Chem Science Facility Core

化学科学设施核心

• 批准号: 10400884
• 负责人: ARUL JAYARAMAN
• 金额: $ 16.92万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400884
• 关键词: Biological; Biological Markers; Biological Models; Cells; Chemical Exposure; Chemicals; Complex Mixtures; Consultations; Core Facility; Data Science; Detection; Doctor of Philosophy; Dose; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Pollution; Equipment; Experimental Models; Exposure to; Foundations; Gas-Liquid Chromatography; Genomics; Goals; Immune response; Infrastructure; Institutes; Interdisciplinary Study; Laboratories; Mass Fragmentography; Mass Spectrum Analysis; Measurement; Measures; Methodology; Methods; Molecular; Molecular Analysis; Positioning Attribute; Public Health; Research; Research Personnel; Resources; Risk; Sampling; Science; Services; Specialist; System; Target Populations; Technology; Texas; Tissues; Toxic Environmental Substances; Toxicology; Translational Research; base; data management; epigenome; experience; genome analysis; genome sciences; geochemistry; instrument; instrumentation; liquid chromatography mass spectrometry; metabolomics; microbiome; microbiome components; microbiota; novel; novel marker; predictive modeling; research study; response; science and society; small molecule; tool; transcriptome; transcriptomics

Chem Science Facility Core ABSTRACT The proposed Texas A&M Center for Environmental Health Research (TiCER) is focused on “Enhancing Public Health by Identifying, Understanding and Reducing Adverse Environmental Health Risks.” Towards this goal, the Chem Science Facility Core (CSFC) will provide Center investigators access to state-of-the-art analytical and characterization tools for quantifying various exposure agents in the environment as well as measuring biological markers of the effects of exposure from experimental model systems. The ability to measure the levels of specific agents in the environment and detect biomarkers or signatures of downstream biological effects in experimental models will enable Center investigators to develop dose-response studies for specific agents, model the biological response as a result of exposure, and/or accurately predict the potential risk of target populations to specific exposures. The CSFC will comprise three complementary components that together will provide Center investigators with a continuum of analytical capabilities for comprehensively characterizing the response to environmental exposures and contaminants. The chemical exposure science component will provide state-of-the-art facilities for detection and quantitative analysis of potential environmental toxicants in complex mixtures using gas and liquid chromatography-based mass spectrometry systems (GC/MS/MS and LC/MS/MS). The genomics and microbiome component will provide molecular technologies required for characterizing changes in genomic and transcriptomic signatures in tissues, single cells, and the microbiota arising from environmental exposures. The metabolomics component will provide resources for characterizing small molecule responses to environmental contaminants using LC/MS/MS and GC/MS/MS platforms for both discovery and quantitation of biomarkers. While these foundational components already exist as multi-user core facilities at Texas A&M, the CSFC is a new entity that will provide a mechanism for integrating the diverse readouts and measurements across scales and with assistance of a data management specialist from the Data Science Facility Core. Thus, the CSFC will not only leverage existing infrastructure at Texas A&M but also provide novel capabilities and services to Center investigators under a single unified umbrella that would otherwise be difficult to access. Integrating under a single thematic umbrella will also ensure that Center investigators have access to the expertise and resources to investigate multiple facets of the response to environmental contaminants across the exposure-response spectrum in a coordinated manner. !

化学科学设施核心摘要 拟议中的德克萨斯农工环境健康研究中心(TICER)致力于“增强 通过识别、了解和减少不利的环境健康风险来促进公共健康。朝向这个方向 Goal，化学科学设施核心(CSFC)将为中心的研究人员提供访问最先进的 用于量化环境中各种曝光剂的分析和表征工具以及 从实验模型系统测量暴露影响的生物标记物。测量的能力 环境中特定制剂的水平并检测下游生物的生物标志物或特征 实验模型中的效应将使中心研究人员能够开发针对特定疾病的剂量-反应研究 作为暴露结果的生物反应的模拟，和/或准确地预测 针对特定暴露的目标人群。CSFC将由三个相辅相成的组成部分组成 共同为中心调查人员提供一系列全面的分析能力 描述对环境暴露和污染物的反应。化学曝露科学 该组件将提供最先进的设施，用于检测和定量分析潜在的环境 用气相色谱和液质联用系统测定复杂混合物中的毒物 (GC/MS/MS和LC/MS/MS)。基因组学和微生物组部分将提供分子技术 描述组织、单细胞和组织中基因组和转录特征变化所必需的 环境暴露产生的微生物区系。代谢组学部分将为 LC/MS/MS和GC/MS/MS表征小分子对环境污染物的响应 生物标志物发现和量化的平台。虽然这些基本组件已经存在 作为德克萨斯A&M的多用户核心设施，CSFC是一个新的实体，将提供一种机制来整合 在数据管理专家的协助下，不同规模的读数和测量结果 来自数据科学设施核心。因此，CSFC不仅将利用德克萨斯A&M的现有基础设施 还可以在一个统一的保护伞下为中心调查人员提供新的能力和服务 否则很难访问。在单一主题下整合也将确保该中心 调查人员可以获得专业知识和资源，以调查反应的多个方面 以协调的方式处理暴露-反应谱中的环境污染物。 好了！