-Operative Spine Program. Other REACH investigators include collaborators at UC Davis, UC Irvine, and UC San Diego. The UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain (REACH) is a U- 19 Back Pain Consortium (BACPAC) Mechanistic Research Center (MRC), funded by HEAL. As an MRC, REACH is focused on discovery of cLBP mechanisms and phenotypes, which will ultimately lead to precision medicine for cLBP. REACH is conducting two longitudinal cohort studies, comeBack and BackHome. In both studies, data elements from psychological, biological, and social domains are measured. BackHome is a site-less, digital study that does not require an in-person visit. All data is collected from patient surveys (i.e., light phenotyping). In comeBack, light phenotyping is augmented by a number of deep phenotyping measures that require an in-person visit (e.g., MRI, physical function testing, quantitative sensory testing, blood draw). The duration of each study is two years. The target enrollment for comeBack is 400 subjects, and for BackHome 5000 subjects. Enrollment from UCSF will be supplemented by collaborators at three other University of California locations (Davis, Irvine, and San Diego). In addition to comeBACK and BackHome, REACH will be participating in the BACPAC Collaborative Clinical Study (CCS), which is scheduled to start enrolling subjects from a number of sites across the US in February of 2022. The CCS will utilize a sequential, multiple assignment randomized trial (SMART) design to identify phenotypes associated with response to cLBP treatments. It is vital that cLBP study participants reflect the diversity of the United States population. To date, however, minorities have been under-represented in back pain study enrollment. The objective of our proposal is to optimize diversity and inclusion in REACH cLBP studies.

项目摘要 加州大学旧金山分校慢性腰痛（REACH）以患者为中心的机制表型核心中心是一个 U-19背痛联盟（BACPAC）机械研究中心（MRC），由帮助结束 成瘾长期（HEAL）倡议。作为MRC，REACH专注于发现慢性腰痛 （cLBP）机制，生成用于深度表型分析的数据，并开发允许靶向 对个别患者进行治疗。REACH由Jeffrey Lotz博士领导，大卫S。布拉德福德医学博士赋予 加州大学旧金山分校矫形外科主任，系内研究副主任，康纳奥尼尔， 医学博士，该部门的非手术脊柱项目主任。其他REACH研究人员包括 加州大学戴维斯分校，加州大学欧文分校和加州大学圣地亚哥分校的合作者。 加州大学旧金山分校的核心中心为患者为中心的机制表型在慢性腰痛（REACH）是一个U- 19背部疼痛联盟（BACPAC）机械研究中心（MRC），由HEAL资助。作为一名MRC， REACH专注于发现cLBP机制和表型，这将最终导致精确 治疗cLBP REACH正在进行两项纵向队列研究，comeBack和BackHome。在这两项研究中， 从心理，生物，和社会领域进行测量。BackHome是一个无站点的数字研究， 不需要亲自去拜访。所有数据均来自患者调查（即，光表型分析）。在 comeBack，轻表型是由一些深表型的措施，需要在人增强 访问（例如，MRI、身体功能测试、定量感觉测试、抽血）。每项研究的持续时间 是两年comeBack的目标入组人数为400例受试者，BackHome为5000例受试者。招生 来自加州大学旧金山分校的合作者将在其他三个加州大学的位置（戴维斯，欧文， San Diego）。 除了comeBACK和BackHome，REACH还将参加BACPAC协作临床 研究（CCS），该研究计划于2009年2月开始从美国各地的一些研究中心招募受试者。 2022. CCS将采用序贯、多重分配随机试验（SMART）设计，以确定 与对cLBP治疗的反应相关的表型。 至关重要的是，cLBP研究参与者反映了美国人口的多样性。然而，迄今为止， 少数民族在背痛研究登记中的代表性不足。我们建议的目的是 优化REACH cLBP研究的多样性和包容性。