Socioenvironmental Causes of Elevated Toxic Metal Levels and Epigenetic Aging

有毒金属水平升高和表观遗传衰老的社会环境原因

• 批准号: 10400581
• 负责人: Evans Lodge
• 金额: $ 4.22万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400581
• 关键词: Adult; Affect; Age; Aging; American; Americas; Area; Biological; Biological Aging; Biological Markers; Biological Process; Cardiovascular Diseases; Censuses; Characteristics; Chromium; Chronology; Cities; Clinical; Clinical Medicine; Community Surveys; County; DNA Methylation; Data; Development; Disease; Economics; Endocrine System Diseases; Environmental Exposure; Environmental Pollutants; Environmental Pollution; Epidemiologist; Epidemiology; Epigenetic Process; Exposure to; Health; Heavy Metals; Housing; Human; Individual; Industrial Waste; Industrialization; Infrastructure; Joints; Lead; Lead levels; Linear Models; Link; Location; Longitudinal cohort; Malignant Neoplasms; Manganese; Measures; Mercury; Metal exposure; Metals; Michigan; Minority; Morbidity - disease rate; Neighborhoods; Nervous System Trauma; Occupations; Participant; Physicians; Policy Maker; Pollution; Population; Process; Public Health; Race; Research; Risk; Role; Route; Sampling; Scientist; Serum; Site; Social Environment; Socioeconomic Status; Sum; Toxic effect; Training; Transportation; United States; United States Environmental Protection Agency; Water; Work; aged; body system; built environment; cohort; density; environmental change; exposed human population; flexibility; high risk; insight; interest; lead concentration; lead exposure; low socioeconomic status; meetings; metal poisoning; mortality; novel; population health; public health priorities; remediation; reproductive; skills; social; social disadvantage; toxic metal; urban area; urban setting; wasting

Project Summary: Reducing human exposure to toxic metals is a national and global public health priority. The risk of exposure to toxic metals is unevenly distributed across the United States, with a much higher burden of exposure to many industrial pollutants in densely populated urban areas among individuals of lower socioeconomic position and minority race. Although links between individual characteristics (socioeconomic position, occupation, access to clean water, etc.) and biomarkers of elevated toxic metals have been previously established, few studies have investigated the effect of large-scale social, economic, and environmental changes on serum metal levels. Given rapid changes in many American urban areas due to industrial activity and deindustrialization, understanding the population-level risks posed by urban industrial environmental pollution and neighborhood socioenvironmental change is imperative to mitigate the effects of toxic metals on population health. The objectives of this proposal are to (1) characterize the effects of urban socioenvironmental changes on individual and joint serum lead (Pb), mercury (Hg), chromium (Cr), and manganese (Mn), and (2) assess the individual and simultaneous effects of Pb, Hg, Cr, and Mn on epigenetic aging. Longitudinal data from 779 participants in the 2008-2013 Detroit Neighborhood Health Study (DNHS) and data on location-specific urban environmental pollutants from the American Community Survey, Michigan Department of Environmental Quality, and Michigan Department of Transportation will be used to assess the effects of block group building quality, vacant housing, brownfield pollution, and commercial traffic density on longitudinal measures of serum Pb, Hg, Cr, and Mn. Longitudinal measures of epigenetic age generated from DNA methylation analysis will be used to assess the individual and joint effects of Pb, Hg, Cr, and Mn on accelerated biological aging. The completion of the proposed aims will significantly advance our understanding of the burden of metal exposures in urban America, as well as their individual and joint effects on epigenetic aging, an accurate predictor of all-cause mortality. The DNHS provides an excellent opportunity to conduct the proposed research using longitudinal data from a representative sample of adults in a heavily industrialized city undergoing significant redevelopment. The training plan outlined in this F30 proposal will equip the applicant with the necessary skills in social, environmental, and epigenetic epidemiology and clinical medicine to successfully complete the proposed aims and progress into a role as a physician-scientist studying the interrelated effects of social disadvantage and environmental pollution on population health in the United States. The applicant is extremely well supported by an interdisciplinary group of epidemiologists, toxicologists, environmental scientists, geographers, and clinicians with the requisite expertise to support his clinical training and doctoral research.

项目概要： 减少人类接触有毒金属是国家和全球公共卫生的优先事项。暴露风险 有毒金属在美国各地分布不均匀，许多人接触有毒金属的负担要高得多。 在人口稠密的城市地区，社会经济地位较低的个人中的工业污染物， 少数民族。虽然个人特征（社会经济地位、职业、获得 清洁水等）和生物标志物的升高有毒金属已经建立，很少有研究 研究了大规模社会、经济和环境变化对血清金属水平的影响。给定 由于工业活动和去工业化，许多美国城市地区发生了快速变化， 城市工业环境污染和邻里社会环境污染对人口水平的风险 必须进行变革，以减轻有毒金属对人口健康的影响。 本提案的目标是：（1）描述城市社会环境变化对 个体和联合血清铅（Pb）、汞（Hg）、铬（Cr）和锰（Mn），以及（2）评估 铅、汞、铬和锰对表观遗传衰老的单独和同时影响。779的纵向数据 2008-2013年底特律社区健康研究（DNHS）的参与者和特定位置的城市数据 环境污染物来自美国社区调查，密歇根州环境质量部， 和密歇根州交通部将被用来评估块组建筑质量的影响， 空置住房、布朗菲尔德污染和商业交通密度对血清铅、汞、 Cr和Mn。DNA甲基化分析产生的表观遗传年龄的纵向测量将用于 评估铅、汞、铬和锰对加速生物老化的单独和联合影响。完成 提出的目标将大大促进我们对城市金属暴露负担的理解， 美国，以及它们对表观遗传衰老的个体和联合影响， mortality. DNHS提供了一个极好的机会，利用纵向数据进行拟议的研究 从一个正在经历重大重建的重工业化城市的成年人代表性样本中。 本F30提案中概述的培训计划将使申请人具备必要的社交技能， 环境、表观遗传流行病学和临床医学，以成功地完成拟议的目标 并逐渐成为一名研究社会劣势的相互影响的物理学家， 环境污染对美国人口健康的影响。申请人得到了很好的支持 由流行病学家、毒理学家、环境科学家、地理学家和 临床医生与必要的专业知识，以支持他的临床培训和博士研究。